{"id":"https://openalex.org/W4414563140","doi":"https://doi.org/10.1142/s0219720025500179","title":"Simulating therapeutic combinations for lung cancer patients with heterogeneous genetic predisposition","display_name":"Simulating therapeutic combinations for lung cancer patients with heterogeneous genetic predisposition","publication_year":2025,"publication_date":"2025-09-26","ids":{"openalex":"https://openalex.org/W4414563140","doi":"https://doi.org/10.1142/s0219720025500179","pmid":"https://pubmed.ncbi.nlm.nih.gov/41083418"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720025500179","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720025500179","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100394373","display_name":"L. Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I4210158570","display_name":"Zhejiang University-University of Edinburgh Institute","ror":"https://ror.org/04jth1r26","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210158570","https://openalex.org/I76130692","https://openalex.org/I98677209"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanqi Wu","raw_affiliation_strings":["Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I4210158570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089092437","display_name":"Ruocheng Yu","orcid":"https://orcid.org/0000-0001-7268-7508"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I4210158570","display_name":"Zhejiang University-University of Edinburgh Institute","ror":"https://ror.org/04jth1r26","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210158570","https://openalex.org/I76130692","https://openalex.org/I98677209"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruocheng Yu","raw_affiliation_strings":["Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I4210158570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060390742","display_name":"Minghui Yao","orcid":"https://orcid.org/0000-0002-6313-268X"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I4210158570","display_name":"Zhejiang University-University of Edinburgh Institute","ror":"https://ror.org/04jth1r26","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210158570","https://openalex.org/I76130692","https://openalex.org/I98677209"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghui Yao","raw_affiliation_strings":["Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I4210158570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012688730","display_name":"Md. Matiur Rahaman","orcid":"https://orcid.org/0000-0001-9799-9364"},"institutions":[{"id":"https://openalex.org/I132877587","display_name":"Gopalganj Science and Technology University","ror":"https://ror.org/011xjpe74","country_code":"BD","type":"education","lineage":["https://openalex.org/I132877587"]},{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I4210158570","display_name":"Zhejiang University-University of Edinburgh Institute","ror":"https://ror.org/04jth1r26","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210158570","https://openalex.org/I76130692","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["BD","CN","GB"],"is_corresponding":false,"raw_author_name":"Md. Matiur Rahaman","raw_affiliation_strings":["Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China","Department of Statistics, Faculty of Science, Gopalganj Science and Technology University, Gopalganj 8105, Bangladesh","Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I4210158570"]},{"raw_affiliation_string":"Department of Statistics, Faculty of Science, Gopalganj Science and Technology University, Gopalganj 8105, Bangladesh","institution_ids":["https://openalex.org/I132877587"]},{"raw_affiliation_string":"Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005485315","display_name":"Zhaoyuan Fang","orcid":"https://orcid.org/0000-0002-0393-2052"},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210101214","display_name":"Zhejiang Yongning Pharma (China)","ror":"https://ror.org/017qmh907","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210101214"]},{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I4210158570","display_name":"Zhejiang University-University of Edinburgh Institute","ror":"https://ror.org/04jth1r26","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210158570","https://openalex.org/I76130692","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Zhaoyuan Fang","raw_affiliation_strings":["Biomedical and Health Translational Research, Center of Zhejiang Province, Haining 314400, P.\u00a0R.\u00a0China","Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China","Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, United Kingdom","Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Hangzhou 310003, P.\u00a0R.\u00a0China"],"raw_orcid":"https://orcid.org/0000-0002-0393-2052","affiliations":[{"raw_affiliation_string":"Biomedical and Health Translational Research, Center of Zhejiang Province, Haining 314400, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I4210101214"]},{"raw_affiliation_string":"Department of Colorectal Surgery and Oncology of the Second Affiliated Hospital and Centre of Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I4210158570"]},{"raw_affiliation_string":"Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Hangzhou 310003, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I1327237609"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20529481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"5","first_page":"2550017","last_page":"2550017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5687000155448914},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.567300021648407},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.42829999327659607},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.41769999265670776},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"Pembrolizumab","score":0.34549999237060547},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3296999931335449},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.3237000107765198},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.32030001282691956}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5687000155448914},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.567300021648407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.489300012588501},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42829999327659607},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4099000096321106},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3944999873638153},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.34549999237060547},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3409000039100647},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3237000107765198},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.32030001282691956},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2994999885559082},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29440000653266907},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C182707283","wikidata":"https://www.wikidata.org/wiki/Q7315622","display_name":"Resistance mutation","level":5,"score":0.26420000195503235},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C149172746","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Efficacy","level":3,"score":0.25440001487731934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25429999828338623},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.2535000145435333}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720025500179","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720025500179","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:41083418","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41083418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Non-small":[0],"cell":[1],"lung":[2,14],"carcinoma":[3],"(NSCLC)":[4],"is":[5,63,136],"well-known":[6],"for":[7,56,85,132,191],"its":[8],"high":[9],"incidence":[10],"(about":[11],"80%":[12],"of":[13,127,182],"cancer)":[15],"and":[16,25,49,73,92,103,113,130,144,187],"genetic":[17],"heterogeneity.":[18],"Personalized":[19],"driver":[20],"mutations":[21],"such":[22,44],"as":[23,45],"EGFR":[24],"KRAS":[26,128],"have":[27,39],"established":[28],"targeted":[29],"therapies":[30],"with":[31,88,140],"kinase":[32,100],"inhibitors,":[33],"whereas":[34],"immune":[35],"checkpoint":[36],"inhibitors":[37,102],"(ICIs)":[38],"revolutionized":[40],"immunotherapy.":[41],"However,":[42],"challenges":[43],"frequent":[46],"drug":[47],"resistance":[48],"low":[50],"response":[51],"rates":[52],"highlight":[53],"the":[54,94,109,120,145,160,168,175,180],"need":[55],"novel":[57],"therapeutic":[58,95,122,189],"strategies.":[59,77],"Boolean":[60,82,110],"network":[61,83,111],"modeling":[62,184],"a":[64,81,125],"powerful":[65],"mathematical":[66],"tool":[67],"to":[68,155,185],"simulate":[69],"complex":[70],"biological":[71],"processes":[72],"optimize":[74],"potential":[75],"treatment":[76],"This":[78],"study":[79],"developed":[80],"model":[84,112,116,142],"NSCLC":[86],"patients":[87],"different":[89],"mutational":[90],"backgrounds":[91],"evaluated":[93],"effects":[96],"by":[97],"incorporating":[98],"key":[99],"mutation":[101],"immunological":[104],"interventions.":[105],"Simulations":[106],"in":[107,138,174],"both":[108],"another":[114],"quantitative":[115],"consistently":[117],"suggested":[118],"that":[119],"optimal":[121],"strategy":[123],"involves":[124],"combination":[126],"inhibitor":[129],"ICI":[131],"KRAS-mutant":[133],"patients,":[134],"which":[135],"also":[137],"line":[139],"mouse":[141],"studies":[143],"KRYSTAL-7":[146,163],"phase-2":[147],"clinical":[148,165],"trial":[149,166],"data.":[150],"It":[151],"would":[152],"be":[153],"reasonable":[154],"expect":[156],"further":[157],"validations":[158],"from":[159],"recently":[161],"announced":[162],"phase-3":[164],"comparing":[167],"combined":[169],"therapy":[170],"over":[171],"pembrolizumab":[172],"monotherapy":[173],"future.":[176],"Our":[177],"approach":[178],"highlights":[179],"value":[181],"computational":[183],"evaluate":[186],"refine":[188],"strategies":[190],"precision":[192],"oncology.":[193]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-09-27T00:00:00"}
