{"id":"https://openalex.org/W4412056430","doi":"https://doi.org/10.1142/s0219720025500088","title":"Parameter estimation analysis of the glioblastoma immune model","display_name":"Parameter estimation analysis of the glioblastoma immune model","publication_year":2025,"publication_date":"2025-07-04","ids":{"openalex":"https://openalex.org/W4412056430","doi":"https://doi.org/10.1142/s0219720025500088","pmid":"https://pubmed.ncbi.nlm.nih.gov/40808603"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720025500088","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720025500088","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088841696","display_name":"Biao Liu","orcid":"https://orcid.org/0000-0002-7499-6475"},"institutions":[{"id":"https://openalex.org/I118987531","display_name":"Anhui Jianzhu University","ror":"https://ror.org/0108wjw08","country_code":"CN","type":"education","lineage":["https://openalex.org/I118987531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Biao Liu","raw_affiliation_strings":["Operations Research and Data Science Laboratory, Anhui Jianzhu University, P.\u00a0R.\u00a0China","School of Mathematics and Physics, Anhui Jianzhu University, Hefei, Anhui 230601, P.\u00a0R.\u00a0China"],"affiliations":[{"raw_affiliation_string":"Operations Research and Data Science Laboratory, Anhui Jianzhu University, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I118987531"]},{"raw_affiliation_string":"School of Mathematics and Physics, Anhui Jianzhu University, Hefei, Anhui 230601, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I118987531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110687003","display_name":"Meng-Ru Shen","orcid":null},"institutions":[{"id":"https://openalex.org/I118987531","display_name":"Anhui Jianzhu University","ror":"https://ror.org/0108wjw08","country_code":"CN","type":"education","lineage":["https://openalex.org/I118987531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengru Shen","raw_affiliation_strings":["School of Mathematics and Physics, Anhui Jianzhu University, Hefei, Anhui 230601, P.\u00a0R.\u00a0China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Physics, Anhui Jianzhu University, Hefei, Anhui 230601, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I118987531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115594037","display_name":"Ming Zhao","orcid":"https://orcid.org/0009-0000-5361-0361"},"institutions":[{"id":"https://openalex.org/I118987531","display_name":"Anhui Jianzhu University","ror":"https://ror.org/0108wjw08","country_code":"CN","type":"education","lineage":["https://openalex.org/I118987531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiling Zhao","raw_affiliation_strings":["Operations Research and Data Science Laboratory, Anhui Jianzhu University, P.\u00a0R.\u00a0China","School of Mathematics and Physics, Anhui Jianzhu University, Hefei, Anhui 230601, P.\u00a0R.\u00a0China"],"affiliations":[{"raw_affiliation_string":"Operations Research and Data Science Laboratory, Anhui Jianzhu University, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I118987531"]},{"raw_affiliation_string":"School of Mathematics and Physics, Anhui Jianzhu University, Hefei, Anhui 230601, P.\u00a0R.\u00a0China","institution_ids":["https://openalex.org/I118987531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088841696"],"corresponding_institution_ids":["https://openalex.org/I118987531"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23199141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"4","first_page":"2550008","last_page":"2550008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9811999797821045,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9811999797821045,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.8092622756958008},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5539179444313049},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4823879301548004},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4345130920410156},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4240697920322418},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.4121095836162567},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3993508517742157},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.23843157291412354},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.18794625997543335},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11477318406105042}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.8092622756958008},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5539179444313049},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4823879301548004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4345130920410156},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4240697920322418},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.4121095836162567},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3993508517742157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23843157291412354},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.18794625997543335},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11477318406105042},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720025500088","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720025500088","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:40808603","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40808603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1602805286","https://openalex.org/W4225917631","https://openalex.org/W2088686453","https://openalex.org/W4200635075","https://openalex.org/W4400475616","https://openalex.org/W2149738946","https://openalex.org/W2326681941","https://openalex.org/W4361251389","https://openalex.org/W10455127","https://openalex.org/W3161134184"],"abstract_inverted_index":{"In":[0,65,145],"exploring":[1],"optimal":[2],"strategies":[3,190],"for":[4,186,196],"immunotherapy":[5,189],"in":[6],"glioblastoma":[7,35],"(GBM),":[8],"one":[9,26],"of":[10,23,34,46,70,106,115,151,161,176,201],"the":[11,21,32,44,71,98,104,107,113,116,143,147,152,159,172],"main":[12],"challenges":[13],"is":[14],"enhancing":[15],"treatment":[16],"response.":[17],"To":[18],"better":[19],"understand":[20],"dynamics":[22],"tumor-immune":[24],"interactions,":[25],"applied":[27],"Bayesian":[28],"methods":[29],"to":[30,169],"estimate":[31],"parameters":[33],"immune":[36],"model":[37,108,177],"by":[38,74],"using":[39,47,75],"experimental":[40],"data.":[41],"One":[42],"compared":[43],"effects":[45],"uniform":[48],"prior":[49,53,100,164],"distributions":[50,165],"versus":[51],"improved":[52,99],"distributions,":[54],"which":[55,84,141],"were":[56,92,155,179],"adjusted":[57],"based":[58],"on":[59],"posterior":[60,117],"information,":[61],"during":[62],"parameter":[63,109,199],"estimation.":[64],"addition,":[66],"a":[67,137,194],"comparative":[68],"analysis":[69],"results":[72,95],"obtained":[73],"four":[76],"Markov":[77],"Chain":[78],"Monte":[79],"Carlo":[80],"(MCMC)":[81],"sampling":[82,131,167],"algorithms":[83,168],"respectively":[85],"are":[86],"Metropolis,":[87],"DEMetropolis,":[88],"DEMetropolisZ":[89,127],"and":[90,111,123,132,149,166,174,191,198],"NUTS,":[91],"performed.":[93],"The":[94,181],"showed":[96],"that":[97],"distribution":[101],"significantly":[102],"enhanced":[103],"accuracy":[105,173],"estimates,":[110],"reduced":[112],"variance":[114],"distribution,":[118],"but":[119],"increased":[120],"computational":[121],"time":[122,139],"resource":[124],"demands.":[125],"Furthermore,":[126],"provided":[128],"such":[129],"efficient":[130],"narrower":[133],"confidence":[134],"intervals":[135],"within":[136],"shorter":[138],"frame,":[140],"outperformed":[142],"others.":[144],"contrast,":[146],"efficiency":[148,175],"stability":[150],"Metropolis":[153],"method":[154],"relatively":[156],"poor.":[157],"Therefore,":[158],"importance":[160],"selecting":[162],"appropriate":[163],"improve":[170],"both":[171],"inference":[178],"studied.":[180],"study":[182],"provides":[183],"valuable":[184],"insights":[185],"optimizing":[187],"GBM":[188],"serves":[192],"as":[193],"reference":[195],"modeling":[197],"estimation":[200],"complex":[202],"biological":[203],"systems.":[204]},"counts_by_year":[],"updated_date":"2026-02-24T19:35:01.260952","created_date":"2025-10-10T00:00:00"}