{"id":"https://openalex.org/W2944095172","doi":"https://doi.org/10.1142/s0219720019500203","title":"Inferring disease and pathway associations of long non-coding RNAs using heterogeneous information network model","display_name":"Inferring disease and pathway associations of long non-coding RNAs using heterogeneous information network model","publication_year":2019,"publication_date":"2019-05-10","ids":{"openalex":"https://openalex.org/W2944095172","doi":"https://doi.org/10.1142/s0219720019500203","mag":"2944095172","pmid":"https://pubmed.ncbi.nlm.nih.gov/31617466"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720019500203","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720019500203","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047124747","display_name":"P.V. Sunil Kumar","orcid":"https://orcid.org/0000-0002-1781-8277"},"institutions":[{"id":"https://openalex.org/I114845381","display_name":"National Institute of Technology Calicut","ror":"https://ror.org/03yyd7552","country_code":"IN","type":"education","lineage":["https://openalex.org/I114845381"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"P.\u00a0V. Sunil Kumar","raw_affiliation_strings":["Department of Computer Science and Engineering, National Institute of Technology Calicut, Kozhikkode, Kerala 673601, India"],"raw_orcid":"https://orcid.org/0000-0002-1781-8277","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, National Institute of Technology Calicut, Kozhikkode, Kerala 673601, India","institution_ids":["https://openalex.org/I114845381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066840642","display_name":"G. Gopakumar","orcid":null},"institutions":[{"id":"https://openalex.org/I114845381","display_name":"National Institute of Technology Calicut","ror":"https://ror.org/03yyd7552","country_code":"IN","type":"education","lineage":["https://openalex.org/I114845381"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G. Gopakumar","raw_affiliation_strings":["Department of Computer Science and Engineering, National Institute of Technology Calicut, Kozhikkode, Kerala 673601, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, National Institute of Technology Calicut, Kozhikkode, Kerala 673601, India","institution_ids":["https://openalex.org/I114845381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047124747"],"corresponding_institution_ids":["https://openalex.org/I114845381"],"apc_list":null,"apc_paid":null,"fwci":0.0764,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40386625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"04","first_page":"1950020","last_page":"1950020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9724000096321106,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malat1","display_name":"MALAT1","score":0.7190248370170593},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6732044219970703},{"id":"https://openalex.org/keywords/hotair","display_name":"HOTAIR","score":0.6488156318664551},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49739840626716614},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4561578035354614},{"id":"https://openalex.org/keywords/coding","display_name":"Coding (social sciences)","score":0.42157182097435},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"Long non-coding RNA","score":0.4203762710094452},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.41511255502700806},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.414998859167099},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40409308671951294},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3411005139350891},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2506515681743622},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.16269457340240479},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12581056356430054},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1116509735584259},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09607073664665222},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08312880992889404}],"concepts":[{"id":"https://openalex.org/C2779134362","wikidata":"https://www.wikidata.org/wiki/Q18056223","display_name":"MALAT1","level":5,"score":0.7190248370170593},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6732044219970703},{"id":"https://openalex.org/C2781128886","wikidata":"https://www.wikidata.org/wiki/Q18062498","display_name":"HOTAIR","level":5,"score":0.6488156318664551},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49739840626716614},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4561578035354614},{"id":"https://openalex.org/C179518139","wikidata":"https://www.wikidata.org/wiki/Q5140297","display_name":"Coding (social sciences)","level":2,"score":0.42157182097435},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.4203762710094452},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.41511255502700806},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.414998859167099},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40409308671951294},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3411005139350891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2506515681743622},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16269457340240479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12581056356430054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1116509735584259},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09607073664665222},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08312880992889404},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720019500203","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720019500203","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:31617466","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31617466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W611910056","https://openalex.org/W1831050183","https://openalex.org/W1975563293","https://openalex.org/W1977657574","https://openalex.org/W1981711832","https://openalex.org/W1983335031","https://openalex.org/W2002185065","https://openalex.org/W2044340941","https://openalex.org/W2055157797","https://openalex.org/W2086643053","https://openalex.org/W2113868616","https://openalex.org/W2122617297","https://openalex.org/W2128983843","https://openalex.org/W2140099276","https://openalex.org/W2152970345","https://openalex.org/W2159092541","https://openalex.org/W2159482845","https://openalex.org/W2174181728","https://openalex.org/W2345356016","https://openalex.org/W2408796111","https://openalex.org/W2437043110","https://openalex.org/W2510516621","https://openalex.org/W2512308096","https://openalex.org/W2537679995","https://openalex.org/W2562438098","https://openalex.org/W2571471366","https://openalex.org/W2600010636","https://openalex.org/W2604844899","https://openalex.org/W2606172339","https://openalex.org/W2606766181","https://openalex.org/W2611747160","https://openalex.org/W2744066849","https://openalex.org/W2757497299","https://openalex.org/W2760285987","https://openalex.org/W2782571367","https://openalex.org/W2796861734","https://openalex.org/W2799620190","https://openalex.org/W2799709858","https://openalex.org/W2802616725","https://openalex.org/W2802676107","https://openalex.org/W2803944601","https://openalex.org/W2963919031","https://openalex.org/W3107817112","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W3177597305","https://openalex.org/W2907010999","https://openalex.org/W4200084850","https://openalex.org/W2961085424","https://openalex.org/W3182691860","https://openalex.org/W3121725470","https://openalex.org/W2142344706","https://openalex.org/W2052852368","https://openalex.org/W4286257137","https://openalex.org/W1976149758"],"abstract_inverted_index":{"Recent":[0],"findings":[1],"from":[2,66,73],"biological":[3,141],"experiments":[4],"demonstrate":[5],"that":[6,41,166],"long":[7],"non-coding":[8],"RNAs":[9],"(lncRNAs)":[10],"are":[11,19,105,119],"actively":[12],"involved":[13],"in":[14,101,136,193],"critical":[15],"cellular":[16],"processes":[17],"and":[18,52,86,112,157,200],"associated":[20,173],"with":[21,134,174],"innumerable":[22],"diseases.":[23,53],"Computational":[24],"prediction":[25],"of":[26,50,77,92,114,150],"lncRNA-disease":[27,43,117],"association":[28],"draws":[29],"tremendous":[30],"research":[31],"attention":[32],"nowadays.":[33],"This":[34,124],"paper":[35,125],"proposes":[36,127],"a":[37,67],"machine":[38],"learning":[39],"model":[40,79,205],"predicts":[42],"associations":[44,118,149],"using":[45,61,82,108],"Heterogeneous":[46],"Information":[47],"Network":[48],"(HIN)":[49],"lncRNAs":[51,133,153,189],"A":[54,143],"Support":[55],"Vector":[56],"Machine":[57],"classifier":[58],"is":[59,80,95,172,183,207],"developed":[60],"the":[62,74,78,98,102,109,115,147,169,195,204],"feature":[63],"set":[64],"extracted":[65],"meta-path-based":[68],"parameter,":[69],"Association":[70],"Index":[71],"derived":[72],"HIN.":[75],"Performance":[76],"validated":[81,107],"standard":[83],"statistical":[84],"metrics":[85],"it":[87],"generated":[88],"an":[89,128],"AUC":[90],"value":[91],"0.87,":[93],"which":[94,137],"better":[96],"than":[97,176],"existing":[99],"methods":[100],"literature.":[103],"Results":[104],"further":[106],"recent":[110],"literature":[111],"many":[113,167],"predicted":[116],"identified":[120],"as":[121],"actually":[122],"existing.":[123],"also":[126],"HIN-based":[129],"methodology":[130],"to":[131,185],"associate":[132],"pathways":[135],"they":[138],"may":[139],"have":[140,190],"influence.":[142],"case":[144],"study":[145],"on":[146],"pathway":[148,196],"four":[151],"well-known":[152],"(HOTAIR,":[154],"TUG1,":[155],"NEAT1,":[156],"MALAT1)":[158],"has":[159,163],"been":[160,164],"conducted.":[161],"It":[162],"observed":[165],"times":[168],"same":[170],"lncRNA":[171],"more":[175],"one":[177],"biologically":[178],"related":[179],"pathways.":[180],"Further":[181],"exploration":[182],"needed":[184],"substantiate":[186],"whether":[187],"such":[188],"any":[191],"role":[192],"determining":[194],"interplay.":[197],"The":[198],"script":[199],"sample":[201],"data":[202],"for":[203],"construction":[206],"freely":[208],"available":[209],"at":[210],"http://bdbl.nitc.ac.in/LncDisPath/index.html.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-05T06:14:27.290980","created_date":"2025-10-10T00:00:00"}