{"id":"https://openalex.org/W2950144621","doi":"https://doi.org/10.1142/s0219720019500264","title":"Glycine-induced formation and druggability score prediction of protein surface pockets","display_name":"Glycine-induced formation and druggability score prediction of protein surface pockets","publication_year":2019,"publication_date":"2019-06-11","ids":{"openalex":"https://openalex.org/W2950144621","doi":"https://doi.org/10.1142/s0219720019500264","mag":"2950144621","pmid":"https://pubmed.ncbi.nlm.nih.gov/31744363"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720019500264","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720019500264","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068411561","display_name":"Pietro Bongini","orcid":"https://orcid.org/0000-0001-9074-0587"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pietro Bongini","raw_affiliation_strings":["Department of Information Engineering and Mathematics, University of Siena, via Roma 56, 53100, Siena, Italy","Department of Information Engineering, University of Florence, via S. Marta 3, 50139, Florence, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9074-0587","affiliations":[{"raw_affiliation_string":"Department of Information Engineering and Mathematics, University of Siena, via Roma 56, 53100, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Department of Information Engineering, University of Florence, via S. Marta 3, 50139, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044997014","display_name":"Neri Niccolai","orcid":"https://orcid.org/0000-0002-6919-6908"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Neri Niccolai","raw_affiliation_strings":["Department of Biotechnologies, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnologies, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091787895","display_name":"Monica Bianchini","orcid":"https://orcid.org/0000-0002-8206-8142"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Bianchini","raw_affiliation_strings":["Department of Information Engineering and Mathematics, University of Siena, via Roma 56, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering and Mathematics, University of Siena, via Roma 56, 53100, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068411561"],"corresponding_institution_ids":["https://openalex.org/I102064193","https://openalex.org/I45084792"],"apc_list":null,"apc_paid":null,"fwci":0.5983,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66756352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"17","issue":"05","first_page":"1950026","last_page":"1950026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.9821144342422485},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6269241571426392},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5126463770866394},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.48911887407302856},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.45296645164489746},{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.43896323442459106},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.386860728263855},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35049867630004883},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3220021426677704}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.9821144342422485},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6269241571426392},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5126463770866394},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.48911887407302856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45296645164489746},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.43896323442459106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.386860728263855},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35049867630004883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3220021426677704}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1142/s0219720019500264","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720019500264","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:31744363","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31744363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:usiena-air.unisi.it:11365/1080294","is_oa":false,"landing_page_url":"https://www.worldscientific.com/doi/10.1142/S0219720019500264","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1255705275","https://openalex.org/W1517566065","https://openalex.org/W1754973657","https://openalex.org/W1968278549","https://openalex.org/W1970799005","https://openalex.org/W1975304761","https://openalex.org/W1981064967","https://openalex.org/W1984563996","https://openalex.org/W1997172276","https://openalex.org/W2005136695","https://openalex.org/W2013309178","https://openalex.org/W2013600324","https://openalex.org/W2030753552","https://openalex.org/W2031194866","https://openalex.org/W2038210983","https://openalex.org/W2044703506","https://openalex.org/W2062884696","https://openalex.org/W2066672837","https://openalex.org/W2073746700","https://openalex.org/W2078409719","https://openalex.org/W2079953901","https://openalex.org/W2091563009","https://openalex.org/W2101234009","https://openalex.org/W2103111465","https://openalex.org/W2105902442","https://openalex.org/W2111762125","https://openalex.org/W2121003266","https://openalex.org/W2130479394","https://openalex.org/W2132727000","https://openalex.org/W2140407975","https://openalex.org/W2143908786","https://openalex.org/W2144714500","https://openalex.org/W2147421370","https://openalex.org/W2153504150","https://openalex.org/W2163816950","https://openalex.org/W2799327292","https://openalex.org/W2807983521"],"related_works":["https://openalex.org/W1969888071","https://openalex.org/W2035422779","https://openalex.org/W4389227606","https://openalex.org/W2925167008","https://openalex.org/W2036884070","https://openalex.org/W2008033400","https://openalex.org/W2903181389","https://openalex.org/W3023385275","https://openalex.org/W1972982874","https://openalex.org/W2538996250"],"abstract_inverted_index":{"Nowadays,":[0],"it":[1],"is":[2,58,77,138],"well":[3],"established":[4],"that":[5,210],"most":[6],"of":[7,31,52,62,73,83,87,105,129,143,149,198,212],"the":[8,29,39,50,71,84,110,127,141,147,182,195,213,217],"human":[9,67],"diseases":[10,99],"which":[11,150],"are":[12,124,155,159,170,206,220],"not":[13],"related":[14],"to":[15,41,47,65,97,118,193],"pathogen":[16],"infections":[17],"have":[18],"their":[19],"origin":[20],"from":[21],"DNA":[22,25,102],"disorders.":[23],"Thus,":[24],"mutations,":[26],"waiting":[27],"for":[28,140,162],"availability":[30],"CRISPR-like":[32],"remedies,":[33],"will":[34],"propagate":[35],"into":[36],"proteomics,":[37],"offering":[38],"possibility":[40],"select":[42],"natural":[43,184],"or":[44],"synthetic":[45],"molecules":[46],"fight":[48],"against":[49],"effects":[51,123],"malfunctioning":[53],"proteins.":[54],"Drug":[55],"discovery,":[56],"indeed,":[57],"a":[59,74,135,189],"flourishing":[60],"field":[61],"biotechnological":[63],"research":[64],"improve":[66],"health,":[68],"even":[69],"though":[70],"development":[72],"new":[75,95,136,167,199],"drug":[76],"increasingly":[78],"more":[79,151,160],"expensive":[80],"in":[81,89],"spite":[82],"massive":[85],"use":[86],"informatics":[88],"Medicinal":[90],"Chemistry.":[91],"CRISPR":[92],"technology":[93],"adds":[94],"alternatives":[96],"cure":[98],"by":[100,126,172,216],"removing":[101],"defects":[103],"responsible":[104],"genome-related":[106],"pathologies.":[107],"In":[108,132,165],"principle,":[109],"same":[111],"technology,":[112],"however,":[113],"could":[114],"also":[115,187],"be":[116],"exploited":[117],"induce":[119],"protein":[120],"mutations":[121],"whose":[122],"controlled":[125],"presence":[128],"suitable":[130,161],"ligands.":[131],"this":[133],"paper,":[134],"idea":[137],"proposed":[139],"realization":[142],"mutated":[144],"proteins,":[145],"on":[146],"surface":[148],"spacious":[152],"transient":[153],"pockets":[154],"formed":[156],"and,":[157],"therefore,":[158],"hosting":[163],"drugs.":[164],"particular,":[166],"allosteric":[168],"sites":[169,214],"obtained":[171],"replacing":[173],"amino-acids":[174],"with":[175,179],"bulky":[176],"side":[177],"chains":[178],"glycine,":[180],"Gly,":[181],"smallest":[183],"amino-acid.":[185],"We":[186],"present":[188],"machine":[190],"learning":[191],"approach":[192],"evaluate":[194],"druggability":[196],"score":[197],"(or":[200],"enlarged)":[201],"pockets.":[202],"Preliminary":[203],"experimental":[204],"results":[205],"very":[207],"promising,":[208],"showing":[209],"10%":[211],"created":[215],"Gly-pipe":[218],"software":[219],"druggable.":[221]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}
