{"id":"https://openalex.org/W3036307273","doi":"https://doi.org/10.1142/s0219720020400065","title":"Cell cycle period control through modulation of clock inputs","display_name":"Cell cycle period control through modulation of clock inputs","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3036307273","doi":"https://doi.org/10.1142/s0219720020400065","mag":"3036307273","pmid":"https://pubmed.ncbi.nlm.nih.gov/32552242"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720020400065","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720020400065","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027153557","display_name":"Sofia Almeida","orcid":"https://orcid.org/0000-0002-7547-8784"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Almeida","raw_affiliation_strings":["Inria, iBV, Universit\u00e9 C\u00f4te d\u2019Azur, Sophia Antipolis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria, iBV, Universit\u00e9 C\u00f4te d\u2019Azur, Sophia Antipolis, France","institution_ids":["https://openalex.org/I1326498283","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024047053","display_name":"Madalena Chaves","orcid":"https://orcid.org/0000-0003-0647-9254"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Chaves","raw_affiliation_strings":["Inria, Universit\u00e9 C\u00f4te d\u2019Azur, INRA, CNRS, Sorbonne Universit\u00e9, Sophia Antipolis, France","BIOCORE - Biological control of artificial ecosystems (2004 route des Lucioles 06902 Sophia Antipolis - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria, Universit\u00e9 C\u00f4te d\u2019Azur, INRA, CNRS, Sorbonne Universit\u00e9, Sophia Antipolis, France","institution_ids":["https://openalex.org/I1326498283","https://openalex.org/I201841394","https://openalex.org/I39804081","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"BIOCORE - Biological control of artificial ecosystems (2004 route des Lucioles 06902 Sophia Antipolis - France)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010951327","display_name":"Franck Delaunay","orcid":"https://orcid.org/0000-0003-4927-1701"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Delaunay","raw_affiliation_strings":["iBV, Universit\u00e9 C\u00f4te d\u2019Azur, CNRS, INSERM, Sophia Antipolis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iBV, Universit\u00e9 C\u00f4te d\u2019Azur, CNRS, INSERM, Sophia Antipolis, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8869,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80024378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"18","issue":"03","first_page":"2040006","last_page":"2040006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wee1","display_name":"Wee1","score":0.8128632307052612},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.6852312088012695},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5524729490280151},{"id":"https://openalex.org/keywords/cell-synchronization","display_name":"Cell synchronization","score":0.4970379173755646},{"id":"https://openalex.org/keywords/clock-synchronization","display_name":"Clock synchronization","score":0.4880277216434479},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"Circadian clock","score":0.4789462685585022},{"id":"https://openalex.org/keywords/clock-domain-crossing","display_name":"Clock domain crossing","score":0.4657991826534271},{"id":"https://openalex.org/keywords/restriction-point","display_name":"Restriction point","score":0.44495195150375366},{"id":"https://openalex.org/keywords/cell-cycle-protein","display_name":"Cell Cycle Protein","score":0.42630457878112793},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3912937343120575},{"id":"https://openalex.org/keywords/clock-signal","display_name":"Clock signal","score":0.3002738952636719},{"id":"https://openalex.org/keywords/synchronization","display_name":"Synchronization (alternating current)","score":0.2977149486541748},{"id":"https://openalex.org/keywords/cyclin","display_name":"Cyclin","score":0.28276681900024414},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-1","display_name":"Cyclin-dependent kinase 1","score":0.2794390916824341},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2568363547325134},{"id":"https://openalex.org/keywords/synchronous-circuit","display_name":"Synchronous circuit","score":0.22858068346977234},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.22700512409210205},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19337353110313416}],"concepts":[{"id":"https://openalex.org/C2781252693","wikidata":"https://www.wikidata.org/wiki/Q7979264","display_name":"Wee1","level":5,"score":0.8128632307052612},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6852312088012695},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5524729490280151},{"id":"https://openalex.org/C88254577","wikidata":"https://www.wikidata.org/wiki/Q17113282","display_name":"Cell synchronization","level":4,"score":0.4970379173755646},{"id":"https://openalex.org/C129891060","wikidata":"https://www.wikidata.org/wiki/Q1513059","display_name":"Clock synchronization","level":4,"score":0.4880277216434479},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.4789462685585022},{"id":"https://openalex.org/C127204226","wikidata":"https://www.wikidata.org/wiki/Q5134799","display_name":"Clock domain crossing","level":5,"score":0.4657991826534271},{"id":"https://openalex.org/C152857842","wikidata":"https://www.wikidata.org/wiki/Q7316321","display_name":"Restriction point","level":5,"score":0.44495195150375366},{"id":"https://openalex.org/C2911011838","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell Cycle Protein","level":4,"score":0.42630457878112793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3912937343120575},{"id":"https://openalex.org/C137059387","wikidata":"https://www.wikidata.org/wiki/Q426882","display_name":"Clock signal","level":3,"score":0.3002738952636719},{"id":"https://openalex.org/C2778562939","wikidata":"https://www.wikidata.org/wiki/Q1298791","display_name":"Synchronization (alternating current)","level":3,"score":0.2977149486541748},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.28276681900024414},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.2794390916824341},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2568363547325134},{"id":"https://openalex.org/C42196554","wikidata":"https://www.wikidata.org/wiki/Q1186179","display_name":"Synchronous circuit","level":4,"score":0.22858068346977234},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22700512409210205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19337353110313416},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C134652429","wikidata":"https://www.wikidata.org/wiki/Q1052698","display_name":"Jitter","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016200","descriptor_name":"Maturation-Promoting Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016200","descriptor_name":"Maturation-Promoting Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016200","descriptor_name":"Maturation-Promoting Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051358","descriptor_name":"Cyclin-Dependent Kinase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051358","descriptor_name":"Cyclin-Dependent Kinase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051358","descriptor_name":"Cyclin-Dependent Kinase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056741","descriptor_name":"Cyclin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056741","descriptor_name":"Cyclin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056741","descriptor_name":"Cyclin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056926","descriptor_name":"CLOCK Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056926","descriptor_name":"CLOCK Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056926","descriptor_name":"CLOCK Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056930","descriptor_name":"ARNTL Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056930","descriptor_name":"ARNTL Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056930","descriptor_name":"ARNTL Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1142/s0219720020400065","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720020400065","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:32552242","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32552242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-03105546v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-03105546","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Bioinformatics and Computational Biology, 2020, 18 (03), pp.2040006. ⟨10.1142/S0219720020400065⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3449694119","display_name":"Interconnection and feedback control of two cyclic modules in mammalian cells","funder_award_id":"ANR-16-CE33-0016","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6838463990","display_name":"Hydrodynamics and radiation in galaxies of the early universe","funder_award_id":"ANR-14-CE33-0016","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8533281491","display_name":"R\u00e9seau d'Innovation sur les Voies de Signalisation en Sciences de la Vie","funder_award_id":"ANR-11-LABX-0028","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W649284901","https://openalex.org/W1985837106","https://openalex.org/W1986794485","https://openalex.org/W1991080086","https://openalex.org/W1997179110","https://openalex.org/W1997364930","https://openalex.org/W2003083671","https://openalex.org/W2021748681","https://openalex.org/W2038304337","https://openalex.org/W2040650438","https://openalex.org/W2084074983","https://openalex.org/W2095720556","https://openalex.org/W2113136381","https://openalex.org/W2129569342","https://openalex.org/W2136714385","https://openalex.org/W2161548459","https://openalex.org/W2169326906","https://openalex.org/W2330995965","https://openalex.org/W2476817834","https://openalex.org/W2606681577","https://openalex.org/W2766968224","https://openalex.org/W2974070076","https://openalex.org/W3006110622"],"related_works":["https://openalex.org/W3008092645","https://openalex.org/W2033424921","https://openalex.org/W2623248147","https://openalex.org/W4200203052","https://openalex.org/W2129260097","https://openalex.org/W2137134648","https://openalex.org/W2094440667","https://openalex.org/W3007812665","https://openalex.org/W3036307273","https://openalex.org/W148182554"],"abstract_inverted_index":{"In":[0],"this":[1],"work,":[2],"we":[3,20,93,119],"study":[4],"period":[5,164],"control":[6,44,165],"of":[7,23,31,40,45,61,75,90,98,123,132,144,147,163,178,183],"the":[8,15,24,34,38,46,58,62,67,72,80,87,99,133,172,176],"mammalian":[9],"cell":[10,35,47,82,102,115,135,150,173],"cycle":[11,36,48,83,103,116,136,151,174],"via":[12,52],"coupling":[13,88],"with":[14,37],"cellular":[16],"clock.":[17],"For":[18],"this,":[19],"make":[21],"use":[22,39,94,177],"oscillators\u2019":[25],"synchronization":[26],"dynamics":[27,89],"and":[28,101,105,158],"investigate":[29,86],"methods":[30],"slowing":[32,170],"down":[33,171],"clock":[41,100,111,148,179],"inputs.":[42],"Clock":[43],"is":[49],"well":[50],"established":[51],"identified":[53],"molecular":[54],"mechanisms,":[55],"such":[56,153],"as":[57],"CLOCK:BMAL1-mediated":[59],"induction":[60],"wee1":[63],"gene,":[64],"resulting":[65],"in":[66,168],"WEE1":[68],"kinase":[69],"that":[70],"represses":[71],"active":[73],"form":[74],"mitosis":[76],"promoting":[77],"factor":[78],"(MPF),":[79],"essential":[81],"component.":[84],"To":[85],"these":[91],"systems,":[92],"previously":[95],"developed":[96],"models":[97],"oscillators":[104],"center":[106],"our":[107,161],"studies":[108],"on":[109],"unidirectional":[110],"[Formula:":[112],"see":[113],"text]":[114],"coupling.":[117],"Moreover,":[118],"propose":[120],"an":[121],"hypothesis":[122],"a":[124,130,142],"Growth":[125],"Factor":[126],"(GF)-responsive":[127],"clock,":[128],"involving":[129],"pathway":[131],"non-essential":[134],"complex":[137],"cyclin":[138],"D/CDK4.":[139],"We":[140],"observe":[141],"variety":[143],"rational":[145],"ratios":[146],"to":[149,186],"period,":[152],"as:":[154],"1:1,":[155],"3:2,":[156],"4:3,":[157],"5:4.":[159],"Finally,":[160],"protocols":[162],"are":[166],"successful":[167],"effectively":[169],"by":[175],"modulating":[180],"inputs,":[181],"some":[182],"which":[184],"correspond":[185],"existing":[187],"drugs.":[188]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}