{"id":"https://openalex.org/W4402498183","doi":"https://doi.org/10.1142/s0219720024500252","title":"The use of 4D data-independent acquisition-based proteomic analysis and machine learning to reveal potential biomarkers for stress levels","display_name":"The use of 4D data-independent acquisition-based proteomic analysis and machine learning to reveal potential biomarkers for stress levels","publication_year":2024,"publication_date":"2024-09-12","ids":{"openalex":"https://openalex.org/W4402498183","doi":"https://doi.org/10.1142/s0219720024500252","pmid":"https://pubmed.ncbi.nlm.nih.gov/39545813"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720024500252","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720024500252","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114672877","display_name":"Dehua Chen","orcid":"https://orcid.org/0000-0002-1779-8026"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dehua Chen","raw_affiliation_strings":["School of Computer Science and Technology, DongHua University, ShangHai, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, DongHua University, ShangHai, P. R. China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongsheng Yang","orcid":"https://orcid.org/0009-0002-6438-355X"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongsheng Yang","raw_affiliation_strings":["School of Computer Science and Technology, DongHua University, ShangHai, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, DongHua University, ShangHai, P. R. China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101509112","display_name":"Dongdong Shi","orcid":"https://orcid.org/0000-0003-3585-7664"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongdong Shi","raw_affiliation_strings":["ShangHai Mental Health Center, Shanghai JiaoTong University, School of Medicine, P. R. China"],"affiliations":[{"raw_affiliation_string":"ShangHai Mental Health Center, Shanghai JiaoTong University, School of Medicine, P. R. China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhenhua Zhang","orcid":"https://orcid.org/0009-0004-9221-0423"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenhua Zhang","raw_affiliation_strings":["School of Computer Science and Technology, DongHua University, ShangHai, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, DongHua University, ShangHai, P. R. China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mei Wang","orcid":"https://orcid.org/0000-0001-7597-6153"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Wang","raw_affiliation_strings":["School of Computer Science and Technology, DongHua University, ShangHai, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, DongHua University, ShangHai, P. R. China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiao Pan","orcid":"https://orcid.org/0009-0008-5962-2214"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiao Pan","raw_affiliation_strings":["School of Computer Science and Technology, DongHua University, ShangHai, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, DongHua University, ShangHai, P. R. China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069491635","display_name":"Jianwen Su","orcid":"https://orcid.org/0000-0002-4637-1339"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianwen Su","raw_affiliation_strings":["University of California, Santa Barbara, USA"],"affiliations":[{"raw_affiliation_string":"University of California, Santa Barbara, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100422437","display_name":"Zhen Wang","orcid":"https://orcid.org/0000-0003-4319-5314"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Wang","raw_affiliation_strings":["ShangHai Mental Health Center, Shanghai JiaoTong University, School of Medicine, P. R. China"],"affiliations":[{"raw_affiliation_string":"ShangHai Mental Health Center, Shanghai JiaoTong University, School of Medicine, P. R. China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5114672877"],"corresponding_institution_ids":["https://openalex.org/I181326427"],"apc_list":null,"apc_paid":null,"fwci":0.5685,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64685178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"22","issue":"06","first_page":"2450025","last_page":"2450025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9596999883651733,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.6408235430717468},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5715020298957825},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5207781195640564},{"id":"https://openalex.org/keywords/stress","display_name":"Stress (linguistics)","score":0.43648481369018555},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.4323006868362427},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4172561764717102},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.37967732548713684},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1388741135597229}],"concepts":[{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.6408235430717468},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5715020298957825},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5207781195640564},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.43648481369018555},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4323006868362427},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4172561764717102},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.37967732548713684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1388741135597229},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720024500252","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720024500252","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:39545813","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39545813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1576283994","https://openalex.org/W2053039860","https://openalex.org/W2096057003","https://openalex.org/W2135727958","https://openalex.org/W2139657351","https://openalex.org/W2150430982","https://openalex.org/W2336476615","https://openalex.org/W2413391237","https://openalex.org/W2462592197","https://openalex.org/W2463195069","https://openalex.org/W2612690371","https://openalex.org/W2756023329","https://openalex.org/W2806150378","https://openalex.org/W2921658448","https://openalex.org/W2927762831","https://openalex.org/W2945525532","https://openalex.org/W2948325153","https://openalex.org/W2999616751","https://openalex.org/W3005703146","https://openalex.org/W3008102555","https://openalex.org/W3016487203","https://openalex.org/W3035060204","https://openalex.org/W3089296243","https://openalex.org/W3097047630","https://openalex.org/W3120560541","https://openalex.org/W3134429428","https://openalex.org/W3167736274","https://openalex.org/W3179726909","https://openalex.org/W3183094718","https://openalex.org/W3213949234","https://openalex.org/W4200544542","https://openalex.org/W4210706440","https://openalex.org/W4214807529","https://openalex.org/W4224304232","https://openalex.org/W4225684354","https://openalex.org/W4292466623"],"related_works":["https://openalex.org/W2090763504","https://openalex.org/W1539981706","https://openalex.org/W1485011350","https://openalex.org/W4233701783","https://openalex.org/W2031369865","https://openalex.org/W1969295409","https://openalex.org/W2010715465","https://openalex.org/W2558197048","https://openalex.org/W1999883774","https://openalex.org/W2062711653"],"abstract_inverted_index":{"Research":[0],"suggests":[1],"that":[2,137],"individuals":[3],"who":[4],"experience":[5],"prolonged":[6],"exposure":[7],"to":[8,36,48,92,184],"stress":[9,18,22,62,98,182,187],"may":[10,33,175],"be":[11,34],"at":[12],"higher":[13],"risk":[14],"for":[15,56,76,96,180],"developing":[16],"psychological":[17,21,61,97,186],"disorders.":[19,188],"Currently,":[20],"is":[23,46],"primarily":[24],"evaluated":[25],"by":[26],"professional":[27],"physicians":[28],"using":[29,128],"rating":[30],"scales,":[31],"which":[32],"prone":[35],"subjective":[37],"biases":[38],"and":[39,53,80,109,133,143,166],"limitations":[40],"of":[41,60,113,125,131,140,153,158,164,170],"the":[42,58,119,126,134,138,150],"scales.":[43],"Therefore,":[44,172],"it":[45],"imperative":[47],"explore":[49],"more":[50],"objective,":[51],"accurate,":[52],"efficient":[54],"biomarkers":[55,95,127],"evaluating":[57],"level":[59],"in":[63],"an":[64,146,155,160,167],"individual.":[65],"In":[66],"this":[67,173],"study,":[68],"we":[69],"utilized":[70],"4D":[71],"data-independent":[72],"acquisition":[73],"(4D-DIA)":[74],"proteomics":[75],"quantitative":[77],"protein":[78],"analysis,":[79],"then":[81],"employed":[82],"support":[83],"vector":[84],"machine":[85,106],"(SVM)":[86],"combined":[87],"with":[88],"SHAP":[89],"interpretation":[90],"algorithm":[91],"identify":[93],"potential":[94,178],"levels.":[99],"Biomarkers":[100],"validation":[101],"was":[102],"subsequently":[103],"achieved":[104],"through":[105],"learning":[107],"classification":[108],"a":[110,114,177],"substantial":[111],"amount":[112],"priori":[115],"knowledge":[116,120],"derived":[117],"from":[118],"graph.":[121],"We":[122],"performed":[123],"cross-validation":[124],"two":[129],"batches":[130],"data,":[132],"results":[135],"showed":[136],"combination":[139,174],"Glyceraldehyde-3-phosphate":[141],"dehydrogenase":[142],"Fibronectin":[144],"yielded":[145],"average":[147,156,161,168],"area":[148],"under":[149],"curve":[151],"(AUC)":[152],"92%,":[154],"accuracy":[157],"86%,":[159],"F1":[162],"score":[163],"79%,":[165],"sensitivity":[169],"83%.":[171],"represent":[176],"approach":[179],"detecting":[181],"levels":[183],"prevent":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}