{"id":"https://openalex.org/W2508788916","doi":"https://doi.org/10.1142/s0219720016440054","title":"Analysis of multiple related phenotypes in genome-wide association studies","display_name":"Analysis of multiple related phenotypes in genome-wide association studies","publication_year":2016,"publication_date":"2016-09-09","ids":{"openalex":"https://openalex.org/W2508788916","doi":"https://doi.org/10.1142/s0219720016440054","mag":"2508788916","pmid":"https://pubmed.ncbi.nlm.nih.gov/27774872"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720016440054","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219720016440054","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219720016440054","source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219720016440054","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042149642","display_name":"Sohee Oh","orcid":"https://orcid.org/0000-0002-3010-448X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sohee Oh","raw_affiliation_strings":["Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001526423","display_name":"Iksoo Huh","orcid":"https://orcid.org/0000-0003-2472-9501"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Iksoo Huh","raw_affiliation_strings":["Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022181385","display_name":"Seung Yeoun Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I28777354","display_name":"Sejong University","ror":"https://ror.org/00aft1q37","country_code":"KR","type":"education","lineage":["https://openalex.org/I28777354"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung Yeoun Lee","raw_affiliation_strings":["Department of Mathematics and Statistics, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, South Korea","institution_ids":["https://openalex.org/I28777354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100643662","display_name":"Taesung Park","orcid":"https://orcid.org/0000-0002-8294-590X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taesung Park","raw_affiliation_strings":["Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042149642"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":0.5739,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77761688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":"05","first_page":"1644005","last_page":"1644005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.8298333883285522},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.7655441761016846},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6680123805999756},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.6547321677207947},{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.6195362210273743},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.6145663857460022},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5738440155982971},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5385701656341553},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.5368173122406006},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5287026166915894},{"id":"https://openalex.org/keywords/missing-heritability-problem","display_name":"Missing heritability problem","score":0.5249186158180237},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.41563040018081665},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3315592408180237},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.16745024919509888},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.11837473511695862},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.057802021503448486}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8298333883285522},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7655441761016846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6680123805999756},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.6547321677207947},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.6195362210273743},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.6145663857460022},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5738440155982971},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5385701656341553},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5368173122406006},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5287026166915894},{"id":"https://openalex.org/C144621757","wikidata":"https://www.wikidata.org/wiki/Q3083720","display_name":"Missing heritability problem","level":5,"score":0.5249186158180237},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41563040018081665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3315592408180237},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.16745024919509888},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11837473511695862},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.057802021503448486}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720016440054","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219720016440054","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219720016440054","source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:27774872","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27774872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":{"id":"doi:10.1142/s0219720016440054","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219720016440054","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219720016440054","source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2508788916.pdf","grobid_xml":"https://content.openalex.org/works/W2508788916.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1154645442","https://openalex.org/W1480934029","https://openalex.org/W1508806100","https://openalex.org/W1579116234","https://openalex.org/W1952660301","https://openalex.org/W1968886567","https://openalex.org/W1982636457","https://openalex.org/W1998979801","https://openalex.org/W2001401424","https://openalex.org/W2025143098","https://openalex.org/W2027350554","https://openalex.org/W2035895978","https://openalex.org/W2041467022","https://openalex.org/W2044707173","https://openalex.org/W2048755332","https://openalex.org/W2051226990","https://openalex.org/W2053725906","https://openalex.org/W2058507142","https://openalex.org/W2059480529","https://openalex.org/W2062549773","https://openalex.org/W2064422331","https://openalex.org/W2066669827","https://openalex.org/W2071759640","https://openalex.org/W2073839243","https://openalex.org/W2081422943","https://openalex.org/W2086702905","https://openalex.org/W2090392937","https://openalex.org/W2097656361","https://openalex.org/W2097695579","https://openalex.org/W2098238559","https://openalex.org/W2103714496","https://openalex.org/W2106069050","https://openalex.org/W2112440119","https://openalex.org/W2120029762","https://openalex.org/W2129407851","https://openalex.org/W2132559433","https://openalex.org/W2133904402","https://openalex.org/W2134783591","https://openalex.org/W2140079333","https://openalex.org/W2140609764","https://openalex.org/W2141532374","https://openalex.org/W2142769596","https://openalex.org/W2150806217","https://openalex.org/W2161527093","https://openalex.org/W2161633633","https://openalex.org/W2163144326","https://openalex.org/W2165999869","https://openalex.org/W2166711199","https://openalex.org/W2166941513","https://openalex.org/W2169189827","https://openalex.org/W2596500039","https://openalex.org/W2794573350","https://openalex.org/W2964947239","https://openalex.org/W4210956151"],"related_works":["https://openalex.org/W2924960962","https://openalex.org/W2004156733","https://openalex.org/W2136285728","https://openalex.org/W159064268","https://openalex.org/W2111896105","https://openalex.org/W2170506381","https://openalex.org/W1987620105","https://openalex.org/W2102533238","https://openalex.org/W1847429134","https://openalex.org/W2144000849"],"abstract_inverted_index":{"Most":[0],"genome-wide":[1,48],"association":[2],"studies":[3],"(GWAS)":[4],"have":[5,104],"been":[6],"conducted":[7],"by":[8,65],"focusing":[9],"on":[10,107],"one":[11],"phenotype":[12,58,142],"of":[13,35,57,120,171],"interest":[14],"for":[15,95,125],"identifying":[16],"genetic":[17,36,98,131],"variants":[18,37,99,102,132],"associated":[19,133],"with":[20,134],"common":[21],"complex":[22,174],"phenotypes.":[23,110,138,175],"However,":[24],"despite":[25],"many":[26,172],"successful":[27],"results":[28,152],"from":[29,69],"GWAS,":[30],"only":[31,53,149],"a":[32,45,54,117],"small":[33,55],"number":[34],"tend":[38],"to":[39,62,116,161,168],"be":[40],"identified":[41],"and":[42,51,100,128],"replicated":[43],"given":[44],"very":[46],"stringent":[47],"significance":[49],"criterion,":[50],"explain":[52],"fraction":[56],"heritability.":[59],"In":[60],"order":[61],"improve":[63,93],"power":[64,94],"using":[66],"more":[67,150],"information":[68],"data,":[70],"we":[71],"propose":[72],"an":[73],"alternative":[74],"multivariate":[75,90,114,145],"approach,":[76],"which":[77],"considers":[78],"multiple":[79,108],"related":[80,109,137,141,173],"phenotypes":[81],"simultaneously.":[82],"We":[83,111],"demonstrate":[84],"through":[85],"computer":[86],"simulation":[87],"that":[88,103,165],"the":[89,113,144,154,169],"approach":[91,115,146,157],"can":[92],"detecting":[96],"disease-predisposing":[97],"pleiotropic":[101,163],"simultaneous":[105],"effects":[106],"apply":[112],"GWA":[118],"dataset":[119],"8,842":[121],"Korean":[122],"individuals":[123],"genotyped":[124],"327,872":[126],"SNPs,":[127],"detect":[129],"novel":[130],"metabolic":[135],"syndrome":[136],"Considering":[139],"several":[140],"simultaneously,":[143],"provides":[147],"not":[148],"powerful":[151],"than":[153],"conventional":[155],"univariate":[156],"but":[158],"also":[159],"clue":[160],"identify":[162],"genes":[164],"are":[166],"important":[167],"pathogenesis":[170]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}