{"id":"https://openalex.org/W2766210168","doi":"https://doi.org/10.1142/s021972001750024x","title":"Robustness versus evolvability analysis for regulatory feed-forward loops","display_name":"Robustness versus evolvability analysis for regulatory feed-forward loops","publication_year":2017,"publication_date":"2017-11-03","ids":{"openalex":"https://openalex.org/W2766210168","doi":"https://doi.org/10.1142/s021972001750024x","mag":"2766210168"},"language":"en","primary_location":{"id":"doi:10.1142/s021972001750024x","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s021972001750024x","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103258556","display_name":"Debika Choudhury","orcid":"https://orcid.org/0000-0002-3273-3845"},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debika Choudhury","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074819032","display_name":"Amit Agarwal","orcid":"https://orcid.org/0000-0002-3933-5014"},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amit Agarwal","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079026550","display_name":"Supreet Saini","orcid":"https://orcid.org/0000-0001-6838-4619"},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Supreet Saini","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079026550"],"corresponding_institution_ids":["https://openalex.org/I162827531"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13710842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"06","first_page":"1750024","last_page":"1750024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evolvability","display_name":"Evolvability","score":0.9886441230773926},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.850446879863739},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5663207173347473},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5530991554260254},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4351721405982971},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.407807320356369},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.22301709651947021},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18141838908195496},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17176282405853271},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09621256589889526}],"concepts":[{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.9886441230773926},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.850446879863739},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5663207173347473},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5530991554260254},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4351721405982971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.407807320356369},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.22301709651947021},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18141838908195496},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17176282405853271},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09621256589889526},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s021972001750024x","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s021972001750024x","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.41999998688697815}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1554180547","https://openalex.org/W1623155147","https://openalex.org/W1637936532","https://openalex.org/W1965877319","https://openalex.org/W1974771965","https://openalex.org/W1982583288","https://openalex.org/W1994540622","https://openalex.org/W2006413392","https://openalex.org/W2020650555","https://openalex.org/W2028443325","https://openalex.org/W2040177850","https://openalex.org/W2051116946","https://openalex.org/W2062650320","https://openalex.org/W2069614478","https://openalex.org/W2070004581","https://openalex.org/W2078236617","https://openalex.org/W2082383308","https://openalex.org/W2083034544","https://openalex.org/W2104989261","https://openalex.org/W2105557836","https://openalex.org/W2109110326","https://openalex.org/W2114978528","https://openalex.org/W2126487485","https://openalex.org/W2145317354","https://openalex.org/W4241088457"],"related_works":["https://openalex.org/W2105160260","https://openalex.org/W2922935424","https://openalex.org/W2571877704","https://openalex.org/W2122461052","https://openalex.org/W1781524388","https://openalex.org/W2040177850","https://openalex.org/W2129140651","https://openalex.org/W2951554642","https://openalex.org/W1681307731","https://openalex.org/W2077175850"],"abstract_inverted_index":{"From":[0],"the":[1,37,43,55,114,125],"definition,":[2],"it":[3],"appears":[4],"that":[5,92,113,124],"phenotypic":[6],"robustness":[7,46,93,130],"and":[8,47,60,81,94,111,131],"evolvability":[9,95,132],"of":[10,22,70,140],"an":[11,135],"organism":[12],"are":[13,96],"inversely":[14],"related":[15],"to":[16,64,73,76,84,127,147],"each":[17],"other.":[18],"However,":[19],"a":[20,50,62],"number":[21],"studies":[23],"exploring":[24],"this":[25,32,105],"question":[26,35],"have":[27],"found":[28],"conflicting":[29],"evidences":[30],"in":[31,68,99,142],"regard.":[33],"This":[34],"motivated":[36],"current":[38],"work":[39],"where":[40],"we":[41,53],"explore":[42],"relationship":[44],"between":[45],"evolvability.":[48],"As":[49],"model":[51],"system,":[52],"pick":[54],"Feed":[56],"Forward":[57],"Loops":[58],"(FFLs),":[59],"develop":[61],"framework":[63],"characterize":[65],"their":[66,71,82],"performance":[67],"terms":[69],"ability":[72,83,126],"resist":[74],"changes":[75],"steady":[77],"state":[78],"expression":[79],"(robustness),":[80],"evolve":[85],"towards":[86],"novel":[87],"phenotypes":[88],"(evolvability).":[89],"We":[90,103,122],"demonstrate":[91],"positively":[97,128],"correlated":[98],"some":[100],"FFL":[101],"topologies.":[102,150],"compare":[104],"against":[106],"other":[107,148],"small":[108],"regulatory":[109,149],"topologies,":[110],"show":[112],"same":[115],"trend":[116],"does":[117],"not":[118],"hold":[119],"among":[120],"them.":[121],"postulate":[123],"link":[129],"could":[133],"be":[134],"additional":[136],"reason":[137],"for":[138],"over-representation":[139],"FFLs":[141],"living":[143],"organisms,":[144],"as":[145],"compared":[146]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2017-11-10T00:00:00"}