{"id":"https://openalex.org/W4402498823","doi":"https://doi.org/10.1142/s0219720024500240","title":"Improving drug\u2013target interaction prediction through dual-modality fusion with InteractNet","display_name":"Improving drug\u2013target interaction prediction through dual-modality fusion with InteractNet","publication_year":2024,"publication_date":"2024-09-12","ids":{"openalex":"https://openalex.org/W4402498823","doi":"https://doi.org/10.1142/s0219720024500240","pmid":"https://pubmed.ncbi.nlm.nih.gov/39573831"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720024500240","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720024500240","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111489850","display_name":"Baozhong Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Baozhong Zhu","raw_affiliation_strings":["School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China"],"raw_orcid":"https://orcid.org/0009-0004-6137-9066","affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114752841","display_name":"Runhua Zhang","orcid":"https://orcid.org/0009-0009-7516-0299"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runhua Zhang","raw_affiliation_strings":["School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China"],"raw_orcid":"https://orcid.org/0009-0009-7516-0299","affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000503636","display_name":"Tengsheng Jiang","orcid":"https://orcid.org/0009-0003-2013-468X"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tengsheng Jiang","raw_affiliation_strings":["Gusu School, Nanjing Medical University, Su Zhou 215009, P. R. China"],"raw_orcid":"https://orcid.org/0009-0003-2013-468X","affiliations":[{"raw_affiliation_string":"Gusu School, Nanjing Medical University, Su Zhou 215009, P. R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100602190","display_name":"Zhiming Cui","orcid":"https://orcid.org/0000-0002-2960-2051"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiming Cui","raw_affiliation_strings":["School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-2960-2051","affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103539455","display_name":"Jing Chen","orcid":"https://orcid.org/0009-0001-6510-1211"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":["School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China"],"raw_orcid":"https://orcid.org/0009-0001-6510-1211","affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076525932","display_name":"Hongjie Wu","orcid":"https://orcid.org/0000-0001-5921-8707"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjie Wu","raw_affiliation_strings":["School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-5921-8707","affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Suzhou University of Science and Technology, Su Zhou 215009, P. R. China","institution_ids":["https://openalex.org/I308837"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5111489850"],"corresponding_institution_ids":["https://openalex.org/I308837"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17750313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"05","first_page":"2450024","last_page":"2450024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9480000138282776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.6311459541320801},{"id":"https://openalex.org/keywords/dual","display_name":"Dual (grammatical number)","score":0.6088904738426208},{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.567478597164154},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5590648651123047},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49833226203918457},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4189668893814087},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4126235246658325},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3751241862773895},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21189546585083008},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.15447962284088135}],"concepts":[{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.6311459541320801},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.6088904738426208},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.567478597164154},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5590648651123047},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49833226203918457},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4189668893814087},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4126235246658325},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3751241862773895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21189546585083008},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15447962284088135},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720024500240","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720024500240","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:39573831","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39573831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1993285168","https://openalex.org/W2059471041","https://openalex.org/W2148145769","https://openalex.org/W2148512505","https://openalex.org/W2512408629","https://openalex.org/W2809216727","https://openalex.org/W2969996838","https://openalex.org/W2978484973","https://openalex.org/W3011478582","https://openalex.org/W3021338900","https://openalex.org/W3040724447","https://openalex.org/W3085429933","https://openalex.org/W3120801559","https://openalex.org/W3157142061","https://openalex.org/W3193921017","https://openalex.org/W4220982535","https://openalex.org/W4281742771","https://openalex.org/W4285041843","https://openalex.org/W4285414302","https://openalex.org/W4307722378","https://openalex.org/W4323042515","https://openalex.org/W4380986962","https://openalex.org/W4391347933","https://openalex.org/W4393092671","https://openalex.org/W4400472046"],"related_works":["https://openalex.org/W2385859805","https://openalex.org/W2530972254","https://openalex.org/W2374013449","https://openalex.org/W73545470","https://openalex.org/W2364381299","https://openalex.org/W2374430585","https://openalex.org/W3144423903","https://openalex.org/W2377397762","https://openalex.org/W2793967660","https://openalex.org/W2361654993"],"abstract_inverted_index":{"In":[0,125],"the":[1,14,44,65,100,142],"drug":[2],"discovery":[3],"process,":[4],"accurate":[5],"prediction":[6],"of":[7,16,50],"drug-target":[8],"interactions":[9],"is":[10],"crucial":[11],"to":[12,52,82],"accelerate":[13],"development":[15],"new":[17,38,138],"drugs.":[18],"However,":[19],"existing":[20],"methods":[21,121],"still":[22],"face":[23],"many":[24],"challenges":[25],"in":[26,122],"dealing":[27],"with":[28,99],"complex":[29,143],"biomolecular":[30],"interactions.":[31],"To":[32],"this":[33],"end,":[34],"we":[35],"propose":[36],"a":[37,78],"deep":[39],"learning":[40,116],"framework":[41,61],"that":[42,84,109],"combines":[43],"structural":[45],"information":[46],"and":[47,71,96,117,132,147],"sequence":[48],"features":[49,95],"proteins":[51],"provide":[53],"comprehensive":[54],"feature":[55],"representation":[56],"through":[57],"bimodal":[58],"fusion.":[59],"This":[60],"not":[62],"only":[63],"integrates":[64],"topological":[66],"adaptive":[67],"graph":[68,118],"convolutional":[69],"network":[70,120],"multi-head":[72],"attention":[73,80],"mechanism,":[74],"but":[75],"also":[76],"introduces":[77],"self-masked":[79],"mechanism":[81],"ensure":[83],"each":[85],"protein":[86],"binding":[87],"site":[88],"can":[89,129],"focus":[90],"on":[91,104],"its":[92,97],"own":[93],"unique":[94],"interaction":[98],"ligand.":[101],"Experimental":[102],"results":[103],"multiple":[105],"public":[106],"datasets":[107],"show":[108],"our":[110,127],"method":[111,128],"significantly":[112],"outperforms":[113],"traditional":[114],"machine":[115],"neural":[119],"predictive":[123],"performance.":[124],"addition,":[126],"effectively":[130],"identify":[131],"explain":[133],"key":[134],"molecular":[135],"interactions,":[136],"providing":[137],"insights":[139],"into":[140],"understanding":[141],"relationship":[144],"between":[145],"drugs":[146],"targets.":[148]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
