{"id":"https://openalex.org/W2005786953","doi":"https://doi.org/10.1142/s0219720012400033","title":"A NEW METABOLOMICS ANALYSIS TECHNIQUE: STEADY-STATE METABOLIC NETWORK DYNAMICS ANALYSIS","display_name":"A NEW METABOLOMICS ANALYSIS TECHNIQUE: STEADY-STATE METABOLIC NETWORK DYNAMICS ANALYSIS","publication_year":2011,"publication_date":"2011-12-29","ids":{"openalex":"https://openalex.org/W2005786953","doi":"https://doi.org/10.1142/s0219720012400033","mag":"2005786953","pmid":"https://pubmed.ncbi.nlm.nih.gov/22809304"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720012400033","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720012400033","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035836413","display_name":"Ali Cakmak","orcid":"https://orcid.org/0000-0002-1382-6130"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ALI CAKMAK","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100913092","display_name":"Xinjian Qi","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"XINJIAN QI","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090836372","display_name":"A. Erc\u00fcment \u00c7i\u00e7ek","orcid":"https://orcid.org/0000-0001-8613-6619"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. ERCUMENT CICEK","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027338915","display_name":"Ilya Bederman","orcid":"https://orcid.org/0000-0002-1909-5746"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ILYA BEDERMAN","raw_affiliation_strings":["Department of Pediatric Pulmonology, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045668542","display_name":"Leigh Henderson","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LEIGH HENDERSON","raw_affiliation_strings":["Department of Pediatric Pulmonology, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031300278","display_name":"Mitchell L. Drumm","orcid":"https://orcid.org/0000-0003-4739-5153"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MITCHELL DRUMM","raw_affiliation_strings":["Department of Pediatric Pulmonology, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016412404","display_name":"G\u00fcltekin \u00d6zsoyo\u011flu","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GULTEKIN OZSOYOGLU","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave. Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.7869,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70220798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"01","first_page":"1240003","last_page":"1240003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.7692757844924927},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.7295873165130615},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6310744285583496},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.5484403967857361},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5135219693183899},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.48451584577560425},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.4748119115829468},{"id":"https://openalex.org/keywords/exponential-growth","display_name":"Exponential growth","score":0.4367876648902893},{"id":"https://openalex.org/keywords/network-dynamics","display_name":"Network dynamics","score":0.4252541661262512},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.377760112285614},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3498114347457886},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.34306809306144714},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.268721342086792},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2504475712776184},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22401997447013855},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22231408953666687}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7692757844924927},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.7295873165130615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6310744285583496},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.5484403967857361},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5135219693183899},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.48451584577560425},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.4748119115829468},{"id":"https://openalex.org/C75235859","wikidata":"https://www.wikidata.org/wiki/Q582659","display_name":"Exponential growth","level":2,"score":0.4367876648902893},{"id":"https://openalex.org/C123757187","wikidata":"https://www.wikidata.org/wiki/Q9195957","display_name":"Network dynamics","level":2,"score":0.4252541661262512},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.377760112285614},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3498114347457886},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.34306809306144714},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.268721342086792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2504475712776184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22401997447013855},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22231408953666687},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1142/s0219720012400033","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720012400033","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:22809304","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22809304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:3094152","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4123123","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.699999988079071,"display_name":"Zero hunger"}],"awards":[{"id":"https://openalex.org/G2374891109","display_name":null,"funder_award_id":"P30 DK027651","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G855456172","display_name":null,"funder_award_id":"R01 GM088823","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W56055795","https://openalex.org/W1561767438","https://openalex.org/W1574470162","https://openalex.org/W1758395617","https://openalex.org/W1994656497","https://openalex.org/W1996529795","https://openalex.org/W2029058413","https://openalex.org/W2037377131","https://openalex.org/W2037614307","https://openalex.org/W2042141122","https://openalex.org/W2046760236","https://openalex.org/W2061904489","https://openalex.org/W2065432632","https://openalex.org/W2079733254","https://openalex.org/W2084150266","https://openalex.org/W2098824895","https://openalex.org/W2116324021","https://openalex.org/W2137321945","https://openalex.org/W2141470945","https://openalex.org/W2167909188","https://openalex.org/W2170739315","https://openalex.org/W2171560951"],"related_works":["https://openalex.org/W4283390424","https://openalex.org/W2137270828","https://openalex.org/W1976072307","https://openalex.org/W4205440119","https://openalex.org/W1561393703","https://openalex.org/W4292104203","https://openalex.org/W2799517538","https://openalex.org/W2092184761","https://openalex.org/W2082598680","https://openalex.org/W2415529743"],"abstract_inverted_index":{"With":[0],"the":[1,14,45,53,60,64,81,108,122,129,134,144,154],"recent":[2],"advances":[3],"in":[4,22,52,67,89,95,128],"experimental":[5],"technologies,":[6],"such":[7,33],"as":[8],"gas":[9],"chromatography":[10],"and":[11,58,147,151],"mass":[12],"spectrometry,":[13],"number":[15,130],"of":[16,24,32,55,63,69,107,121,131,133,140,153],"metabolites":[17,57],"that":[18,48],"can":[19],"be":[20],"measured":[21],"biofluids":[23],"individuals":[25],"has":[26],"markedly":[27],"increased.":[28],"Given":[29],"a":[30,35,96,103,112],"set":[31],"measurements,":[34],"very":[36],"common":[37],"task":[38],"encountered":[39],"by":[40],"biologists":[41],"is":[42,125,158],"to":[43,50,160,163],"identify":[44],"metabolic":[46,61,83,114],"mechanisms":[47],"lead":[49],"changes":[51,66],"concentrations":[54],"given":[56],"interpret":[59],"consequences":[62],"observed":[65],"terms":[68],"physiological":[70],"problems,":[71],"nutritional":[72],"deficiencies,":[73],"or":[74],"diseases.":[75],"In":[76],"this":[77],"paper,":[78],"we":[79],"present":[80,102],"steady-state":[82],"network":[84,115],"dynamics":[85],"analysis":[86],"(SMDA)":[87],"approach":[88],"detail,":[90],"together":[91],"with":[92],"its":[93],"application":[94],"cystic":[97],"fibrosis":[98],"study.":[99],"We":[100],"also":[101],"computational":[104],"performance":[105],"evaluation":[106],"SMDA":[109,123],"tool":[110,124],"against":[111],"mammalian":[113],"database.":[116],"The":[117],"query":[118,155],"output":[119,145,156],"space":[120,157],"exponentially":[126,142],"large":[127],"reactions":[132],"network.":[135],"However,":[136],"(i)":[137],"larger":[138],"numbers":[139],"observations":[141],"reduce":[143],"size,":[146],"(ii)":[148],"exploratory":[149],"search":[150,164],"browsing":[152],"provided":[159],"allow":[161],"users":[162],"for":[165],"what":[166],"they":[167],"are":[168],"looking":[169],"for.":[170]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}