{"id":"https://openalex.org/W3190568014","doi":"https://doi.org/10.1142/s0219720021500219","title":"HemoNet: Predicting hemolytic activity of peptides with integrated feature learning","display_name":"HemoNet: Predicting hemolytic activity of peptides with integrated feature learning","publication_year":2021,"publication_date":"2021-08-05","ids":{"openalex":"https://openalex.org/W3190568014","doi":"https://doi.org/10.1142/s0219720021500219","mag":"3190568014","pmid":"https://pubmed.ncbi.nlm.nih.gov/34353244"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720021500219","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720021500219","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058797103","display_name":"Adiba Yaseen","orcid":"https://orcid.org/0000-0001-6794-1364"},"institutions":[{"id":"https://openalex.org/I134276161","display_name":"Pakistan Institute of Engineering and Applied Sciences","ror":"https://ror.org/04d4mbk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I134276161"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Adiba Yaseen","raw_affiliation_strings":["Department of Computer and Information Science, Pakistan Institute of Engineering and Applied Science (PIEAS), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science, Pakistan Institute of Engineering and Applied Science (PIEAS), Islamabad, Pakistan","institution_ids":["https://openalex.org/I134276161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066299009","display_name":"Sadaf Gull","orcid":null},"institutions":[{"id":"https://openalex.org/I134276161","display_name":"Pakistan Institute of Engineering and Applied Sciences","ror":"https://ror.org/04d4mbk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I134276161"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sadaf Gull","raw_affiliation_strings":["Department of Computer and Information Science, Pakistan Institute of Engineering and Applied Science (PIEAS), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science, Pakistan Institute of Engineering and Applied Science (PIEAS), Islamabad, Pakistan","institution_ids":["https://openalex.org/I134276161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017225838","display_name":"Naeem Akhtar","orcid":"https://orcid.org/0000-0002-6756-2898"},"institutions":[{"id":"https://openalex.org/I134276161","display_name":"Pakistan Institute of Engineering and Applied Sciences","ror":"https://ror.org/04d4mbk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I134276161"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Naeem Akhtar","raw_affiliation_strings":["Department of Computer and Information Science, Pakistan Institute of Engineering and Applied Science (PIEAS), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science, Pakistan Institute of Engineering and Applied Science (PIEAS), Islamabad, Pakistan","institution_ids":["https://openalex.org/I134276161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060659437","display_name":"Imran Amin","orcid":"https://orcid.org/0000-0003-3063-4103"},"institutions":[{"id":"https://openalex.org/I1308171952","display_name":"National Institute for Biotechnology and Genetic Engineering","ror":"https://ror.org/01bh91531","country_code":"PK","type":"education","lineage":["https://openalex.org/I1308171952"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Imran Amin","raw_affiliation_strings":["National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan","institution_ids":["https://openalex.org/I1308171952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086173090","display_name":"Fayyaz Minhas","orcid":"https://orcid.org/0000-0001-9129-1189"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Fayyaz Minhas","raw_affiliation_strings":["Department of Computer Science, University of Warwick, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086173090"],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":null,"apc_paid":null,"fwci":2.7766,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.91062876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"05","first_page":"2150021","last_page":"2150021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.605843186378479},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.603380560874939},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5198031663894653},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.48597562313079834},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4699285924434662},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44980067014694214},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.44774821400642395},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3318021297454834},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17410865426063538}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.605843186378479},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.603380560874939},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5198031663894653},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.48597562313079834},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4699285924434662},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44980067014694214},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.44774821400642395},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3318021297454834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17410865426063538},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1142/s0219720021500219","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720021500219","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:34353244","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34353244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:wrap.warwick.ac.uk:158172","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G586013047","display_name":null,"funder_award_id":"NRPU 6085","funder_id":"https://openalex.org/F4320322799","funder_display_name":"Higher Education Commission, Pakistan"}],"funders":[{"id":"https://openalex.org/F4320322799","display_name":"Higher Education Commission, Pakistan","ror":"https://ror.org/038y3sz68"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1549656520","https://openalex.org/W1974126272","https://openalex.org/W1976526581","https://openalex.org/W1981276685","https://openalex.org/W1990000747","https://openalex.org/W1992450378","https://openalex.org/W2038294548","https://openalex.org/W2050000500","https://openalex.org/W2055043387","https://openalex.org/W2065139121","https://openalex.org/W2072754176","https://openalex.org/W2080614447","https://openalex.org/W2090286010","https://openalex.org/W2097606916","https://openalex.org/W2113442785","https://openalex.org/W2122553352","https://openalex.org/W2177317049","https://openalex.org/W2222575139","https://openalex.org/W2261189595","https://openalex.org/W2337903860","https://openalex.org/W2403156809","https://openalex.org/W2418882863","https://openalex.org/W2549976854","https://openalex.org/W2580767461","https://openalex.org/W2589065420","https://openalex.org/W2590235073","https://openalex.org/W2724823461","https://openalex.org/W2725088538","https://openalex.org/W2739980134","https://openalex.org/W2754882069","https://openalex.org/W2766462472","https://openalex.org/W2788314593","https://openalex.org/W2792986592","https://openalex.org/W2899092808","https://openalex.org/W2920549496","https://openalex.org/W2936970738","https://openalex.org/W2947296233","https://openalex.org/W2965128681","https://openalex.org/W2979683806","https://openalex.org/W2984088161","https://openalex.org/W2986071217","https://openalex.org/W2992070886","https://openalex.org/W2995514860","https://openalex.org/W3007202177","https://openalex.org/W3009548091","https://openalex.org/W3010275135","https://openalex.org/W3013436991","https://openalex.org/W3014033160","https://openalex.org/W3030391949","https://openalex.org/W3037095905","https://openalex.org/W3039894784","https://openalex.org/W3048411531","https://openalex.org/W3087735644","https://openalex.org/W3088952809","https://openalex.org/W3089066960","https://openalex.org/W3102511045"],"related_works":["https://openalex.org/W2081900870","https://openalex.org/W2037549926","https://openalex.org/W2345479200","https://openalex.org/W2183306018","https://openalex.org/W2849310602","https://openalex.org/W3006008237","https://openalex.org/W2419146053","https://openalex.org/W4388890789","https://openalex.org/W2088247287","https://openalex.org/W2963903416"],"abstract_inverted_index":{"Quantifying":[0],"the":[1,11,59,85,94,123,127,154,184,194,200],"hemolytic":[2,40,86],"activity":[3,87],"of":[4,13,35,53,61,88,97,117,126,163,175,193],"peptides":[5,36,146],"is":[6,197],"a":[7,76,102,107,180],"crucial":[8],"step":[9],"in":[10,21,101,111,133,165,183],"discovery":[12,32],"novel":[14,77,187],"therapeutic":[15,188],"peptides.":[16,89,150,189],"Computational":[17],"methods":[18,44],"are":[19,45],"attractive":[20],"this":[22,54,71],"domain":[23],"due":[24],"to":[25,28,47,167],"their":[26,39],"ability":[27],"guide":[29],"wet-lab":[30],"experimental":[31],"or":[33],"screening":[34],"based":[37],"on":[38,144],"activity.":[41],"However,":[42],"existing":[43],"unable":[46],"accurately":[48],"model":[49],"various":[50],"important":[51],"aspects":[52],"predictive":[55,124,160],"problem":[56],"such":[57],"as":[58,140,142],"role":[60],"N/C-terminal":[62,118],"modifications,":[63],"D-":[64],"and":[65,147,171],"L-":[66],"amino":[67,99],"acids,":[68],"etc.":[69],"In":[70],"work,":[72],"we":[73],"have":[74,121],"developed":[75],"neural":[78],"network-based":[79],"approach":[80,156],"called":[81],"HemoNet":[82,177],"for":[83,186],"predicting":[84],"The":[90,190],"proposed":[91,128,155,195],"method":[92,129,196],"captures":[93],"contextual":[95],"importance":[96],"different":[98],"acids":[100],"given":[103],"peptide":[104],"sequence":[105],"using":[106,130],"specialized":[108],"feature":[109],"embedding":[110],"conjunction":[112],"with":[113,135,173],"SMILES-based":[114],"fingerprint":[115],"representation":[116],"modifications.":[119],"We":[120],"analyzed":[122],"performance":[125,161],"stratified":[131],"cross-validation":[132,139],"comparison":[134,166],"previous":[136,168],"methods,":[137],"non-redundant":[138],"well":[141],"validation":[143],"external":[145],"clinical":[148],"antimicrobial":[149],"Our":[151],"analysis":[152],"shows":[153],"achieves":[157],"significantly":[158],"better":[159],"(AUC-ROC":[162],"88%)":[164],"approaches":[169],"(HemoPI":[170],"HemoPred":[172],"AUC-ROC":[174],"73%).":[176],"can":[178],"be":[179],"useful":[181],"tool":[182],"search":[185],"python":[191],"implementation":[192],"available":[198],"at":[199],"URL:":[201],"https://github.com/adibayaseen/HemoNet.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}