{"id":"https://openalex.org/W2072282691","doi":"https://doi.org/10.1142/s0219720011005707","title":"A SYSTEMS BIOLOGY APPROACH FOR DETECTING TOXICITY-RELATED HOTSPOTS INSIDE PROTEIN INTERACTION NETWORKS","display_name":"A SYSTEMS BIOLOGY APPROACH FOR DETECTING TOXICITY-RELATED HOTSPOTS INSIDE PROTEIN INTERACTION NETWORKS","publication_year":2011,"publication_date":"2011-08-23","ids":{"openalex":"https://openalex.org/W2072282691","doi":"https://doi.org/10.1142/s0219720011005707","mag":"2072282691","pmid":"https://pubmed.ncbi.nlm.nih.gov/21976381"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720011005707","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720011005707","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062690666","display_name":"K. A. Desai","orcid":"https://orcid.org/0000-0001-5103-9480"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]},{"id":"https://openalex.org/I210824098","display_name":"Wilmington University","ror":"https://ror.org/00jrtvk29","country_code":"US","type":"education","lineage":["https://openalex.org/I210824098"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"KAUSHAL DESAI","raw_affiliation_strings":["AstraZeneca Pharmaceuticals, Wilmington, DE 19850, USA","Drexel University, Philadelphia, PA 19104, USA"],"affiliations":[{"raw_affiliation_string":"AstraZeneca Pharmaceuticals, Wilmington, DE 19850, USA","institution_ids":["https://openalex.org/I210824098","https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Drexel University, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073209975","display_name":"David Brott","orcid":null},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]},{"id":"https://openalex.org/I210824098","display_name":"Wilmington University","ror":"https://ror.org/00jrtvk29","country_code":"US","type":"education","lineage":["https://openalex.org/I210824098"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID BROTT","raw_affiliation_strings":["AstraZeneca Pharmaceuticals, Wilmington, DE 19850, USA"],"affiliations":[{"raw_affiliation_string":"AstraZeneca Pharmaceuticals, Wilmington, DE 19850, USA","institution_ids":["https://openalex.org/I210824098","https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101569679","display_name":"Xiaohua Hu","orcid":"https://orcid.org/0000-0002-4777-3022"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"XIAOHUA HU","raw_affiliation_strings":["Drexel University, Philadelphia, PA 19104, USA"],"affiliations":[{"raw_affiliation_string":"Drexel University, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038935506","display_name":"Anastasia Christianson","orcid":null},"institutions":[{"id":"https://openalex.org/I210824098","display_name":"Wilmington University","ror":"https://ror.org/00jrtvk29","country_code":"US","type":"education","lineage":["https://openalex.org/I210824098"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANASTASIA CHRISTIANSON","raw_affiliation_strings":["AstraZeneca Pharmaceuticals, Wilmington, DE 19850, USA"],"affiliations":[{"raw_affiliation_string":"AstraZeneca Pharmaceuticals, Wilmington, DE 19850, USA","institution_ids":["https://openalex.org/I210824098","https://openalex.org/I4210150756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062690666"],"corresponding_institution_ids":["https://openalex.org/I210824098","https://openalex.org/I4210150756","https://openalex.org/I72816309"],"apc_list":null,"apc_paid":null,"fwci":0.6277,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.69559055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"09","issue":"05","first_page":"647","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.6423937082290649},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6276521682739258},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6266113519668579},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5659583210945129},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5659353733062744},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.5152156949043274},{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.4546625018119812},{"id":"https://openalex.org/keywords/human-proteins","display_name":"Human proteins","score":0.43581780791282654},{"id":"https://openalex.org/keywords/neutropenia","display_name":"Neutropenia","score":0.41512322425842285},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"Drug toxicity","score":0.4139874577522278},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3313817083835602},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.25106966495513916},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24338120222091675},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2099144160747528},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20137205719947815}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6423937082290649},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6276521682739258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6266113519668579},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5659583210945129},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5659353733062744},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5152156949043274},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.4546625018119812},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.43581780791282654},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.41512322425842285},{"id":"https://openalex.org/C2992092908","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug toxicity","level":3,"score":0.4139874577522278},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3313817083835602},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25106966495513916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24338120222091675},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2099144160747528},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20137205719947815},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043922","descriptor_name":"Toxicogenetics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D043922","descriptor_name":"Toxicogenetics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D043922","descriptor_name":"Toxicogenetics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720011005707","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720011005707","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:21976381","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21976381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1546909751","https://openalex.org/W1996683133","https://openalex.org/W2003652380","https://openalex.org/W2011670785","https://openalex.org/W2018995955","https://openalex.org/W2033768970","https://openalex.org/W2037454231","https://openalex.org/W2043107521","https://openalex.org/W2070592836","https://openalex.org/W2077137690","https://openalex.org/W2107710781","https://openalex.org/W2112454884","https://openalex.org/W2130687290","https://openalex.org/W2131347449","https://openalex.org/W2131532450","https://openalex.org/W2138551028","https://openalex.org/W2148996267","https://openalex.org/W2152653671","https://openalex.org/W2153972688","https://openalex.org/W2155290699","https://openalex.org/W2155819554","https://openalex.org/W2157673587","https://openalex.org/W2158418435","https://openalex.org/W2296148711"],"related_works":["https://openalex.org/W3129407679","https://openalex.org/W1963702345","https://openalex.org/W2603719983","https://openalex.org/W992989925","https://openalex.org/W1511119527","https://openalex.org/W2620729463","https://openalex.org/W2185904291","https://openalex.org/W2156656908","https://openalex.org/W2801867269","https://openalex.org/W1522260031"],"abstract_inverted_index":{"Drug-induced":[0],"neutropenia":[1,68],"can":[2,121],"be":[3,76,122],"fatal":[4],"when":[5],"severe":[6],"and":[7,113,132],"therefore":[8],"requires":[9],"an":[10,21],"improved":[11],"understanding":[12],"of":[13,16,32,66,126],"its":[14],"mechanism(s)":[15],"toxicity.":[17],"Systems":[18],"biology":[19],"provides":[20],"opportunity":[22],"to":[23,45,52,60,75,78,91],"understand":[24],"adverse":[25],"events":[26],"after":[27],"drug":[28,111],"administration":[29],"using":[30],"analysis":[31,96,125],"biomolecular":[33],"networks.":[34],"In":[35],"this":[36],"study,":[37],"a":[38,56,64],"human":[39],"protein":[40],"interaction":[41],"network":[42],"was":[43],"analyzed":[44],"identify":[46],"proteins":[47,59,72,88,99,114],"that":[48,98],"are":[49,141],"most":[50],"central":[51],"topological":[53,108],"paths":[54,81],"connecting":[55],"drug's":[57],"target":[58],"hematopoiesis-related":[61],"proteins.":[62],"For":[63],"set":[65],"non-immune":[67],"inducing":[69],"drugs,":[70],"9":[71,87],"were":[73],"found":[74],"common":[77],"putative":[79],"signaling":[80],"across":[82],"all":[83],"drugs":[84,131],"evaluated.":[85],"All":[86],"showed":[89,97],"relevance":[90],"neutrophil":[92,117],"biology.":[93],"Geneset":[94],"enrichment":[95],"associated":[100],"with":[101],"cancer-related":[102],"processes":[103,135],"such":[104],"as":[105],"apoptosis":[106],"provide":[107],"linkages":[109],"between":[110],"targets":[112],"involved":[115,136],"in":[116,137],"production.":[118],"The":[119],"algorithm":[120],"applied":[123],"towards":[124],"any":[127],"toxicity":[128],"where":[129],"the":[130,133,138],"physiological":[134],"toxic":[139],"mechanism":[140],"known.":[142]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}