{"id":"https://openalex.org/W2914812568","doi":"https://doi.org/10.1142/s0219720019500094","title":"Noise model estimation with application to gene expression","display_name":"Noise model estimation with application to gene expression","publication_year":2019,"publication_date":"2019-01-25","ids":{"openalex":"https://openalex.org/W2914812568","doi":"https://doi.org/10.1142/s0219720019500094","mag":"2914812568","pmid":"https://pubmed.ncbi.nlm.nih.gov/31057070"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720019500094","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720019500094","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012334256","display_name":"Polina Zhornikova","orcid":null},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Polina Zhornikova","raw_affiliation_strings":["Faculty of Mathematics and Mechanics, St. Petersburg State University, Universitetskaya Nab. 7/9, 199034 St. Petersburg, Russia"],"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics and Mechanics, St. Petersburg State University, Universitetskaya Nab. 7/9, 199034 St. Petersburg, Russia","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036930517","display_name":"Nina Golyandina","orcid":"https://orcid.org/0000-0003-1400-8209"},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Nina Golyandina","raw_affiliation_strings":["Faculty of Mathematics and Mechanics, St. Petersburg State University, Universitetskaya Nab. 7/9, 199034 St. Petersburg, Russia"],"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics and Mechanics, St. Petersburg State University, Universitetskaya Nab. 7/9, 199034 St. Petersburg, Russia","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002399513","display_name":"Alexander V. Spirov","orcid":"https://orcid.org/0000-0002-0509-6203"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Spirov","raw_affiliation_strings":["The Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, Torez Pr. 44, 194223 St. Petersburg, Russia"],"affiliations":[{"raw_affiliation_string":"The Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, Torez Pr. 44, 194223 St. Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036930517"],"corresponding_institution_ids":["https://openalex.org/I172901346"],"apc_list":null,"apc_paid":null,"fwci":0.3326,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56134651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"17","issue":"02","first_page":"1950009","last_page":"1950009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.6666858196258545},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.5110701322555542},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5091478228569031},{"id":"https://openalex.org/keywords/multiplicative-noise","display_name":"Multiplicative noise","score":0.4700162708759308},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4647485613822937},{"id":"https://openalex.org/keywords/multiplicative-function","display_name":"Multiplicative function","score":0.4638262987136841},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3988867998123169},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3942931890487671},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2860722541809082},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.08241045475006104}],"concepts":[{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.6666858196258545},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5110701322555542},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5091478228569031},{"id":"https://openalex.org/C18015164","wikidata":"https://www.wikidata.org/wiki/Q6935000","display_name":"Multiplicative noise","level":5,"score":0.4700162708759308},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4647485613822937},{"id":"https://openalex.org/C42747912","wikidata":"https://www.wikidata.org/wiki/Q1048447","display_name":"Multiplicative function","level":2,"score":0.4638262987136841},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3988867998123169},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3942931890487671},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2860722541809082},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.08241045475006104},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.0},{"id":"https://openalex.org/C84462506","wikidata":"https://www.wikidata.org/wiki/Q173142","display_name":"Digital signal processing","level":2,"score":0.0},{"id":"https://openalex.org/C131021393","wikidata":"https://www.wikidata.org/wiki/Q7512759","display_name":"Signal transfer function","level":4,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C13412647","wikidata":"https://www.wikidata.org/wiki/Q174948","display_name":"Analog signal","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001756","descriptor_name":"Blastoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001756","descriptor_name":"Blastoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001756","descriptor_name":"Blastoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720019500094","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720019500094","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:31057070","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31057070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/10"},{"display_name":"Peace, Justice and strong institutions","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G7022156211","display_name":null,"funder_award_id":"16-04-00821","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W301018780","https://openalex.org/W1954978139","https://openalex.org/W1980804701","https://openalex.org/W1990127492","https://openalex.org/W1991878356","https://openalex.org/W2006568647","https://openalex.org/W2073881036","https://openalex.org/W2078723335","https://openalex.org/W2088723672","https://openalex.org/W2092185780","https://openalex.org/W2103354991","https://openalex.org/W2114870653","https://openalex.org/W2119883478","https://openalex.org/W2135105208","https://openalex.org/W2137057693","https://openalex.org/W2140286963","https://openalex.org/W2143368326","https://openalex.org/W2329556022","https://openalex.org/W2339862102","https://openalex.org/W2463778280","https://openalex.org/W2791801039","https://openalex.org/W2797319337","https://openalex.org/W2808220546","https://openalex.org/W3102998043","https://openalex.org/W4232129301"],"related_works":["https://openalex.org/W4318195686","https://openalex.org/W2975999359","https://openalex.org/W4287173569","https://openalex.org/W2100121758","https://openalex.org/W3022718941","https://openalex.org/W4287812451","https://openalex.org/W1996414039","https://openalex.org/W2506602630","https://openalex.org/W3097284316","https://openalex.org/W2332961228"],"abstract_inverted_index":{"Algorithms":[0],"for":[1,22,47,73,88,119],"the":[2,8,32,39,57,66,74,89,101,106,112],"estimation":[3],"of":[4,10,49,105],"noise":[5,11,59],"level":[6],"and":[7,31,68,76,82,114,121],"detection":[9],"model":[12],"are":[13,16,36,86,94,109],"proposed.":[14],"They":[15],"applied":[17],"to":[18,55,63,100],"gene":[19,29],"expression":[20,30],"data":[21,27,41,98],"<i>Drosophila</i>":[23],"embryos.":[24],"The":[25,92],"2D":[26,77,84,115],"on":[28,96],"extracted":[33],"1D":[34,40,75,113],"profiles":[35],"considered.":[37],"Since":[38],"contain":[42],"processing":[43,51],"errors,":[44],"an":[45],"algorithm":[46],"separation":[48],"these":[50],"errors":[52],"is":[53,71,117],"constructed":[54],"estimate":[56],"biological":[58],"level.":[60],"An":[61],"approach":[62],"discrimination":[64],"between":[65],"additive":[67],"multiplicative":[69],"models":[70],"suggested":[72],"cases.":[78],"Singular":[79],"spectrum":[80],"analysis":[81],"its":[83],"extension":[85],"exploited":[87],"pattern":[90],"extraction.":[91],"algorithms":[93],"tested":[95],"artificial":[97],"similar":[99],"real":[102],"data.":[103],"Comparison":[104],"results,":[107],"which":[108],"obtained":[110],"by":[111],"methods,":[116],"performed":[118],"<i>Kr\u00fcppel</i>":[120],"<i>giant</i>":[122],"genes.":[123]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}