{"id":"https://openalex.org/W2805863023","doi":"https://doi.org/10.1142/s0219720018500166","title":"Computational prediction of antifungal peptides via Chou\u2019s PseAAC and SVM","display_name":"Computational prediction of antifungal peptides via Chou\u2019s PseAAC and SVM","publication_year":2018,"publication_date":"2018-05-30","ids":{"openalex":"https://openalex.org/W2805863023","doi":"https://doi.org/10.1142/s0219720018500166","mag":"2805863023","pmid":"https://pubmed.ncbi.nlm.nih.gov/30105927"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720018500166","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720018500166","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049958376","display_name":"Maryam Mousavizadegan","orcid":null},"institutions":[{"id":"https://openalex.org/I39268498","display_name":"University of Isfahan","ror":"https://ror.org/05h9t7759","country_code":"IR","type":"education","lineage":["https://openalex.org/I39268498"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maryam Mousavizadegan","raw_affiliation_strings":["Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran","institution_ids":["https://openalex.org/I39268498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082430755","display_name":"Hassan Mohabatkar","orcid":"https://orcid.org/0000-0002-5151-3768"},"institutions":[{"id":"https://openalex.org/I39268498","display_name":"University of Isfahan","ror":"https://ror.org/05h9t7759","country_code":"IR","type":"education","lineage":["https://openalex.org/I39268498"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Hassan Mohabatkar","raw_affiliation_strings":["Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran","institution_ids":["https://openalex.org/I39268498"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082430755"],"corresponding_institution_ids":["https://openalex.org/I39268498"],"apc_list":null,"apc_paid":null,"fwci":4.9421,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95959027,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"16","issue":"04","first_page":"1850016","last_page":"1850016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifungal","display_name":"Antifungal","score":0.8345198035240173},{"id":"https://openalex.org/keywords/pseudo-amino-acid-composition","display_name":"Pseudo amino acid composition","score":0.6233463883399963},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.6181849837303162},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.6160688996315002},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.5050840973854065},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4529000520706177},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4166552424430847},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4005427956581116},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35158324241638184},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2287711203098297},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20385733246803284},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.12234950065612793}],"concepts":[{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.8345198035240173},{"id":"https://openalex.org/C2780362125","wikidata":"https://www.wikidata.org/wiki/Q7254464","display_name":"Pseudo amino acid composition","level":4,"score":0.6233463883399963},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.6181849837303162},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.6160688996315002},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5050840973854065},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4529000520706177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4166552424430847},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4005427956581116},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35158324241638184},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2287711203098297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20385733246803284},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.12234950065612793},{"id":"https://openalex.org/C2779138802","wikidata":"https://www.wikidata.org/wiki/Q418602","display_name":"Dipeptide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720018500166","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720018500166","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:30105927","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30105927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4399999976158142}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324152","display_name":"University of Isfahan","ror":"https://ror.org/05h9t7759"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W13034104","https://openalex.org/W278909723","https://openalex.org/W615254675","https://openalex.org/W1514738334","https://openalex.org/W1542652324","https://openalex.org/W1835114223","https://openalex.org/W1977241485","https://openalex.org/W1978444624","https://openalex.org/W1980256262","https://openalex.org/W1981091069","https://openalex.org/W1989751871","https://openalex.org/W1992450378","https://openalex.org/W1997996819","https://openalex.org/W2003613304","https://openalex.org/W2003897459","https://openalex.org/W2008056655","https://openalex.org/W2017337590","https://openalex.org/W2023036152","https://openalex.org/W2035167810","https://openalex.org/W2038681300","https://openalex.org/W2046691535","https://openalex.org/W2060846993","https://openalex.org/W2070762622","https://openalex.org/W2074196504","https://openalex.org/W2093226264","https://openalex.org/W2094210743","https://openalex.org/W2097606916","https://openalex.org/W2097936772","https://openalex.org/W2102794349","https://openalex.org/W2107432340","https://openalex.org/W2119387367","https://openalex.org/W2122181892","https://openalex.org/W2128084817","https://openalex.org/W2131192673","https://openalex.org/W2145957695","https://openalex.org/W2149168973","https://openalex.org/W2149730127","https://openalex.org/W2160780417","https://openalex.org/W2312508087","https://openalex.org/W2896865833","https://openalex.org/W2917073363","https://openalex.org/W2967636285","https://openalex.org/W3144619878","https://openalex.org/W4239510810","https://openalex.org/W4252471754","https://openalex.org/W4312960235"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4224009465","https://openalex.org/W4286629047","https://openalex.org/W3195168932","https://openalex.org/W1996541855","https://openalex.org/W3200179079","https://openalex.org/W2556319748","https://openalex.org/W2312508087","https://openalex.org/W2042112205"],"abstract_inverted_index":{"With":[0],"the":[1,7,23,38,47,80,94,109,118,127,131,139,160,165,171],"increase":[2],"in":[3,6,19,41,121,175,192],"immunocompromised":[4],"patients":[5],"recent":[8],"years,":[9],"fungal":[10],"infections":[11],"have":[12,51,64],"emerged":[13],"as":[14],"new":[15,43],"and":[16,22,101,120,162,190,195],"serious":[17],"threat":[18],"hospitals.":[20],"This,":[21],"insufficiency":[24],"of":[25,58,88,93,108,153,164,183,197],"current":[26],"antifungal":[27,44,59,89,184],"therapies":[28],"alongside":[29],"their":[30],"toxic":[31],"effects":[32],"on":[33,126],"patients,":[34],"has":[35],"led":[36],"to":[37,72,148],"increased":[39],"interest":[40],"seeking":[42],"peptides.":[45,60,90,199],"In":[46,155],"present":[48],"study,":[49],"we":[50,63],"developed":[52],"a":[53],"prediction":[54,133,182],"method":[55,145],"for":[56,85,181],"screening":[57,194],"For":[61,105],"this,":[62],"chosen":[65],"Chou\u2019s":[66],"pseudo":[67],"amino":[68],"acid":[69],"composition":[70],"(PseAAC)":[71],"translate":[73],"peptide":[74],"sequences":[75],"into":[76],"numeric":[77],"values.":[78],"Thus,":[79],"SVM":[81,144],"classifier":[82,95,119],"was":[83,96],"performed":[84,125],"binomial":[86],"classification":[87],"The":[91,135,167],"performance":[92],"evaluated":[97],"via":[98],"ten-fold":[99],"cross-validation":[100],"an":[102],"independent":[103],"dataset.":[104],"further":[106],"validation":[107],"model":[110],"developed,":[111],"22":[112],"P24-derived":[113],"peptides":[114,129],"were":[115,124],"predicted":[116],"using":[117],"vitro":[122,156],"assays":[123],"three":[128],"with":[130,151],"highest":[132],"score.":[134],"results":[136,157,168],"showed":[137],"that":[138,170],"PseAAC":[140],"[Formula:":[141],"see":[142],"text]":[143],"is":[146,178],"able":[147],"predict":[149],"AFPs":[150],"ACC":[152],"94.76%.":[154],"also":[158],"validate":[159],"SEN":[161],"SPC":[163],"classifier.":[166],"suggest":[169],"computational":[172],"approach":[173],"used":[174],"this":[176],"study":[177],"highly":[179],"efficient":[180],"peptides,":[185],"which":[186],"can":[187],"save":[188],"time":[189],"money":[191],"AFP":[193],"synthesis":[196],"novel":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}