{"id":"https://openalex.org/W2189144374","doi":"https://doi.org/10.1142/s0219720016500050","title":"A method to predict different mechanisms for blood\u2013brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine","display_name":"A method to predict different mechanisms for blood\u2013brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine","publication_year":2015,"publication_date":"2015-10-27","ids":{"openalex":"https://openalex.org/W2189144374","doi":"https://doi.org/10.1142/s0219720016500050","mag":"2189144374","pmid":"https://pubmed.ncbi.nlm.nih.gov/26632324"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720016500050","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720016500050","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112315588","display_name":"Ludi Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ludi Jiang","raw_affiliation_strings":["School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101608201","display_name":"Jia\u2212Hua Chen","orcid":"https://orcid.org/0000-0003-4841-8329"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahua Chen","raw_affiliation_strings":["School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029016985","display_name":"Yusu He","orcid":null},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yusu He","raw_affiliation_strings":["School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621557","display_name":"Yanling Zhang","orcid":"https://orcid.org/0000-0001-6344-8804"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanling Zhang","raw_affiliation_strings":["School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085734930","display_name":"Gongyu Li","orcid":"https://orcid.org/0000-0002-2367-4433"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gongyu Li","raw_affiliation_strings":["School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China","institution_ids":["https://openalex.org/I17747738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100621557"],"corresponding_institution_ids":["https://openalex.org/I17747738"],"apc_list":null,"apc_paid":null,"fwci":1.7356,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.87248086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"01","first_page":"1650005","last_page":"1650005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood\u2013brain-barrier","display_name":"Blood\u2013brain barrier","score":0.639211893081665},{"id":"https://openalex.org/keywords/chinese-herbs","display_name":"Chinese herbs","score":0.6069783568382263},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5969873666763306},{"id":"https://openalex.org/keywords/vector","display_name":"Vector (molecular biology)","score":0.4185892343521118},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3698681592941284},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.36106109619140625},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35259270668029785},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3465229868888855},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.30284351110458374},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.28501445055007935},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"Traditional Chinese medicine","score":0.2468644082546234},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.24056687951087952},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19868913292884827},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1773025393486023}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.639211893081665},{"id":"https://openalex.org/C2909810673","wikidata":"https://www.wikidata.org/wiki/Q261503","display_name":"Chinese herbs","level":4,"score":0.6069783568382263},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5969873666763306},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.4185892343521118},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3698681592941284},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.36106109619140625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35259270668029785},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3465229868888855},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30284351110458374},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.28501445055007935},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.2468644082546234},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24056687951087952},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19868913292884827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1773025393486023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002491","descriptor_name":"Central Nervous System Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002491","descriptor_name":"Central Nervous System Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002491","descriptor_name":"Central Nervous System Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720016500050","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720016500050","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:26632324","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26632324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6399999856948853,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1620810572","https://openalex.org/W1839850369","https://openalex.org/W1912463333","https://openalex.org/W1967063170","https://openalex.org/W1967582909","https://openalex.org/W1973714454","https://openalex.org/W1977274733","https://openalex.org/W1981331152","https://openalex.org/W1985819140","https://openalex.org/W1989387551","https://openalex.org/W1995376525","https://openalex.org/W1996851544","https://openalex.org/W1996950868","https://openalex.org/W1997127038","https://openalex.org/W2003198698","https://openalex.org/W2005334238","https://openalex.org/W2007070530","https://openalex.org/W2016274863","https://openalex.org/W2019702066","https://openalex.org/W2019851851","https://openalex.org/W2021827660","https://openalex.org/W2022872879","https://openalex.org/W2031351528","https://openalex.org/W2035904900","https://openalex.org/W2045871950","https://openalex.org/W2049293086","https://openalex.org/W2056449991","https://openalex.org/W2065831736","https://openalex.org/W2066536516","https://openalex.org/W2067380920","https://openalex.org/W2069147801","https://openalex.org/W2071398410","https://openalex.org/W2074089485","https://openalex.org/W2074407688","https://openalex.org/W2074920600","https://openalex.org/W2082201854","https://openalex.org/W2092238367","https://openalex.org/W2093221398","https://openalex.org/W2101325513","https://openalex.org/W2124258777","https://openalex.org/W2134344823","https://openalex.org/W2160786973","https://openalex.org/W2418213503"],"related_works":["https://openalex.org/W2090763504","https://openalex.org/W148178222","https://openalex.org/W2104657898","https://openalex.org/W1948992892","https://openalex.org/W1886884218","https://openalex.org/W2358690392","https://openalex.org/W2371886129","https://openalex.org/W2379077792","https://openalex.org/W2041461681","https://openalex.org/W3151502406"],"abstract_inverted_index":{"The":[0,127],"blood-brain":[1],"barrier":[2,7],"(BBB),":[3],"a":[4,52],"highly":[5],"selective":[6],"between":[8],"central":[9],"nervous":[10,251],"system":[11,252],"(CNS)":[12],"and":[13,18,54,69,89,118,141,174,199,227,239],"the":[14,20,25,28,33,37,45,66,72,91,100,124,144,147,150,157,183,215,219,231,236,242,255],"blood":[15,26],"stream,":[16],"restricts":[17],"regulates":[19],"penetration":[21],"of":[22,74,93,96,107,159,162,201,218,245],"compounds":[23,88,135,223],"from":[24],"into":[27],"brain.":[29],"Drugs":[30],"that":[31],"affect":[32],"CNS":[34,87,112,139,221,232],"interact":[35],"with":[36,71,192],"BBB":[38,49,94,114,145,160,216],"prior":[39],"to":[40,98,111,133,155,181,213],"their":[41],"target":[42],"site,":[43],"so":[44],"prediction":[46,108],"research":[47,56,101],"on":[48],"permeability":[50,95,161],"is":[51],"fundamental":[53],"significant":[55],"direction":[57],"in":[58,102,123,224,254],"neuropharmacology.":[59],"In":[60],"this":[61,103,228],"study,":[62],"we":[63,79],"combed":[64],"through":[65],"available":[67],"data":[68],"then":[70],"help":[73],"support":[75],"vector":[76],"machine":[77],"(SVM),":[78],"established":[80],"an":[81],"experiment":[82,125],"process":[83],"for":[84,249],"discovering":[85],"potential":[86],"investigating":[90],"mechanisms":[92],"them":[97],"advance":[99],"field":[104],"four":[105,187],"types":[106],"models,":[109],"referring":[110],"activity,":[113],"permeability,":[115],"passive":[116],"diffusion":[117],"efflux":[119],"transport,":[120],"were":[121,131,153,179,190,204,211],"obtained":[122],"process.":[126],"first":[128],"two":[129,152],"models":[130,189,210],"used":[132,154,180],"discover":[134],"which":[136],"may":[137,229],"have":[138],"activity":[140,222],"also":[142],"cross":[143],"at":[146],"same":[148],"time;":[149],"latter":[151],"elucidate":[156],"mechanism":[158],"those":[163],"compounds.":[164],"Three":[165],"optimization":[166],"parameter":[167],"methods,":[168],"Grid":[169],"Search,":[170],"Genetic":[171],"Algorithm":[172],"(GA),":[173],"Particle":[175],"Swarm":[176],"Optimization":[177],"(PSO),":[178],"optimize":[182],"SVM":[184],"models.":[185],"Then,":[186],"optimal":[188],"selected":[191],"excellent":[193],"evaluation":[194],"indexes":[195],"(the":[196],"accuracy,":[197],"sensitivity":[198],"specificity":[200],"each":[202],"model":[203],"all":[205],"above":[206],"85%).":[207],"Furthermore,":[208],"discrimination":[209],"utilized":[212],"study":[214],"properties":[217],"known":[220],"Chinese":[225,247],"herbs":[226],"guide":[230],"drug":[233],"development.":[234],"With":[235],"relatively":[237],"systematic":[238],"quick":[240],"approach,":[241],"application":[243],"rationality":[244],"traditional":[246],"medicines":[248],"treating":[250],"disease":[253],"clinical":[256],"practice":[257],"will":[258],"be":[259],"improved.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}