{"id":"https://openalex.org/W2074446945","doi":"https://doi.org/10.1142/s0219720012400021","title":"RANKING DIFFERENTIAL HUBS IN GENE CO-EXPRESSION NETWORKS","display_name":"RANKING DIFFERENTIAL HUBS IN GENE CO-EXPRESSION NETWORKS","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2074446945","doi":"https://doi.org/10.1142/s0219720012400021","mag":"2074446945","pmid":"https://pubmed.ncbi.nlm.nih.gov/22809303"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720012400021","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720012400021","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017889995","display_name":"Omar Odibat","orcid":null},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"OMAR ODIBAT","raw_affiliation_strings":["Department of Computer Science, Wayne State University, Detroit, MI 48228, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Wayne State University, Detroit, MI 48228, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001022750","display_name":"Chandan K. Reddy","orcid":"https://orcid.org/0000-0003-2839-3662"},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHANDAN K. REDDY","raw_affiliation_strings":["Department of Computer Science, Wayne State University, Detroit, MI 48228, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Wayne State University, Detroit, MI 48228, USA","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017889995"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":null,"apc_paid":null,"fwci":1.2007,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.77947919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"01","first_page":"1240002","last_page":"1240002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.7017316222190857},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.6925786733627319},{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.6723260283470154},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.649168848991394},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6273561120033264},{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.6134387254714966},{"id":"https://openalex.org/keywords/measure","display_name":"Measure (data warehouse)","score":0.5863311290740967},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.5166678428649902},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4895063638687134},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4411279559135437},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3981180191040039},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3931800127029419},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27400410175323486},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24029552936553955},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16879233717918396},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11737388372421265},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08544254302978516},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08135226368904114}],"concepts":[{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.7017316222190857},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.6925786733627319},{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.6723260283470154},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.649168848991394},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6273561120033264},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.6134387254714966},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.5863311290740967},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.5166678428649902},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4895063638687134},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4411279559135437},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3981180191040039},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3931800127029419},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27400410175323486},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24029552936553955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16879233717918396},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11737388372421265},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08544254302978516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08135226368904114},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720012400021","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720012400021","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:22809303","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22809303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1486784550","https://openalex.org/W1607516807","https://openalex.org/W1854214752","https://openalex.org/W1965055200","https://openalex.org/W1971937094","https://openalex.org/W2008620264","https://openalex.org/W2014478203","https://openalex.org/W2020652317","https://openalex.org/W2031947549","https://openalex.org/W2069733150","https://openalex.org/W2095833325","https://openalex.org/W2096606586","https://openalex.org/W2098636939","https://openalex.org/W2099656145","https://openalex.org/W2102043440","https://openalex.org/W2104812688","https://openalex.org/W2109363337","https://openalex.org/W2124168655","https://openalex.org/W2125814131","https://openalex.org/W2128085074","https://openalex.org/W2131933020","https://openalex.org/W2139329624","https://openalex.org/W2141925314","https://openalex.org/W2157795344","https://openalex.org/W2158217645","https://openalex.org/W2158219396","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2892175958","https://openalex.org/W2348066662","https://openalex.org/W1992392028","https://openalex.org/W2619839850","https://openalex.org/W2768685411","https://openalex.org/W2753828065","https://openalex.org/W2148556617","https://openalex.org/W4301829743","https://openalex.org/W2949526662","https://openalex.org/W2074446945"],"abstract_inverted_index":{"Identifying":[0],"the":[1,24,38,46,64,75,80,94,101,104,138,141,147,156,166,198,203,214],"genes":[2,49,65,95,148],"that":[3,19,190,213],"change":[4],"their":[5,68,98],"expressions":[6],"between":[7,103],"two":[8,51,105,113],"conditions":[9],"(such":[10],"as":[11,32],"normal":[12],"versus":[13],"cancer)":[14],"is":[15],"a":[16,33,88,118,125,171],"crucial":[17],"task":[18],"can":[20],"help":[21],"in":[22,40,79],"understanding":[23],"causes":[25],"of":[26,63,158],"diseases.":[27],"Differential":[28],"networking":[29],"has":[30],"emerged":[31],"powerful":[34],"approach":[35],"to":[36,44,100],"detect":[37],"changes":[39,78],"network":[41,81,142],"structures":[42],"and":[43,124,144,162,179,211],"identify":[45],"differentially":[47],"connected":[48],"among":[50],"networks.":[52,106],"However,":[53],"existing":[54,185,195],"differential":[55,176],"network-based":[56],"methods":[57,72],"primarily":[58],"depend":[59],"on":[60,67,97,150,160,206],"pairwise":[61],"comparisons":[62,188],"based":[66,96,149],"connectivity.":[69],"Therefore,":[70],"these":[71,151,194],"cannot":[73],"capture":[74],"essential":[76],"topological":[77],"structures.":[82],"In":[83],"this":[84,109],"paper,":[85],"we":[86,111,169,180,201],"propose":[87],"novel":[89,114],"algorithm,":[90],"DiffRank,":[91],"which":[92],"ranks":[93],"contribution":[99],"differences":[102],"To":[107],"achieve":[108],"goal,":[110],"define":[112],"structural":[115],"scoring":[116],"measures:":[117],"local":[119],"structure":[120,127,143],"measure":[121,128],"(differential":[122,129],"connectivity)":[123],"global":[126],"betweenness":[130],"centrality).":[131],"These":[132],"measures":[133],"are":[134],"optimized":[135],"by":[136],"propagating":[137],"scores":[139],"through":[140],"then":[145],"ranking":[146],"propagated":[152],"scores.":[153],"We":[154],"demonstrate":[155,212],"effectiveness":[157],"DiffRank":[159],"synthetic":[161,167,175],"real":[163,199],"datasets.":[164],"For":[165,197],"datasets,":[168,200],"developed":[170],"simulator":[172],"for":[173],"generating":[174],"scale-free":[177],"networks,":[178],"compared":[181],"our":[182,191],"method":[183,216],"with":[184],"methods.":[186,196],"The":[187],"show":[189],"algorithm":[192,205],"outperforms":[193],"apply":[202],"proposed":[204,215],"several":[207],"gene":[208],"expression":[209],"datasets":[210],"provides":[217],"biologically":[218],"interesting":[219],"results.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-23T09:07:50.710637","created_date":"2025-10-10T00:00:00"}
