{"id":"https://openalex.org/W2099500965","doi":"https://doi.org/10.1142/s0219720012410089","title":"DERIVED SNP ALLELES ARE USED MORE FREQUENTLY THAN ANCESTRAL ALLELES AS RISK-ASSOCIATED VARIANTS IN COMMON HUMAN DISEASES","display_name":"DERIVED SNP ALLELES ARE USED MORE FREQUENTLY THAN ANCESTRAL ALLELES AS RISK-ASSOCIATED VARIANTS IN COMMON HUMAN DISEASES","publication_year":2012,"publication_date":"2012-01-19","ids":{"openalex":"https://openalex.org/W2099500965","doi":"https://doi.org/10.1142/s0219720012410089","mag":"2099500965","pmid":"https://pubmed.ncbi.nlm.nih.gov/22809343"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720012410089","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720012410089","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077624751","display_name":"Olga Y. Gorlova","orcid":"https://orcid.org/0000-0001-8241-6322"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"OLGA Y. GORLOVA","raw_affiliation_strings":["Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030-3721, USA"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030-3721, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088115066","display_name":"Binwu Ying","orcid":"https://orcid.org/0000-0001-8077-3908"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JUN YING","raw_affiliation_strings":["Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030-3721, USA"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030-3721, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028989565","display_name":"Christopher I. Amos","orcid":"https://orcid.org/0000-0002-8540-7023"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHRISTOPHER I. AMOS","raw_affiliation_strings":["Department of Genetics, Unit 209, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Unit 209, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109231357","display_name":"Margaret R. Spitz","orcid":null},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARGARET R. SPITZ","raw_affiliation_strings":["Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030-3721, USA"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030-3721, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025424500","display_name":"Bo Peng","orcid":"https://orcid.org/0000-0001-8225-2284"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BO PENG","raw_affiliation_strings":["Department of Genetics, Unit 209, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Unit 209, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031124240","display_name":"Ivan P. Gorlov","orcid":null},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"IVAN P. GORLOV","raw_affiliation_strings":["Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030-3721, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030-3721, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5077624751"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.8283,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76664391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"02","first_page":"1241008","last_page":"1241008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.8344267010688782},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.764155387878418},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.7470964193344116},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"Linkage disequilibrium","score":0.6280233860015869},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5670818090438843},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"Genetic architecture","score":0.49599871039390564},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.4945361316204071},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"Allele frequency","score":0.4801589846611023},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.42293310165405273},{"id":"https://openalex.org/keywords/fixation","display_name":"Fixation (population genetics)","score":0.41975271701812744},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.4131402373313904},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.28104281425476074},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.2122603952884674},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.21043702960014343},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1697457730770111},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.13807711005210876},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.09656369686126709}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.8344267010688782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.764155387878418},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7470964193344116},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6280233860015869},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5670818090438843},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.49599871039390564},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4945361316204071},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.4801589846611023},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.42293310165405273},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.41975271701812744},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4131402373313904},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.28104281425476074},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.2122603952884674},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.21043702960014343},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1697457730770111},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.13807711005210876},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.09656369686126709},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1142/s0219720012410089","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720012410089","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:22809343","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22809343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2653217","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3655427","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1561011655","https://openalex.org/W1996604505","https://openalex.org/W2014469644","https://openalex.org/W2036815268","https://openalex.org/W2042367595","https://openalex.org/W2051616601","https://openalex.org/W2079958890","https://openalex.org/W2091390191","https://openalex.org/W2097349182","https://openalex.org/W2115633449","https://openalex.org/W2119612189","https://openalex.org/W2123340910","https://openalex.org/W2140784970","https://openalex.org/W2143277946","https://openalex.org/W2150853937","https://openalex.org/W2153555867"],"related_works":["https://openalex.org/W2187968078","https://openalex.org/W1523912222","https://openalex.org/W1480804049","https://openalex.org/W1965385715","https://openalex.org/W4212923765","https://openalex.org/W1998165549","https://openalex.org/W2477193377","https://openalex.org/W2800726709","https://openalex.org/W2131251647","https://openalex.org/W1603579433"],"abstract_inverted_index":{"Evolutionary":[0],"aspects":[1],"of":[2,6,14,45,61,78,116,125,152,162,164],"the":[3,71,79,93,126,160,186],"genetic":[4,150],"architecture":[5,151],"common":[7,114,153],"human":[8,46],"diseases":[9],"remain":[10],"enigmatic.":[11],"The":[12,113],"results":[13,156],"more":[15,48,100,171],"than":[16,50,106],"200":[17],"genome-wide":[18],"association":[19,118],"studies":[20],"published":[21],"to":[22,34,102,177,193],"date":[23],"were":[24],"compiled":[25],"in":[26,65,167],"a":[27,146,168,195],"catalog":[28],"().":[29],"We":[30,53,68],"used":[31],"cataloged":[32],"data":[33],"determine":[35],"whether":[36],"derived":[37,97],"(mutant)":[38],"alleles":[39,98,143],"are":[40,99,110,190],"associated":[41,105],"with":[42,182],"higher":[43],"risk":[44,87,104,127],"disease":[47,86,130],"frequently":[49],"ancestral":[51,107],"alleles.":[52,112],"placed":[54],"all":[55],"allelic":[56,74],"variants":[57],"into":[58],"ten":[59],"categories":[60],"population":[62,95,169],"frequency":[63],"(0%-100%)":[64],"10%":[66],"increments.":[67],"then":[69],"analyzed":[70],"relationship":[72],"between":[73],"frequency,":[75,96],"evolutionary":[76],"status":[77,88],"polymorphic":[80],"site":[81],"(ancestral":[82],"versus":[83,90],"derived),":[84],"and":[85,189],"(risk":[89],"protection).":[91],"Given":[92],"same":[94],"likely":[101,192],"be":[103],"alleles,":[108,184,188],"as":[109,132],"rarer":[111],"interpretation":[115],"this":[117],"is":[119,144,170],"that":[120,138,159],"negative":[121],"selection":[122,140],"prevents":[123],"fixation":[124],"variants.":[128],"However,":[129],"stratification":[131],"early":[133],"or":[134],"late":[135],"onset":[136],"suggests":[137],"weak":[139],"against":[141],"risk-associated":[142],"unlikely":[145],"major":[147],"factor":[148],"shaping":[149],"diseases.":[154],"Our":[155],"clearly":[157],"suggest":[158],"duration":[161],"existence":[163],"an":[165],"allele":[166],"important.":[172],"Alleles":[173],"existing":[174],"longer":[175],"tend":[176],"show":[178],"weaker":[179],"linkage":[180],"disequilibrium":[181],"neighboring":[183],"including":[185],"causal":[187],"less":[191],"tag":[194],"SNP-disease":[196],"association.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}