{"id":"https://openalex.org/W2530702254","doi":"https://doi.org/10.1142/s0219720016500360","title":"Identification of residues of the archaeal RNA-binding Nip7 proteins specific to environmental conditions","display_name":"Identification of residues of the archaeal RNA-binding Nip7 proteins specific to environmental conditions","publication_year":2016,"publication_date":"2016-10-14","ids":{"openalex":"https://openalex.org/W2530702254","doi":"https://doi.org/10.1142/s0219720016500360","mag":"2530702254","pmid":"https://pubmed.ncbi.nlm.nih.gov/27832721"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720016500360","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720016500360","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060415648","display_name":"Kirill E. Medvedev","orcid":"https://orcid.org/0000-0002-7982-4242"},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["RU","US"],"is_corresponding":true,"raw_author_name":"Kirill E. Medvedev","raw_affiliation_strings":["Department of Biophysics, University of Texas Southwestern, Medical Center, Dallas, Texas 75390, USA","Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7982-4242","affiliations":[{"raw_affiliation_string":"Department of Biophysics, University of Texas Southwestern, Medical Center, Dallas, Texas 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038764591","display_name":"\u041d. \u0410. \u041a\u043e\u043b\u0447\u0430\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0001-6800-8787"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikolay A. Kolchanov","raw_affiliation_strings":["Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia","NRC Kurchatov Institute, Akademika Kurchatova pl., 1, Moscow 123182, Russia","Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"NRC Kurchatov Institute, Akademika Kurchatova pl., 1, Moscow 123182, Russia","institution_ids":["https://openalex.org/I2800235667"]},{"raw_affiliation_string":"Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075293015","display_name":"\u0414. \u0410. \u0410\u0444\u043e\u043d\u043d\u0438\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0001-9738-1409"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry A. Afonnikov","raw_affiliation_strings":["Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia","Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060415648"],"corresponding_institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":0.523,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.72440953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"15","issue":"02","first_page":"1650036","last_page":"1650036"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrostatic-pressure","display_name":"Hydrostatic pressure","score":0.740615725517273},{"id":"https://openalex.org/keywords/extreme-environment","display_name":"Extreme environment","score":0.6255010962486267},{"id":"https://openalex.org/keywords/salt-bridge","display_name":"Salt bridge","score":0.5554401874542236},{"id":"https://openalex.org/keywords/archaea","display_name":"Archaea","score":0.5415769815444946},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5276188850402832},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.44649919867515564},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.43521174788475037},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.43197235465049744},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.425689160823822},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4116322994232178},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.315762996673584},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.2850476801395416},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18418040871620178},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.11408108472824097}],"concepts":[{"id":"https://openalex.org/C2910081258","wikidata":"https://www.wikidata.org/wiki/Q177807","display_name":"Hydrostatic pressure","level":2,"score":0.740615725517273},{"id":"https://openalex.org/C93642007","wikidata":"https://www.wikidata.org/wiki/Q5422399","display_name":"Extreme environment","level":3,"score":0.6255010962486267},{"id":"https://openalex.org/C30765947","wikidata":"https://www.wikidata.org/wiki/Q899119","display_name":"Salt bridge","level":4,"score":0.5554401874542236},{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.5415769815444946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5276188850402832},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.44649919867515564},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43521174788475037},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.43197235465049744},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.425689160823822},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4116322994232178},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.315762996673584},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2850476801395416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18418040871620178},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11408108472824097},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720016500360","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720016500360","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:27832721","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27832721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.46000000834465027}],"awards":[{"id":"https://openalex.org/G8783826533","display_name":null,"funder_award_id":"14-24-00123","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W190514905","https://openalex.org/W1517704237","https://openalex.org/W1979651681","https://openalex.org/W1998918010","https://openalex.org/W2004770123","https://openalex.org/W2004801056","https://openalex.org/W2006328577","https://openalex.org/W2009654319","https://openalex.org/W2022016940","https://openalex.org/W2023385944","https://openalex.org/W2029759141","https://openalex.org/W2030416595","https://openalex.org/W2032307826","https://openalex.org/W2033992899","https://openalex.org/W2037399219","https://openalex.org/W2038851726","https://openalex.org/W2052172298","https://openalex.org/W2064604013","https://openalex.org/W2068186398","https://openalex.org/W2072207870","https://openalex.org/W2074670905","https://openalex.org/W2075918185","https://openalex.org/W2092979763","https://openalex.org/W2094874234","https://openalex.org/W2095297536","https://openalex.org/W2100009368","https://openalex.org/W2103048952","https://openalex.org/W2104437034","https://openalex.org/W2104572985","https://openalex.org/W2115786477","https://openalex.org/W2118148390","https://openalex.org/W2130060890","https://openalex.org/W2137631721","https://openalex.org/W2140185986","https://openalex.org/W2141562636","https://openalex.org/W2141627824","https://openalex.org/W2146614049","https://openalex.org/W2148698435","https://openalex.org/W2148912052","https://openalex.org/W2153195964","https://openalex.org/W2154820180","https://openalex.org/W2155733474","https://openalex.org/W2158419708","https://openalex.org/W2158714788","https://openalex.org/W2159826393","https://openalex.org/W2163469698","https://openalex.org/W2167806813","https://openalex.org/W2168340825","https://openalex.org/W2169454843","https://openalex.org/W2171231988","https://openalex.org/W2254215730","https://openalex.org/W2324459447","https://openalex.org/W4238718120"],"related_works":["https://openalex.org/W45778460","https://openalex.org/W2021121470","https://openalex.org/W157779934","https://openalex.org/W3170905732","https://openalex.org/W2760222138","https://openalex.org/W1984962510","https://openalex.org/W3087159754","https://openalex.org/W2031018687","https://openalex.org/W3120204839","https://openalex.org/W4253117410"],"abstract_inverted_index":{"The":[0,67,84],"understanding":[1],"of":[2,9,26,31,44,64,69,92,111,127],"biological":[3],"and":[4,14,28,62,102],"molecular":[5],"mechanisms":[6],"providing":[7],"survival":[8],"cells":[10],"under":[11],"extreme":[12,134],"temperatures":[13],"pressures":[15],"will":[16],"help":[17],"to":[18,23,29,52,58,73,81,89,105],"answer":[19],"fundamental":[20],"questions":[21],"related":[22,72,80],"the":[24,45,59,93,106,125],"origin":[25],"life":[27],"design":[30],"biotechnologically":[32],"important":[33],"enzymes":[34],"with":[35],"new":[36],"properties.":[37],"Here,":[38],"we":[39],"analyze":[40],"amino":[41],"acid":[42],"sequences":[43],"Nip7":[46,94],"proteins":[47],"from":[48],"35":[49],"archaeal":[50],"species":[51],"identify":[53],"positions":[54,71,115],"containing":[55],"mutations":[56],"specific":[57],"hydrostatic":[60],"pressure":[61,74,107],"temperature":[63,82,90],"organism's":[65],"habitat.":[66],"number":[68],"such":[70],"change":[75],"is":[76],"much":[77],"lower":[78],"than":[79,104],"change.":[83],"results":[85],"suggest":[86],"that":[87],"adaptation":[88],"changes":[91],"protein":[95,128],"cause":[96],"more":[97],"pronounced":[98],"modifications":[99],"in":[100,119],"sequence":[101],"structure,":[103],"changes.":[108],"Structural":[109],"analysis":[110],"residues":[112],"at":[113,133],"these":[114],"demonstrated":[116],"their":[117],"involvement":[118],"salt-bridge":[120],"formation,":[121],"which":[122],"may":[123],"reflect":[124],"importance":[126],"structure":[129],"stabilization":[130],"by":[131],"salt-bridges":[132],"environmental":[135],"conditions.":[136]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}