{"id":"https://openalex.org/W4397003240","doi":"https://doi.org/10.1142/s0219720024500112","title":"Body plan evolvability: The role of variability in gene regulatory networks","display_name":"Body plan evolvability: The role of variability in gene regulatory networks","publication_year":2024,"publication_date":"2024-05-17","ids":{"openalex":"https://openalex.org/W4397003240","doi":"https://doi.org/10.1142/s0219720024500112","pmid":"https://pubmed.ncbi.nlm.nih.gov/39036846"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720024500112","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720024500112","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002399513","display_name":"Alexander V. Spirov","orcid":"https://orcid.org/0000-0002-0509-6203"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexander V. Spirov","raw_affiliation_strings":["Lab Modeling of Evolution, I.\u00a0M.\u00a0Sechenov Institute of Evolutionary Physiology & Biochemistry, Russian Academy of Sciences, Thorez Pr. 44, St. Petersburg 2194223, Russia"],"affiliations":[{"raw_affiliation_string":"Lab Modeling of Evolution, I.\u00a0M.\u00a0Sechenov Institute of Evolutionary Physiology & Biochemistry, Russian Academy of Sciences, Thorez Pr. 44, St. Petersburg 2194223, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048711176","display_name":"Ekaterina Myasnikova","orcid":"https://orcid.org/0000-0001-6301-1012"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina M. Myasnikova","raw_affiliation_strings":["Lab Modeling of Evolution, I.\u00a0M.\u00a0Sechenov Institute of Evolutionary Physiology & Biochemistry, Russian Academy of Sciences, Thorez Pr. 44, St. Petersburg 2194223, Russia"],"affiliations":[{"raw_affiliation_string":"Lab Modeling of Evolution, I.\u00a0M.\u00a0Sechenov Institute of Evolutionary Physiology & Biochemistry, Russian Academy of Sciences, Thorez Pr. 44, St. Petersburg 2194223, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024247574","display_name":"David M. Holloway","orcid":"https://orcid.org/0000-0002-3865-0725"},"institutions":[{"id":"https://openalex.org/I174167972","display_name":"British Columbia Institute of Technology","ror":"https://ror.org/01p65pg69","country_code":"CA","type":"education","lineage":["https://openalex.org/I174167972"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David M. Holloway","raw_affiliation_strings":["Mathematics Department, British Columbia Institute of Technology, 3700 Willingdon Ave., Burnaby, B.C.\u00a0V5G 3H2, Canada"],"affiliations":[{"raw_affiliation_string":"Mathematics Department, British Columbia Institute of Technology, 3700 Willingdon Ave., Burnaby, B.C.\u00a0V5G 3H2, Canada","institution_ids":["https://openalex.org/I174167972"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002399513"],"corresponding_institution_ids":["https://openalex.org/I163234304"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08080529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"03","first_page":"2450011","last_page":"2450011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.751800000667572,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.751800000667572,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.722599983215332,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.708299994468689,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evolvability","display_name":"Evolvability","score":0.7979102730751038},{"id":"https://openalex.org/keywords/body-plan","display_name":"Body plan","score":0.6695114970207214},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5421037077903748},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.534244954586029},{"id":"https://openalex.org/keywords/plan","display_name":"Plan (archaeology)","score":0.47621139883995056},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46573320031166077},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4420340359210968},{"id":"https://openalex.org/keywords/regulator-gene","display_name":"Regulator gene","score":0.42957401275634766},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39936161041259766},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.35190245509147644},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.28672516345977783},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.17456313967704773}],"concepts":[{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.7979102730751038},{"id":"https://openalex.org/C148737382","wikidata":"https://www.wikidata.org/wiki/Q32831","display_name":"Body plan","level":3,"score":0.6695114970207214},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5421037077903748},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.534244954586029},{"id":"https://openalex.org/C2776505523","wikidata":"https://www.wikidata.org/wiki/Q4785468","display_name":"Plan (archaeology)","level":2,"score":0.47621139883995056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46573320031166077},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4420340359210968},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.42957401275634766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39936161041259766},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.35190245509147644},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28672516345977783},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17456313967704773},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720024500112","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720024500112","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:39036846","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39036846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W828602743","https://openalex.org/W1576847343","https://openalex.org/W1729182382","https://openalex.org/W1881244023","https://openalex.org/W1973081915","https://openalex.org/W1980265918","https://openalex.org/W1982583288","https://openalex.org/W1985644011","https://openalex.org/W1987471677","https://openalex.org/W1991484745","https://openalex.org/W1994664102","https://openalex.org/W1998008148","https://openalex.org/W2002797053","https://openalex.org/W2004289452","https://openalex.org/W2005098056","https://openalex.org/W2006413392","https://openalex.org/W2008608932","https://openalex.org/W2010795839","https://openalex.org/W2014584925","https://openalex.org/W2017061894","https://openalex.org/W2018881990","https://openalex.org/W2019562739","https://openalex.org/W2021185324","https://openalex.org/W2022692021","https://openalex.org/W2022851401","https://openalex.org/W2028443325","https://openalex.org/W2031830181","https://openalex.org/W2034149338","https://openalex.org/W2036283188","https://openalex.org/W2036338631","https://openalex.org/W2038701440","https://openalex.org/W2040167909","https://openalex.org/W2053076760","https://openalex.org/W2054257792","https://openalex.org/W2056599406","https://openalex.org/W2058942402","https://openalex.org/W2060915805","https://openalex.org/W2068721164","https://openalex.org/W2069614478","https://openalex.org/W2073580040","https://openalex.org/W2073761355","https://openalex.org/W2073881036","https://openalex.org/W2077210071","https://openalex.org/W2083034544","https://openalex.org/W2091908170","https://openalex.org/W2093049599","https://openalex.org/W2094902224","https://openalex.org/W2097950066","https://openalex.org/W2101283560","https://openalex.org/W2102216585","https://openalex.org/W2102744682","https://openalex.org/W2103957060","https://openalex.org/W2105293708","https://openalex.org/W2105557836","https://openalex.org/W2109571753","https://openalex.org/W2111011458","https://openalex.org/W2111857816","https://openalex.org/W2115097628","https://openalex.org/W2116015974","https://openalex.org/W2118300494","https://openalex.org/W2126664377","https://openalex.org/W2137057693","https://openalex.org/W2140374809","https://openalex.org/W2142170851","https://openalex.org/W2143368326","https://openalex.org/W2149994559","https://openalex.org/W2156375169","https://openalex.org/W2158047579","https://openalex.org/W2158092584","https://openalex.org/W2158560625","https://openalex.org/W2162669522","https://openalex.org/W2232394448","https://openalex.org/W2336180071","https://openalex.org/W2406651257","https://openalex.org/W2410775666","https://openalex.org/W2775939089","https://openalex.org/W2783956319","https://openalex.org/W2784846715","https://openalex.org/W2788022045","https://openalex.org/W2789595479","https://openalex.org/W2792350083","https://openalex.org/W2883761759","https://openalex.org/W2884105770","https://openalex.org/W2886502301","https://openalex.org/W2949348481","https://openalex.org/W2963948130","https://openalex.org/W2981298022","https://openalex.org/W3026990722","https://openalex.org/W3122143681","https://openalex.org/W3199070996","https://openalex.org/W4205347066","https://openalex.org/W4220808107","https://openalex.org/W4229568525","https://openalex.org/W4240580472","https://openalex.org/W4388657978"],"related_works":["https://openalex.org/W1978043574","https://openalex.org/W1681307731","https://openalex.org/W2077175850","https://openalex.org/W2068124679","https://openalex.org/W2157857537","https://openalex.org/W4298064144","https://openalex.org/W4232803304","https://openalex.org/W2073613683","https://openalex.org/W2484944091","https://openalex.org/W1969499963"],"abstract_inverted_index":{"Recent":[0],"computational":[1],"modeling":[2,70],"of":[3,29,34,71,148,154,161,190,222,230,233,239,260,268],"early":[4],"fruit":[5],"fly":[6],"(<i>Drosophila</i>)":[7],"development":[8],"has":[9,96],"characterized":[10],"the":[11,25,47,66,72,106,127,136,141,146,158,162,170,180,202,220,231,247,254],"degree":[12],"to":[13,21,83,144,178,195,263],"which":[14,101,174,244],"gene":[15,55,171],"regulation":[16],"networks":[17],"can":[18,120],"be":[19],"robust":[20],"natural":[22],"variability.":[23],"In":[24,135],"first":[26],"few":[27],"hours":[28],"development,":[30],"broad":[31],"spatial":[32,63],"gradients":[33],"maternally":[35],"derived":[36],"transcription":[37],"factors":[38],"activate":[39],"embryonic":[40],"gap":[41,44,215],"genes.":[42],"These":[43],"patterns":[45],"determine":[46],"subsequent":[48],"segmented":[49],"insect":[50,234],"body":[51,113],"plan":[52],"through":[53],"pair-rule":[54],"expression.":[56],"Gap":[57],"genes":[58],"are":[59,165,175,192],"expressed":[60],"with":[61],"greater":[62],"precision":[64],"than":[65],"maternal":[67,84,205],"patterns.":[68],"Computational":[69],"gap-gap":[73],"regulatory":[74,172],"interactions":[75],"provides":[76],"a":[77,99,121,213,265],"mechanistic":[78],"understanding":[79],"for":[80,256],"this":[81],"robustness":[82,185],"variability":[85,155],"in":[86,93,169,207,219,228,237],"wild-type":[87],"(WT)":[88],"patterning.":[89],"A":[90],"long-standing":[91],"question":[92],"evolutionary":[94],"biology":[95],"been":[97],"how":[98,119],"system":[100,122,159],"is":[102,115,130,186],"robust,":[103],"such":[104,149],"as":[105],"developmental":[107],"program":[108],"creating":[109],"any":[110],"particular":[111,167],"species'":[112],"plan,":[114],"also":[116],"evolvable,":[117],"i.e.":[118],"evolve":[123],"or":[124],"speciate,":[125],"if":[126],"WT":[128,142,163,181],"form":[129],"strongly":[131],"buffered":[132],"and":[133,183,236,242],"protected?":[134],"present":[137],"work,":[138],"we":[139,211],"use":[140],"model":[143,248],"explore":[145],"breakdown":[147],"Waddington-type":[150],"'canalization'.":[151],"What":[152],"levels":[153],"will":[156],"push":[157],"out":[160],"form;":[164,182],"there":[166],"pathways":[168],"mechanism":[173],"more":[176],"susceptible":[177],"losing":[179],"when":[184],"lost,":[187],"what":[188,198],"types":[189],"forms":[191,199],"most":[193],"likely":[194],"occur":[196],"(i.e.":[197],"lie":[200],"near":[201],"WT)?":[203],"Manipulating":[204],"effects":[206],"several":[208],"different":[209],"pathways,":[210],"find":[212],"common":[214],"'peak-to-step'":[216],"pattern":[217,261],"transition":[218],"loss":[221],"WT.":[223],"We":[224,250],"discuss":[225],"these":[226],"results":[227],"terms":[229,238],"evolvability":[232],"segmentation,":[235],"experimental":[240],"perturbations":[241],"mutations":[243],"could":[245],"test":[246],"predictions.":[249],"conclude":[251],"by":[252],"discussing":[253],"prospects":[255],"using":[257],"continuum":[258],"models":[259],"dynamics":[262],"investigate":[264],"wider":[266],"range":[267],"evo-devo":[269],"problems.":[270]},"counts_by_year":[],"updated_date":"2025-12-21T01:58:51.020947","created_date":"2025-10-10T00:00:00"}
