{"id":"https://openalex.org/W2773538142","doi":"https://doi.org/10.1142/s0219720017500275","title":"Kernel differential subgraph reveals dynamic changes in biomolecular networks","display_name":"Kernel differential subgraph reveals dynamic changes in biomolecular networks","publication_year":2017,"publication_date":"2017-12-05","ids":{"openalex":"https://openalex.org/W2773538142","doi":"https://doi.org/10.1142/s0219720017500275","mag":"2773538142","pmid":"https://pubmed.ncbi.nlm.nih.gov/29281952"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720017500275","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219720017500275","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219720017500275","source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219720017500275","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100677765","display_name":"Jiang Xie","orcid":"https://orcid.org/0000-0001-9944-8822"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiang Xie","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-9944-8822","affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058213415","display_name":"Dongfang Lu","orcid":"https://orcid.org/0009-0008-1499-2262"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongfang Lu","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343407","display_name":"Jiaxin Li","orcid":"https://orcid.org/0000-0002-1681-3271"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxin Li","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444938","display_name":"Jiao Wang","orcid":"https://orcid.org/0000-0001-9875-5425"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiao Wang","raw_affiliation_strings":["Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102742215","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0003-1868-727X"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["Pulmonary Department, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Department, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, P. R. China","institution_ids":["https://openalex.org/I4210127074","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360600","display_name":"Yanhui Li","orcid":"https://orcid.org/0000-0002-5700-3953"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhui Li","raw_affiliation_strings":["Pulmonary Department, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Department, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, P. R. China","institution_ids":["https://openalex.org/I4210127074","https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076311980","display_name":"Qing Nie","orcid":"https://orcid.org/0000-0002-8804-3368"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Nie","raw_affiliation_strings":["Department of Mathematics, University of California, Irvine, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of California, Irvine, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5058213415","https://openalex.org/A5100444938","https://openalex.org/A5100677765"],"corresponding_institution_ids":["https://openalex.org/I113940042"],"apc_list":null,"apc_paid":null,"fwci":0.2243,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57775117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"16","issue":"01","first_page":"1750027","last_page":"1750027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.7059537172317505},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.6759541034698486},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5455602407455444},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4903092682361603},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4876607656478882},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.4672541320323944},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.46520429849624634},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4614025950431824},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4119945168495178},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4019344747066498},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3444490432739258},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3410293459892273},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3296378254890442},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17587882280349731},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09482967853546143}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7059537172317505},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.6759541034698486},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5455602407455444},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4903092682361603},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4876607656478882},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.4672541320323944},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.46520429849624634},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4614025950431824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4119945168495178},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4019344747066498},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3444490432739258},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3410293459892273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3296378254890442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17587882280349731},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09482967853546143},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720017500275","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219720017500275","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219720017500275","source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:29281952","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29281952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":{"id":"doi:10.1142/s0219720017500275","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219720017500275","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219720017500275","source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1882933654","https://openalex.org/W1972937439","https://openalex.org/W1975032412","https://openalex.org/W1979533077","https://openalex.org/W2009717590","https://openalex.org/W2025718369","https://openalex.org/W2035471593","https://openalex.org/W2056353125","https://openalex.org/W2059987067","https://openalex.org/W2060184189","https://openalex.org/W2070923004","https://openalex.org/W2072451938","https://openalex.org/W2082739933","https://openalex.org/W2095833325","https://openalex.org/W2102353246","https://openalex.org/W2103017472","https://openalex.org/W2103067815","https://openalex.org/W2104812688","https://openalex.org/W2106286842","https://openalex.org/W2108156593","https://openalex.org/W2109972881","https://openalex.org/W2112795434","https://openalex.org/W2118423420","https://openalex.org/W2125910575","https://openalex.org/W2129925948","https://openalex.org/W2132960405","https://openalex.org/W2136386001","https://openalex.org/W2137648512","https://openalex.org/W2146414563","https://openalex.org/W2147566730","https://openalex.org/W2148762636","https://openalex.org/W2152401289","https://openalex.org/W2158217645","https://openalex.org/W2158714788","https://openalex.org/W2159482845","https://openalex.org/W2324494114","https://openalex.org/W2414529419","https://openalex.org/W2508551534","https://openalex.org/W2534924637","https://openalex.org/W2604808360","https://openalex.org/W2607363173","https://openalex.org/W4252232449","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2114466827","https://openalex.org/W2135896045","https://openalex.org/W2155261113","https://openalex.org/W2156431842","https://openalex.org/W1584645941","https://openalex.org/W2066447707","https://openalex.org/W2137531873","https://openalex.org/W2043924719","https://openalex.org/W1974083191","https://openalex.org/W2111862142"],"abstract_inverted_index":{"Many":[0],"major":[1],"diseases,":[2],"including":[3],"various":[4],"types":[5],"of":[6,16,29,48,53,73,90,96,138],"cancer,":[7],"are":[8,191,226],"increasingly":[9],"threatening":[10],"human":[11],"health.":[12],"However,":[13],"the":[14,17,26,46,54,71,79,88,94,113,127,130,134,139,143,148,155,160,165,168,199,203,224,229,256],"mechanisms":[15],"dynamic":[18],"processes":[19,230],"underlying":[20],"these":[21],"diseases":[22],"remain":[23],"ambiguous.":[24],"From":[25],"holistic":[27],"perspective":[28,243],"systems":[30],"science,":[31],"complex":[32],"biological":[33,37],"networks":[34,41,77,83,119],"can":[35],"reveal":[36],"phenomena.":[38],"Changes":[39],"among":[40],"in":[42,76,84,123,201,231,244],"different":[43,85,121,144,174],"states":[44,86],"influence":[45],"direction":[47],"living":[49],"organisms.":[50],"The":[51,66],"identification":[52,72],"kernel":[55],"differential":[56,135],"subgraph":[57],"(KDS)":[58],"that":[59,190,223],"leads":[60],"to":[61,70,111,180,195,228,251,258],"drastic":[62],"changes":[63],"is":[64],"critical.":[65],"existing":[67,237],"studies":[68],"contribute":[69],"a":[74,105,241],"KDS":[75,108],"with":[78,120,236],"same":[80,169],"nodes;":[81],"however,":[82],"involve":[87],"disappearance":[89],"some":[91,97],"nodes":[92,122,170],"or":[93],"appearance":[95],"new":[98,106],"nodes.":[99,175],"In":[100,233],"this":[101,124,178],"paper,":[102],"we":[103,186],"propose":[104],"topology-based":[107],"(TKDS)":[109],"method":[110,132,179],"explore":[112],"core":[114],"module":[115],"from":[116],"gene":[117,151,215],"regulatory":[118],"process.":[125],"For":[126,142],"common":[128],"nodes,":[129,145],"TKDS":[131,146,158,239,254],"considers":[133,164],"value":[136],"(D-value)":[137],"topological":[140],"change.":[141],"identifies":[147],"most":[149,192],"similar":[150],"pairs":[152],"and":[153,197,205,214,219,248,264],"computes":[154],"D-value.":[156],"Hence,":[157],"discovers":[159],"essential":[161,227],"KDS,":[162],"which":[163],"relationships":[166],"between":[167],"as":[171,173],"well":[172],"After":[176],"applying":[177],"non-small":[181],"cell":[182],"lung":[183],"cancer":[184,204],"(NSCLC),":[185],"identified":[187],"30":[188],"genes":[189,247,263],"likely":[193],"related":[194,250],"NSCLC":[196],"extracted":[198],"KDSs":[200,225,249],"both":[202],"normal":[206],"states.":[207],"Two":[208],"significance":[209],"functional":[210],"modules":[211],"were":[212],"revealed,":[213],"ontology":[216],"(GO)":[217],"analyses":[218],"literature":[220],"mining":[221],"indicated":[222],"NSCLC.":[232,252],"addition,":[234],"compared":[235],"methods,":[238],"provides":[240],"unique":[242],"identifying":[245],"particular":[246],"Moreover,":[253],"has":[255],"potential":[257],"predict":[259],"other":[260],"critical":[261],"disease-related":[262],"modules.":[265]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}