{"id":"https://openalex.org/W2588514822","doi":"https://doi.org/10.1142/s0219720017500068","title":"Effects of low dose ionizing radiation on DNA damage-caused pathways by reverse-phase protein array and Bayesian networks","display_name":"Effects of low dose ionizing radiation on DNA damage-caused pathways by reverse-phase protein array and Bayesian networks","publication_year":2017,"publication_date":"2017-02-17","ids":{"openalex":"https://openalex.org/W2588514822","doi":"https://doi.org/10.1142/s0219720017500068","mag":"2588514822","pmid":"https://pubmed.ncbi.nlm.nih.gov/28440122"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720017500068","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720017500068","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080215015","display_name":"Dongchul Kim","orcid":"https://orcid.org/0000-0002-5659-1394"},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong-Chul Kim","raw_affiliation_strings":["Department of Computer Science, University of Texas \u2014 Rio Grande Valley, Edinburg, TX78539, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Texas \u2014 Rio Grande Valley, Edinburg, TX78539, USA","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058010272","display_name":"Mingon Kang","orcid":"https://orcid.org/0000-0002-9565-9523"},"institutions":[{"id":"https://openalex.org/I172980758","display_name":"Kennesaw State University","ror":"https://ror.org/00jeqjx33","country_code":"US","type":"education","lineage":["https://openalex.org/I172980758"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingon Kang","raw_affiliation_strings":["Department of Computer Science, Kennesaw State University, Marietta, GA 30060, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Kennesaw State University, Marietta, GA 30060, USA","institution_ids":["https://openalex.org/I172980758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074501326","display_name":"Ashis Kumer Biswas","orcid":"https://orcid.org/0000-0002-7446-4639"},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashis Biswas","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Texas at Arlington, Arlington, TX76019, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Texas at Arlington, Arlington, TX76019, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087681217","display_name":"Chin\u2010Rang Yang","orcid":"https://orcid.org/0000-0002-3445-9819"},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart Lung and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin-Rang Yang","raw_affiliation_strings":["Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20814, USA"],"affiliations":[{"raw_affiliation_string":"Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357601","display_name":"Xiaoyu Wang","orcid":"https://orcid.org/0000-0002-4665-5024"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyu Wang","raw_affiliation_strings":["Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX75390, USA"],"affiliations":[{"raw_affiliation_string":"Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015128288","display_name":"Jean Gao","orcid":null},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean X. Gao","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Texas at Arlington, Arlington, TX76019, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Texas at Arlington, Arlington, TX76019, USA","institution_ids":["https://openalex.org/I189196454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015128288"],"corresponding_institution_ids":["https://openalex.org/I189196454"],"apc_list":null,"apc_paid":null,"fwci":0.319,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.56492058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"02","first_page":"1750006","last_page":"1750006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7071653604507446},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5944268703460693},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5466580390930176},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5113794207572937},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5090495944023132},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.45800045132637024},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.43796294927597046},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.435024231672287},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"Ionizing radiation","score":0.41116997599601746},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.362072229385376},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34276315569877625},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.2770242691040039},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14897650480270386},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13242870569229126},{"id":"https://openalex.org/keywords/irradiation","display_name":"Irradiation","score":0.09284400939941406},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08525997400283813}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7071653604507446},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5944268703460693},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5466580390930176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5113794207572937},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5090495944023132},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45800045132637024},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.43796294927597046},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.435024231672287},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.41116997599601746},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.362072229385376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34276315569877625},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2770242691040039},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14897650480270386},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13242870569229126},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.09284400939941406},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08525997400283813},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720017500068","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720017500068","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:28440122","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28440122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1978627461","https://openalex.org/W1984407262","https://openalex.org/W1992452843","https://openalex.org/W2015705446","https://openalex.org/W2022811243","https://openalex.org/W2028171591","https://openalex.org/W2057536311","https://openalex.org/W2057545775","https://openalex.org/W2067751798","https://openalex.org/W2068123273","https://openalex.org/W2070480084","https://openalex.org/W2073414549","https://openalex.org/W2095840394","https://openalex.org/W2105129830","https://openalex.org/W2108622916","https://openalex.org/W2124399788","https://openalex.org/W2129143004","https://openalex.org/W2134977016","https://openalex.org/W2142390772","https://openalex.org/W2145972872","https://openalex.org/W2148782878","https://openalex.org/W2171437346","https://openalex.org/W2597289420","https://openalex.org/W4236354166","https://openalex.org/W4245109505"],"related_works":["https://openalex.org/W2760815521","https://openalex.org/W2033918102","https://openalex.org/W2747101336","https://openalex.org/W1991644354","https://openalex.org/W2004480716","https://openalex.org/W2055890925","https://openalex.org/W1972094156","https://openalex.org/W3125757075","https://openalex.org/W2108718931","https://openalex.org/W2107516157"],"abstract_inverted_index":{"Ionizing":[0],"radiation":[1,54],"(IR)":[2],"causing":[3],"damages":[4],"to":[5,46,51,92,196,199],"Deoxyribonucleic":[6],"acid":[7],"(DNA)":[8],"constitutes":[9],"a":[10,100,151,164,178],"broad":[11],"range":[12],"of":[13,26,42,87,236],"base":[14],"damage":[15,264],"and":[16,20,37,75,85,139,153,167,203,233,238,265,268,278],"double":[17],"strand":[18],"break,":[19],"thereby,":[21],"it":[22],"induces":[23],"the":[24,49,56,61,158,168,174,189,226,240,247],"operation":[25],"relevant":[27],"signaling":[28,62,140,221,271],"pathways":[29,141,202,222,228,272],"such":[30,134,273],"as":[31,135,177,274],"DNA":[32,101,263,279],"repair,":[33],"cell":[34,38,276],"cycle":[35],"control,":[36],"apoptosis.":[39],"The":[40,120,212],"goal":[41],"this":[43,187],"paper":[44],"is":[45,123,148,171],"study":[47],"how":[48,225,239],"exposure":[50],"low":[52,232,258],"dose":[53,259],"affects":[55],"human":[57,77],"body":[58],"by":[59,116,181],"observing":[60],"pathway":[63,121],"associated":[64],"with":[65,109,131,205],"Ataxia":[66,78],"Telangiectasia":[67,79],"mutated":[68],"(ATM)":[69],"using":[70,117,182],"Reverse-Phase":[71],"Protein":[72],"Array":[73],"(RPPA)":[74],"isogenic":[76],"(A-T)":[80],"cells":[81],"under":[82,112,223,231],"different":[83,230],"amounts":[84],"durations":[86],"IR":[88,113,260],"exposure.":[89],"In":[90,186],"order":[91],"verify":[93],"which":[94,216],"proteins":[95,105,217,242],"could":[96,261],"be":[97,193,197],"involved":[98,219],"in":[99,129,173,220,246],"damage-caused":[102],"pathway,":[103],"only":[104],"that":[106,156,257],"highly":[107],"interact":[108],"each":[110,244],"other":[111,245],"are":[114,218,229],"selected":[115,241],"correlation":[118],"coefficient.":[119],"inference":[122],"derived":[124],"from":[125,142],"learning":[126],"Bayesian":[127,146],"networks":[128,147],"combination":[130],"prior":[132,169,179],"knowledge":[133,170],"Protein-Protein":[136],"Interactions":[137],"(PPIs)":[138],"well-known":[143],"databases.":[144],"Learning":[145],"based":[149],"on":[150],"score":[152,165,175],"search":[154],"scheme":[155],"provides":[157],"highest":[159],"scored":[160],"network":[161,191],"structure":[162],"given":[163],"function,":[166],"included":[172],"function":[176],"probability":[180],"Dempster-Shafer":[183],"theory":[184],"(DST).":[185],"way,":[188],"inferred":[190,227,248],"can":[192],"more":[194,209],"likely":[195],"similar":[198],"already":[200],"discovered":[201],"consistent":[204],"confirmed":[206],"PPIs":[207],"for":[208],"reliable":[210],"inference.":[211],"experimental":[213],"results":[214,255],"show":[215],"IR,":[224,237],"high":[234],"doses":[235],"regulate":[243],"pathways.":[249],"As":[250],"our":[251],"main":[252],"contribution,":[253],"overall":[254],"confirm":[256],"cause":[262],"thereby":[266],"induce":[267],"affect":[269],"related":[270],"apoptosis,":[275],"cycle,":[277],"repair.":[280]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}