{"id":"https://openalex.org/W2117548735","doi":"https://doi.org/10.1142/s0219878907001289","title":"A NOVEL INTEGRATED CELL-BASED BIOSENSOR FOR EXTRACELLULAR ELECTROPHYSIOLOGICAL MONITORING","display_name":"A NOVEL INTEGRATED CELL-BASED BIOSENSOR FOR EXTRACELLULAR ELECTROPHYSIOLOGICAL MONITORING","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W2117548735","doi":"https://doi.org/10.1142/s0219878907001289","mag":"2117548735"},"language":"en","primary_location":{"id":"doi:10.1142/s0219878907001289","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219878907001289","pdf_url":null,"source":{"id":"https://openalex.org/S186208447","display_name":"International Journal of Information Acquisition","issn_l":"0219-8789","issn":["0219-8789","1793-6985"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Information Acquisition","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074976551","display_name":"Ying Xu","orcid":"https://orcid.org/0000-0002-9987-2057"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"YING XU","raw_affiliation_strings":["Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China","Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"],"affiliations":[{"raw_affiliation_string":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108058531","display_name":"Hui Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210107198","display_name":"State Key Laboratory of Transducer Technology","ror":"https://ror.org/01qg56n75","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366","https://openalex.org/I19820366","https://openalex.org/I4210107198","https://openalex.org/I4210110458","https://openalex.org/I4210147322"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HUI YU","raw_affiliation_strings":["State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China","institution_ids":["https://openalex.org/I4210107198","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113748736","display_name":"Hua Cai","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210107198","display_name":"State Key Laboratory of Transducer Technology","ror":"https://ror.org/01qg56n75","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366","https://openalex.org/I19820366","https://openalex.org/I4210107198","https://openalex.org/I4210110458","https://openalex.org/I4210147322"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HUA CAI","raw_affiliation_strings":["State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China","institution_ids":["https://openalex.org/I4210107198","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100682219","display_name":"Qingjun Liu","orcid":"https://orcid.org/0000-0002-9442-9355"},"institutions":[{"id":"https://openalex.org/I4210107198","display_name":"State Key Laboratory of Transducer Technology","ror":"https://ror.org/01qg56n75","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366","https://openalex.org/I19820366","https://openalex.org/I4210107198","https://openalex.org/I4210110458","https://openalex.org/I4210147322"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"QINGJUN LIU","raw_affiliation_strings":["State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China","institution_ids":["https://openalex.org/I4210107198","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100338600","display_name":"Ping Wang","orcid":"https://orcid.org/0000-0001-6474-2722"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210107198","display_name":"State Key Laboratory of Transducer Technology","ror":"https://ror.org/01qg56n75","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366","https://openalex.org/I19820366","https://openalex.org/I4210107198","https://openalex.org/I4210110458","https://openalex.org/I4210147322"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"PING WANG","raw_affiliation_strings":["Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China","State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China"],"affiliations":[{"raw_affiliation_string":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China","institution_ids":["https://openalex.org/I4210107198","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5074976551"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17160629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"04","issue":"03","first_page":"193","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7108935713768005},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.6903491020202637},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.6431200504302979},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.5040689706802368},{"id":"https://openalex.org/keywords/microelectronics","display_name":"Microelectronics","score":0.5020339488983154},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.46803122758865356},{"id":"https://openalex.org/keywords/potentiometric-sensor","display_name":"Potentiometric sensor","score":0.45471736788749695},{"id":"https://openalex.org/keywords/multielectrode-array","display_name":"Multielectrode array","score":0.432117223739624},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.42020106315612793},{"id":"https://openalex.org/keywords/computer-hardware","display_name":"Computer hardware","score":0.36577123403549194},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.35914790630340576},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.3495338261127472},{"id":"https://openalex.org/keywords/potentiometric-titration","display_name":"Potentiometric titration","score":0.29754090309143066},{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.28139054775238037},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.25746360421180725},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22742310166358948},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.22401666641235352},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.1916520595550537},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11909288167953491},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.09197261929512024}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7108935713768005},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6903491020202637},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6431200504302979},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.5040689706802368},{"id":"https://openalex.org/C187937830","wikidata":"https://www.wikidata.org/wiki/Q175403","display_name":"Microelectronics","level":2,"score":0.5020339488983154},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.46803122758865356},{"id":"https://openalex.org/C195767000","wikidata":"https://www.wikidata.org/wiki/Q17105334","display_name":"Potentiometric sensor","level":4,"score":0.45471736788749695},{"id":"https://openalex.org/C95967509","wikidata":"https://www.wikidata.org/wiki/Q1952355","display_name":"Multielectrode array","level":4,"score":0.432117223739624},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.42020106315612793},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.36577123403549194},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.35914790630340576},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.3495338261127472},{"id":"https://openalex.org/C124614425","wikidata":"https://www.wikidata.org/wiki/Q1813495","display_name":"Potentiometric titration","level":3,"score":0.29754090309143066},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.28139054775238037},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25746360421180725},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22742310166358948},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22401666641235352},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.1916520595550537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11909288167953491},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09197261929512024},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0219878907001289","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219878907001289","pdf_url":null,"source":{"id":"https://openalex.org/S186208447","display_name":"International Journal of Information Acquisition","issn_l":"0219-8789","issn":["0219-8789","1793-6985"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Information Acquisition","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1977486054","https://openalex.org/W1978267171","https://openalex.org/W1985388083","https://openalex.org/W2034179902","https://openalex.org/W2036213823","https://openalex.org/W2072005918","https://openalex.org/W2073812166","https://openalex.org/W2087608775","https://openalex.org/W2089289309","https://openalex.org/W2110248176","https://openalex.org/W2162263062"],"related_works":["https://openalex.org/W1981400123","https://openalex.org/W3016525403","https://openalex.org/W2046430340","https://openalex.org/W2322026400","https://openalex.org/W2383021773","https://openalex.org/W1520169471","https://openalex.org/W4206515393","https://openalex.org/W1990396141","https://openalex.org/W3206835165","https://openalex.org/W2089998377"],"abstract_inverted_index":{"A":[0],"rigorous":[1],"preselection":[2],"of":[3,42,79,106,119,138,147],"identified":[4],"compounds":[5],"by":[6,45,129],"in":[7,156],"vitro":[8],"cellular":[9],"screening":[10],"is":[11],"necessary":[12],"prior":[13],"to":[14,65],"using":[15,46],"the":[16,20,67,82,100,104,139,145,148],"drug":[17],"candidates":[18],"for":[19,167],"further":[21],"time":[22],"consuming":[23],"and":[24,59,71,76,115,133,150,165],"parallel":[25,168],"monitoring":[26],"stage.":[27],"In":[28,85],"this":[29,86],"paper":[30],"we":[31,88,142],"introduced":[32],"an":[33,93],"integrated":[34],"cell":[35,96,107],"based":[36],"chip":[37],"which":[38],"can":[39],"detect":[40],"changes":[41],"electrophysiological":[43,117],"parameters":[44],"microelectronic":[47],"chips":[48],"such":[49],"as":[50,103],"Light-Addressable":[51],"Potentiometric":[52],"Sensors":[53,57],"(LAPS),":[54],"Micro-electrodes":[55],"Array":[56,61],"(MEAS)":[58],"Interdigitated":[60],"Sensor":[62],"(IDA)":[63],"etc.":[64],"record":[66],"extracellular":[68,169],"metabolism":[69],"chemical":[70],"biological":[72],"substances,":[73],"action":[74],"potential":[75],"living":[77,101,131],"characteristics":[78],"cells":[80,102,135],"representing":[81],"different":[83,157],"response.":[84],"research":[87,161],"presented":[89],"novel":[90],"ideas":[91],"including":[92],"integrating":[94],"multifunctional":[95],"sensors":[97,108],"chip,":[98],"obtaining":[99],"source":[105],"with":[109],"cardiac":[110],"myocytes.":[111],"The":[112],"characteristic":[113],"curve":[114],"primary":[116],"measurement":[118],"each":[120],"part":[121],"were":[122],"tested.":[123],"Further":[124],"developments":[125],"will":[126,162],"be":[127,163],"done":[128],"culturing":[130],"olfactory":[132],"taste":[134],"on":[136],"surface":[137],"devices.":[140],"Now,":[141],"have":[143],"completed":[144],"fabrication":[146],"sensor":[149,158],"obtained":[151],"some":[152],"promising":[153],"experiments":[154],"results":[155],"units.":[159],"This":[160],"interesting":[164],"useful":[166],"monitoring.":[170]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}