{"id":"https://openalex.org/W2899065368","doi":"https://doi.org/10.1142/s021972001950001x","title":"Integrating network topology, gene expression data and GO annotation information for protein complex prediction","display_name":"Integrating network topology, gene expression data and GO annotation information for protein complex prediction","publication_year":2018,"publication_date":"2018-10-31","ids":{"openalex":"https://openalex.org/W2899065368","doi":"https://doi.org/10.1142/s021972001950001x","mag":"2899065368","pmid":"https://pubmed.ncbi.nlm.nih.gov/30803297"},"language":"en","primary_location":{"id":"doi:10.1142/s021972001950001x","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s021972001950001x","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100441789","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0003-3605-9373"},"institutions":[{"id":"https://openalex.org/I13985625","display_name":"East China Jiaotong University","ror":"https://ror.org/05x2f1m38","country_code":"CN","type":"education","lineage":["https://openalex.org/I13985625"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["School of Science, East China Jiaotong University, Nanchang 330013, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Science, East China Jiaotong University, Nanchang 330013, P. R. China","institution_ids":["https://openalex.org/I13985625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069988397","display_name":"Jia Xu","orcid":"https://orcid.org/0000-0003-0254-6261"},"institutions":[{"id":"https://openalex.org/I13985625","display_name":"East China Jiaotong University","ror":"https://ror.org/05x2f1m38","country_code":"CN","type":"education","lineage":["https://openalex.org/I13985625"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Xu","raw_affiliation_strings":["School of Mechatronic Engineering, East China Jiaotong University, Nanchang 330013, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mechatronic Engineering, East China Jiaotong University, Nanchang 330013, P. R. China","institution_ids":["https://openalex.org/I13985625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011390157","display_name":"Yuanyuan Li","orcid":"https://orcid.org/0000-0003-2981-8976"},"institutions":[{"id":"https://openalex.org/I91125648","display_name":"Wuhan Institute of Technology","ror":"https://ror.org/04jcykh16","country_code":"CN","type":"education","lineage":["https://openalex.org/I91125648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Li","raw_affiliation_strings":["School of Mathematics and Statistics, Wuhan Institute of Technology in Wuhan, Wuhan 430072, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Wuhan Institute of Technology in Wuhan, Wuhan 430072, P. R. China","institution_ids":["https://openalex.org/I91125648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009409122","display_name":"Xiufen Zou","orcid":"https://orcid.org/0000-0001-5294-0764"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiufen Zou","raw_affiliation_strings":["School of Mathematics and Statistics, Wuhan University, Wuhan 430072, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Wuhan University, Wuhan 430072, P. R. China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100441789"],"corresponding_institution_ids":["https://openalex.org/I13985625"],"apc_list":null,"apc_paid":null,"fwci":0.7447,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71147566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"17","issue":"01","first_page":"1950001","last_page":"1950001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6348657011985779},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6288595795631409},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.568329930305481},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.5671009421348572},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.5518550872802734},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5441017150878906},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5352581143379211},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.5017309188842773},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.48308756947517395},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.45840388536453247},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.42116281390190125},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4183664321899414},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3786960244178772},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3510112166404724},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3199024796485901},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2837296724319458},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16746476292610168},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.1241174042224884},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11811986565589905},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.09884339570999146}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6348657011985779},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6288595795631409},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.568329930305481},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.5671009421348572},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.5518550872802734},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5441017150878906},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5352581143379211},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.5017309188842773},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.48308756947517395},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.45840388536453247},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.42116281390190125},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4183664321899414},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3786960244178772},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3510112166404724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3199024796485901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2837296724319458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16746476292610168},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.1241174042224884},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11811986565589905},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.09884339570999146},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s021972001950001x","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s021972001950001x","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:30803297","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30803297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1302938317","display_name":null,"funder_award_id":"11831015","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G346703757","display_name":null,"funder_award_id":"11626102","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7519231844","display_name":null,"funder_award_id":"61802125","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8756903799","display_name":null,"funder_award_id":"20181BAB202006","funder_id":"https://openalex.org/F4320326696","funder_display_name":"Jiangxi Provincial Department of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326696","display_name":"Jiangxi Provincial Department of Science and Technology","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W796286943","https://openalex.org/W1575542444","https://openalex.org/W1783384641","https://openalex.org/W1876024155","https://openalex.org/W1934405236","https://openalex.org/W1968842724","https://openalex.org/W1973508741","https://openalex.org/W1977186059","https://openalex.org/W1982732700","https://openalex.org/W1985817649","https://openalex.org/W1986214964","https://openalex.org/W2007448777","https://openalex.org/W2036799174","https://openalex.org/W2039441578","https://openalex.org/W2062451863","https://openalex.org/W2065304353","https://openalex.org/W2082565035","https://openalex.org/W2084619201","https://openalex.org/W2100371004","https://openalex.org/W2103460693","https://openalex.org/W2107067224","https://openalex.org/W2117691146","https://openalex.org/W2119359534","https://openalex.org/W2121507105","https://openalex.org/W2124777133","https://openalex.org/W2128049108","https://openalex.org/W2134019300","https://openalex.org/W2136850043","https://openalex.org/W2140280811","https://openalex.org/W2152486860","https://openalex.org/W2152495216","https://openalex.org/W2163487866","https://openalex.org/W2166043581","https://openalex.org/W2167869241","https://openalex.org/W2191274703","https://openalex.org/W2281778589","https://openalex.org/W2299896090","https://openalex.org/W2330042283","https://openalex.org/W2340083000","https://openalex.org/W2371140222","https://openalex.org/W2439325218","https://openalex.org/W2478699542","https://openalex.org/W2527742284","https://openalex.org/W2531496612","https://openalex.org/W2613827585","https://openalex.org/W3098674174"],"related_works":["https://openalex.org/W2800059693","https://openalex.org/W37860747","https://openalex.org/W2066232588","https://openalex.org/W4377086792","https://openalex.org/W2087473883","https://openalex.org/W2099913238","https://openalex.org/W2767490506","https://openalex.org/W2131407941","https://openalex.org/W2586268529","https://openalex.org/W2125650596"],"abstract_inverted_index":{"The":[0,152],"prediction":[1],"of":[2,18,32,68,72,84,97,131,143,169],"protein":[3,8,39,75,121,178],"complexes":[4,40,122,179],"based":[5,41,100],"on":[6,42,101,139,167],"the":[7,16,24,52,73,82,85,109,124,129,132,137,157,164,170],"interaction":[9,44],"network":[10],"is":[11,173],"a":[12,65,93,160],"fundamental":[13],"task":[14],"for":[15],"understanding":[17],"cellular":[19],"life":[20],"as":[21,23],"well":[22],"mechanisms":[25],"underlying":[26],"complex":[27,76],"disease.":[28],"A":[29],"great":[30],"number":[31,67],"methods":[33,78,166],"have":[34,181],"been":[35,183],"developed":[36],"to":[37,81,119,175],"predict":[38,120],"protein-protein":[43],"(PPI)":[45],"networks":[46,142],"in":[47],"recent":[48],"years.":[49],"However,":[50],"because":[51],"high":[53],"throughput":[54],"data":[55],"obtained":[56],"from":[57,123],"experimental":[58],"biotechnology":[59],"are":[60,79],"incomplete,":[61],"and":[62,114,145,172],"usually":[63],"contain":[64],"large":[66],"spurious":[69],"interactions,":[70],"most":[71,168],"network-based":[74],"identification":[77],"sensitive":[80],"reliability":[83],"PPI":[86,141],"network.":[87],"In":[88],"this":[89],"paper,":[90],"we":[91,135],"propose":[92],"new":[94],"method,":[95,134],"Identification":[96],"Protein":[98,103],"Complex":[99],"Refined":[102],"Interaction":[104],"Network":[105],"(IPC-RPIN),":[106],"which":[107,180],"integrates":[108],"topology,":[110],"gene":[111],"expression":[112],"profiles":[113],"GO":[115],"functional":[116],"annotation":[117],"information":[118],"reconstructed":[125],"networks.":[126],"To":[127],"demonstrate":[128],"performance":[130],"IPC-RPIN":[133,138,158],"evaluated":[136],"three":[140],"Saccharomycescerevisiae":[144],"compared":[146],"it":[147],"with":[148],"four":[149],"state-of-the-art":[150],"methods.":[151],"simulation":[153],"results":[154],"show":[155],"that":[156],"achieved":[159],"better":[161],"result":[162],"than":[163],"other":[165],"measurements":[171],"able":[174],"discover":[176],"small":[177],"traditionally":[182],"neglected.":[184]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}