{"id":"https://openalex.org/W2980744353","doi":"https://doi.org/10.1142/s0219720019500355","title":"SIN-KNO: A method of gene regulatory network inference using single-cell transcription and gene knockout data","display_name":"SIN-KNO: A method of gene regulatory network inference using single-cell transcription and gene knockout data","publication_year":2019,"publication_date":"2019-10-14","ids":{"openalex":"https://openalex.org/W2980744353","doi":"https://doi.org/10.1142/s0219720019500355","mag":"2980744353","pmid":"https://pubmed.ncbi.nlm.nih.gov/32019417"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720019500355","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720019500355","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101815036","display_name":"Huiqing Wang","orcid":"https://orcid.org/0000-0001-8611-6546"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiqing Wang","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016606183","display_name":"Yuanyuan Lian","orcid":"https://orcid.org/0000-0001-7072-351X"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Lian","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":"https://orcid.org/0000-0001-7072-351X","affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371573","display_name":"Chun Li","orcid":"https://orcid.org/0000-0003-2311-3422"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Li","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020249585","display_name":"Yue Ma","orcid":"https://orcid.org/0000-0003-1362-3752"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Ma","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039584678","display_name":"Zhiliang Yan","orcid":"https://orcid.org/0000-0003-3435-0095"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiliang Yan","raw_affiliation_strings":["College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103033715","display_name":"Chunlin Dong","orcid":"https://orcid.org/0000-0001-9345-392X"},"institutions":[{"id":"https://openalex.org/I4210161131","display_name":"Shanxi Academy of Agricultural Sciences","ror":"https://ror.org/0570hy479","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210161131"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunlin Dong","raw_affiliation_strings":["Dryland Agriculture Research Center, Shanxi Academy of Agricultural Sciences, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dryland Agriculture Research Center, Shanxi Academy of Agricultural Sciences, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I4210161131"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101815036"],"corresponding_institution_ids":["https://openalex.org/I9086337"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09885197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"06","first_page":"1950035","last_page":"1950035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7535065412521362},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6108641028404236},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6003798842430115},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5960279107093811},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5833776593208313},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5727201700210571},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5229980945587158},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.49035143852233887},{"id":"https://openalex.org/keywords/gene-knockout","display_name":"Gene knockout","score":0.4710155725479126},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.4551132321357727},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3489859104156494},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.30503320693969727},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14198365807533264}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7535065412521362},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6108641028404236},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6003798842430115},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5960279107093811},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5833776593208313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5727201700210571},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5229980945587158},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.49035143852233887},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.4710155725479126},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4551132321357727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3489859104156494},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30503320693969727},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14198365807533264}],"mesh":[{"descriptor_ui":"D000078326","descriptor_name":"Data Visualization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078326","descriptor_name":"Data Visualization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078326","descriptor_name":"Data Visualization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720019500355","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720019500355","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:32019417","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32019417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1175879704","https://openalex.org/W1697828529","https://openalex.org/W1973268693","https://openalex.org/W1986911601","https://openalex.org/W1993418188","https://openalex.org/W1995031758","https://openalex.org/W2024209903","https://openalex.org/W2028288720","https://openalex.org/W2039521726","https://openalex.org/W2076513103","https://openalex.org/W2080619411","https://openalex.org/W2102969613","https://openalex.org/W2122175345","https://openalex.org/W2122982115","https://openalex.org/W2126345910","https://openalex.org/W2128227827","https://openalex.org/W2136453810","https://openalex.org/W2139997707","https://openalex.org/W2148944713","https://openalex.org/W2157252884","https://openalex.org/W2157581457","https://openalex.org/W2159567041","https://openalex.org/W2169353806","https://openalex.org/W2175406438","https://openalex.org/W2179438025","https://openalex.org/W2258294038","https://openalex.org/W2417908310","https://openalex.org/W2535035037","https://openalex.org/W2564574837","https://openalex.org/W2615816755","https://openalex.org/W2630377436","https://openalex.org/W2739241668","https://openalex.org/W2744465043","https://openalex.org/W2747545374","https://openalex.org/W2753908609","https://openalex.org/W2768663336","https://openalex.org/W2831482487","https://openalex.org/W2890423752","https://openalex.org/W2900099657","https://openalex.org/W2951850020","https://openalex.org/W2952535935","https://openalex.org/W2962898193","https://openalex.org/W2963189776"],"related_works":["https://openalex.org/W2560421304","https://openalex.org/W2950199998","https://openalex.org/W2951387065","https://openalex.org/W2134575910","https://openalex.org/W4385727351","https://openalex.org/W4306798985","https://openalex.org/W2091570353","https://openalex.org/W2010571965","https://openalex.org/W3128451840","https://openalex.org/W2002709996"],"abstract_inverted_index":{"As":[0],"a":[1,137,223,285,299],"tool":[2],"of":[3,52,59,72,96,106,123,132,163,204,226,233,264,282,311],"interpreting":[4],"and":[5,20,29,37,92,103,130,145,160,260,291,307],"analyzing":[6,217],"genetic":[7],"data,":[8,148,283],"gene":[9,61,73,146,168,178,188,199,210,288],"regulatory":[10,15,54,164],"network":[11],"(GRN)":[12],"could":[13,174,186,196,221],"reveal":[14],"relationships":[16,55],"between":[17],"genes,":[18],"proteins,":[19],"small":[21],"molecules,":[22],"as":[23,25],"well":[24],"understand":[26,176],"physiological":[27],"activities":[28],"functions":[30],"within":[31],"biological":[32],"cells,":[33],"interact":[34],"in":[35,42,115,167,181,254,278,314],"pathways,":[36],"how":[38],"to":[39,67,100,111,240],"make":[40],"changes":[41,190],"the":[43,50,53,57,69,93,107,113,121,177,198,214,218,231,242,244,265,269,274,279,293,315],"organism.":[44],"Traditional":[45],"GRN":[46,79,117,140,316],"research":[47],"focuses":[48,156],"on":[49,157],"analysis":[51],"through":[56],"average":[58],"cellular":[60,124],"expressions.":[62],"These":[63],"methods":[64,76,253],"are":[65],"difficult":[66],"identify":[68],"cell":[70,171],"heterogeneity":[71,125,172],"expression.":[74,169],"Existing":[75],"for":[77,139,236,302],"inferring":[78],"using":[80,142],"single-cell":[81,97,127,143,219,312],"transcriptional":[82],"data":[83,98,128,153,195,220,313],"lack":[84,122,131],"expression":[85,179,189,200],"information":[86,162,173,276],"when":[87,208],"genes":[88,207,215],"reach":[89],"steady":[90],"state,":[91],"high":[94,101,308],"dimensionality":[95],"leads":[99],"temporal":[102],"spatial":[104],"complexity":[105,129,310],"algorithm.":[108],"In":[109,238],"order":[110,239],"solve":[112],"problem":[114],"traditional":[116],"inference":[118,141],"methods,":[119],"including":[120,257],"information,":[126,134],"steady-state":[133,161,203],"we":[135,185],"propose":[136],"method":[138,246,271,297],"transcription":[144,151],"knockout":[147,194],"called":[149],"SINgle-cell":[150],"data-KNOckout":[152],"(SIN-KNO),":[154],"which":[155],"combining":[158],"dynamic":[159],"relationship":[165],"contained":[166,277],"Capturing":[170],"help":[175],"difference":[180],"different":[182],"cells.":[183],"So,":[184],"observe":[187,197],"more":[191,286],"accurately.":[192],"Gene":[193],"levels":[201],"at":[202],"all":[205],"other":[206],"one":[209],"is":[211],"knockout.":[212],"Classifying":[213],"before":[216],"determine":[222],"large":[224,305],"number":[225,232],"non-existent":[227],"regulation,":[228],"greatly":[229],"reducing":[230],"regulation":[234,289],"required":[235],"inference.":[237,317],"show":[241],"efficiency,":[243],"proposed":[245,270],"has":[247],"been":[248],"compared":[249],"with":[250,304],"several":[251],"typical":[252],"this":[255],"area":[256],"GENIE3,":[258],"JUMP3,":[259],"SINCERITIES.":[261],"The":[262,296],"results":[263],"evaluation":[266],"indicate":[267],"that":[268],"can":[272],"analyze":[273],"diversified":[275],"two":[280],"types":[281],"establish":[284],"accurate":[287],"network,":[290],"improve":[292],"computational":[294,309],"efficiency.":[295],"provides":[298],"new":[300],"thinking":[301],"dealing":[303],"datasets":[306]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}