{"id":"https://openalex.org/W2111342151","doi":"https://doi.org/10.1142/s0219720013500017","title":"RNAiFOLD: A CONSTRAINT PROGRAMMING ALGORITHM FOR RNA INVERSE FOLDING AND MOLECULAR DESIGN","display_name":"RNAiFOLD: A CONSTRAINT PROGRAMMING ALGORITHM FOR RNA INVERSE FOLDING AND MOLECULAR DESIGN","publication_year":2012,"publication_date":"2012-11-29","ids":{"openalex":"https://openalex.org/W2111342151","doi":"https://doi.org/10.1142/s0219720013500017","mag":"2111342151","pmid":"https://pubmed.ncbi.nlm.nih.gov/23600819"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720013500017","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720013500017","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006388602","display_name":"Juan Antonio Garc\u00eda-Mart\u00edn","orcid":"https://orcid.org/0000-0003-0993-4064"},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JUAN ANTONIO GARCIA-MARTIN","raw_affiliation_strings":["CNB-CSIC, Darwin 3, Campus Cantoblanco, 28049 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNB-CSIC, Darwin 3, Campus Cantoblanco, 28049 Madrid, Spain","institution_ids":["https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038186958","display_name":"Peter Clote","orcid":"https://orcid.org/0000-0003-3628-2874"},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PETER CLOTE","raw_affiliation_strings":["Biology Department, Boston College, 140 Commonwealth Avenue Chestnut Hill, MA, 02467, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Boston College, 140 Commonwealth Avenue Chestnut Hill, MA, 02467, USA","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059708538","display_name":"Iv\u00e1n Dot\u00fa","orcid":"https://orcid.org/0000-0002-0438-9557"},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"IVAN DOTU","raw_affiliation_strings":["Biology Department, Boston College, 140 Commonwealth Avenue Chestnut Hill, MA, 02467, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Boston College, 140 Commonwealth Avenue Chestnut Hill, MA, 02467, USA","institution_ids":["https://openalex.org/I103531236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7078,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.94078125,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"02","first_page":"1350001","last_page":"1350001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.7904614210128784},{"id":"https://openalex.org/keywords/pseudoknot","display_name":"Pseudoknot","score":0.6403450965881348},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6108484268188477},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5555680394172668},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4861833453178406},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.4401733875274658},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4383115768432617},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4382810592651367},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2363785207271576},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1227884590625763},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11075964570045471},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10238903760910034}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.7904614210128784},{"id":"https://openalex.org/C105130999","wikidata":"https://www.wikidata.org/wiki/Q414976","display_name":"Pseudoknot","level":4,"score":0.6403450965881348},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6108484268188477},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5555680394172668},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4861833453178406},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.4401733875274658},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4383115768432617},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4382810592651367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2363785207271576},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1227884590625763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11075964570045471},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10238903760910034},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058928","descriptor_name":"Riboswitch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058928","descriptor_name":"Riboswitch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058928","descriptor_name":"Riboswitch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059370","descriptor_name":"RNA Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059370","descriptor_name":"RNA Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059370","descriptor_name":"RNA Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720013500017","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720013500017","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:23600819","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23600819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.49000000953674316,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1497378428","https://openalex.org/W1543796220","https://openalex.org/W1591532012","https://openalex.org/W1595498733","https://openalex.org/W1920564293","https://openalex.org/W1965994418","https://openalex.org/W1967517087","https://openalex.org/W1973338329","https://openalex.org/W1975946664","https://openalex.org/W1978525780","https://openalex.org/W1980410097","https://openalex.org/W1981119631","https://openalex.org/W1983578222","https://openalex.org/W1984675364","https://openalex.org/W1991635760","https://openalex.org/W1995612793","https://openalex.org/W1999096372","https://openalex.org/W2000473052","https://openalex.org/W2004945910","https://openalex.org/W2009818318","https://openalex.org/W2010986636","https://openalex.org/W2012593394","https://openalex.org/W2012827232","https://openalex.org/W2014790936","https://openalex.org/W2015224936","https://openalex.org/W2017313617","https://openalex.org/W2018216725","https://openalex.org/W2025763720","https://openalex.org/W2030492311","https://openalex.org/W2033695654","https://openalex.org/W2042332384","https://openalex.org/W2044020586","https://openalex.org/W2045777307","https://openalex.org/W2051713039","https://openalex.org/W2054167614","https://openalex.org/W2055060972","https://openalex.org/W2061930808","https://openalex.org/W2067810191","https://openalex.org/W2076756368","https://openalex.org/W2084875499","https://openalex.org/W2084943154","https://openalex.org/W2085720218","https://openalex.org/W2087072039","https://openalex.org/W2100641920","https://openalex.org/W2102020517","https://openalex.org/W2103250001","https://openalex.org/W2108298758","https://openalex.org/W2113983551","https://openalex.org/W2114001343","https://openalex.org/W2119582819","https://openalex.org/W2122944508","https://openalex.org/W2124191447","https://openalex.org/W2125615424","https://openalex.org/W2126244322","https://openalex.org/W2130682154","https://openalex.org/W2134036931","https://openalex.org/W2135261987","https://openalex.org/W2135373808","https://openalex.org/W2140651796","https://openalex.org/W2141157874","https://openalex.org/W2143407915","https://openalex.org/W2148339059","https://openalex.org/W2153461732","https://openalex.org/W2154241726","https://openalex.org/W2161381662","https://openalex.org/W2324447404","https://openalex.org/W2400250419","https://openalex.org/W4293662999"],"related_works":["https://openalex.org/W2057901482","https://openalex.org/W2018280025","https://openalex.org/W1998399688","https://openalex.org/W2981287558","https://openalex.org/W2022565929","https://openalex.org/W2054306371","https://openalex.org/W2012192331","https://openalex.org/W2007550449","https://openalex.org/W2017993626","https://openalex.org/W2792232401"],"abstract_inverted_index":{"Synthetic":[0],"biology":[1,78],"is":[2,132,215],"a":[3,62,97,110,139,159,168],"rapidly":[4],"emerging":[5],"discipline":[6],"with":[7],"long-term":[8],"ramifications":[9],"that":[10,74,199,251],"range":[11,161],"from":[12,250],"single-molecule":[13],"detection":[14],"within":[15],"cells":[16],"to":[17,61,82,102,176],"the":[18,37,84,89,104,123,133,146,156,181,188,223,239,244],"creation":[19],"of":[20,40,88,158,162,183,190,219,225],"synthetic":[21,77],"genomes":[22],"and":[23,47,76,222],"novel":[24],"life":[25],"forms.":[26],"Truly":[27],"phenomenal":[28],"results":[29],"have":[30],"been":[31],"obtained":[32],"by":[33],"pioneering":[34],"groups--for":[35],"instance,":[36],"combinatorial":[38],"synthesis":[39,44],"genetic":[41],"networks,":[42],"genome":[43],"using":[45],"BioBricks,":[46],"hybridization":[48],"chain":[49],"reaction":[50],"(HCR),":[51],"in":[52,142,217,232],"which":[53,120,153,173],"stable":[54],"DNA":[55,64],"monomers":[56],"assemble":[57],"only":[58],"upon":[59],"exposure":[60],"target":[63,111,124,134],"fragment,":[65],"biomolecular":[66],"self-assembly":[67],"pathways,":[68],"etc.":[69],"Such":[70],"work":[71],"strongly":[72],"suggests":[73],"nanotechnology":[75],"together":[79],"seem":[80],"poised":[81],"constitute":[83],"most":[85],"transformative":[86],"development":[87],"21st":[90],"century.":[91],"In":[92],"this":[93,233],"paper,":[94],"we":[95,115],"present":[96],"Constraint":[98],"Programming":[99],"(CP)":[100],"approach":[101,137,152,172,214],"solve":[103],"RNA":[105,112,118,143,149],"inverse":[106,150],"folding":[107,151],"problem.":[108],"Given":[109],"secondary":[113],"structure,":[114],"determine":[116],"an":[117],"sequence":[119],"folds":[121],"into":[122],"structure;":[125],"i.e.":[126],"whose":[127],"minimum":[128],"free":[129],"energy":[130],"structure":[131],"structure.":[135],"Our":[136],"represents":[138],"step":[140],"forward":[141],"design--we":[144],"produce":[145],"first":[147],"complete":[148],"allows":[154,174],"for":[155],"specification":[157],"wide":[160],"design":[163,192,227],"constraints.":[164,228],"We":[165],"also":[166],"introduce":[167],"Large":[169],"Neighborhood":[170],"Search":[171],"us":[175],"tackle":[177],"larger":[178],"instances":[179],"at":[180],"cost":[182],"losing":[184],"completeness,":[185,220],"while":[186],"retaining":[187],"advantages":[189],"meeting":[191],"constraints":[193],"(motif,":[194],"GC-content,":[195],"etc.).":[196],"Results":[197],"demonstrate":[198],"our":[200,213],"software,":[201],"RNAiFold,":[202],"performs":[203],"as":[204],"well":[205],"or":[206],"better":[207],"than":[208],"all":[209],"state-of-the-art":[210],"approaches;":[211],"nevertheless,":[212],"unique":[216],"terms":[218],"flexibility,":[221],"support":[224],"various":[226],"The":[229],"algorithms":[230],"presented":[231],"paper":[234],"are":[235],"publicly":[236],"available":[237],"via":[238],"interactive":[240],"webserver":[241],"http://bioinformatics.bc.edu/clotelab/RNAiFold;":[242],"additionally,":[243],"source":[245],"code":[246],"can":[247],"be":[248],"downloaded":[249],"site.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}