{"id":"https://openalex.org/W2007447861","doi":"https://doi.org/10.1142/s0219720012400057","title":"GENERATION OF SYNTHETIC DATA AND EXPERIMENTAL DESIGNS IN EVALUATING INTERACTIONS FOR ASSOCIATION STUDIES","display_name":"GENERATION OF SYNTHETIC DATA AND EXPERIMENTAL DESIGNS IN EVALUATING INTERACTIONS FOR ASSOCIATION STUDIES","publication_year":2011,"publication_date":"2011-12-29","ids":{"openalex":"https://openalex.org/W2007447861","doi":"https://doi.org/10.1142/s0219720012400057","mag":"2007447861","pmid":"https://pubmed.ncbi.nlm.nih.gov/22809306"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720012400057","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720012400057","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002028926","display_name":"Yixuan Chen","orcid":"https://orcid.org/0000-0001-6732-3961"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"YIXUAN CHEN","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100337051","display_name":"Jing Li","orcid":"https://orcid.org/0000-0003-1160-6959"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JING LI","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002028926"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.5869,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71226787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"01","first_page":"1240005","last_page":"1240005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7440289258956909},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5482462644577026},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.5395549535751343},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.5259097814559937},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.4989016056060791},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4854314923286438},{"id":"https://openalex.org/keywords/web-application","display_name":"Web application","score":0.4138338565826416},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.37716448307037354},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.1317649483680725},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.113579660654068}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7440289258956909},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5482462644577026},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5395549535751343},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5259097814559937},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.4989016056060791},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4854314923286438},{"id":"https://openalex.org/C118643609","wikidata":"https://www.wikidata.org/wiki/Q189210","display_name":"Web application","level":2,"score":0.4138338565826416},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37716448307037354},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.1317649483680725},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.113579660654068},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720012400057","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720012400057","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:22809306","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22809306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1979090539","https://openalex.org/W1980175560","https://openalex.org/W2004897641","https://openalex.org/W2015523078","https://openalex.org/W2041170649","https://openalex.org/W2098979053","https://openalex.org/W2108373834","https://openalex.org/W2116195838","https://openalex.org/W2126896167","https://openalex.org/W2155635136","https://openalex.org/W2162530578","https://openalex.org/W2163199046"],"related_works":["https://openalex.org/W3143779693","https://openalex.org/W2626808643","https://openalex.org/W2004064826","https://openalex.org/W3103727510","https://openalex.org/W97045569","https://openalex.org/W2946179579","https://openalex.org/W2348021072","https://openalex.org/W1871370349","https://openalex.org/W1508207170","https://openalex.org/W2168300075"],"abstract_inverted_index":{"Complex":[0],"diseases,":[1],"by":[2,124],"definition,":[3],"involve":[4],"multiple":[5],"factors,":[6],"including":[7],"gene-gene":[8],"interactions":[9,26,44],"and":[10,42,93],"gene-environment":[11],"interactions.":[12],"Researchers":[13],"commonly":[14],"rely":[15],"on":[16],"simulated":[17,144],"data":[18,87],"to":[19,36,49,83,95,102,115,118],"evaluate":[20],"their":[21],"approaches":[22],"for":[23],"detecting":[24],"high-order":[25],"in":[27,142],"disease":[28],"gene":[29],"mapping.":[30],"A":[31],"publicly":[32],"available":[33],"simulation":[34],"program":[35],"generate":[37,84],"samples":[38],"involving":[39],"complex":[40,120],"genetic":[41],"environmental":[43],"is":[45],"of":[46],"great":[47,91],"interest":[48],"the":[50],"community.":[51],"We":[52],"have":[53,133],"developed":[54],"a":[55,103,106],"software":[56],"package":[57],"named":[58],"gs1.0,":[59],"which":[60,77],"has":[61,111],"been":[62,112],"widely":[63],"used":[64],"since":[65],"its":[66,81],"publication.":[67],"In":[68,100],"this":[69],"article,":[70],"we":[71,132],"present":[72],"an":[73,130],"upgraded":[74],"version":[75],"gs2.0,":[76],"not":[78],"only":[79],"inherits":[80],"capacity":[82],"realistic":[85,136],"genotype":[86],"but":[88],"also":[89],"provides":[90],"functionality":[92],"flexibility":[94],"simulate":[96],"various":[97],"interaction":[98,121],"models.":[99,122],"addition":[101],"standalone":[104],"version,":[105],"user-friendly":[107],"web":[108],"server":[109],"(http://cbc.case.edu/gs)":[110],"set":[113],"up":[114],"help":[116],"users":[117],"build":[119],"Furthermore,":[123],"utilizing":[125],"three":[126],"three-locus":[127],"models":[128],"as":[129],"example,":[131],"shown":[134],"how":[135],"model":[137],"parameters":[138],"can":[139],"be":[140],"chosen":[141],"generating":[143],"data.":[145]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}