{"id":"https://openalex.org/W2023942263","doi":"https://doi.org/10.1142/s0219720010004963","title":"ANALYSIS OF qPCR DATA BY CONVERTING EXPONENTIALLY RELATED Ct VALUES INTO LINEARLY RELATED X<sub>0</sub> VALUES","display_name":"ANALYSIS OF qPCR DATA BY CONVERTING EXPONENTIALLY RELATED Ct VALUES INTO LINEARLY RELATED X<sub>0</sub> VALUES","publication_year":2010,"publication_date":"2010-06-21","ids":{"openalex":"https://openalex.org/W2023942263","doi":"https://doi.org/10.1142/s0219720010004963","mag":"2023942263","pmid":"https://pubmed.ncbi.nlm.nih.gov/20981893"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720010004963","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720010004963","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101443561","display_name":"Rune Thomsen","orcid":"https://orcid.org/0000-0002-9969-6567"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"RUNE THOMSEN","raw_affiliation_strings":["Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081401787","display_name":"Christina Ane Elisabeth S\u00f8lvsten","orcid":null},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"CHRISTINA ANE ELISABETH S\u00d8LVSTEN","raw_affiliation_strings":["Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007340806","display_name":"TOKE ELBEK LINNET","orcid":null},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"TOKE ELBEK LINNET","raw_affiliation_strings":["Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072542189","display_name":"Jenny Blechingberg","orcid":"https://orcid.org/0000-0002-4110-7459"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"JENNY BLECHINGBERG","raw_affiliation_strings":["Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074820171","display_name":"Anders Lade Nielsen","orcid":"https://orcid.org/0000-0003-4372-9961"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"ANDERS LADE NIELSEN","raw_affiliation_strings":["Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, The Bartholin Buildin, Aarhus University, DK-8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101443561"],"corresponding_institution_ids":["https://openalex.org/I204337017"],"apc_list":null,"apc_paid":null,"fwci":3.253,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.92274586,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"08","issue":"05","first_page":"885","last_page":"900"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9129999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/standard-deviation","display_name":"Standard deviation","score":0.5263270735740662},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.5047057867050171},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.47301343083381653},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.45279914140701294},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3534192740917206},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.33611804246902466},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2577446401119232}],"concepts":[{"id":"https://openalex.org/C22679943","wikidata":"https://www.wikidata.org/wiki/Q159375","display_name":"Standard deviation","level":2,"score":0.5263270735740662},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.5047057867050171},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.47301343083381653},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.45279914140701294},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3534192740917206},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.33611804246902466},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2577446401119232},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720010004963","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720010004963","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:20981893","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20981893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310455","display_name":"Kr\u00e6ftens Bek\u00e6mpelse","ror":"https://ror.org/03ytt7k16"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1577577364","https://openalex.org/W2058665460","https://openalex.org/W2070911631","https://openalex.org/W2088494800","https://openalex.org/W2099206288","https://openalex.org/W2099249565","https://openalex.org/W2105423509","https://openalex.org/W2107277218","https://openalex.org/W2108244474","https://openalex.org/W2110885661","https://openalex.org/W2114570899","https://openalex.org/W2138581811","https://openalex.org/W2139997876","https://openalex.org/W2145684092","https://openalex.org/W2149548143","https://openalex.org/W2156667412","https://openalex.org/W2164578725","https://openalex.org/W2165178639"],"related_works":["https://openalex.org/W2051487156","https://openalex.org/W1585007175","https://openalex.org/W2073681303","https://openalex.org/W2382521049","https://openalex.org/W2144385241","https://openalex.org/W2317200988","https://openalex.org/W4253593777","https://openalex.org/W2951497643","https://openalex.org/W2380321258","https://openalex.org/W2114530358"],"abstract_inverted_index":{"A":[0],"common":[1],"method":[2,27,56,61,93,119,126,137],"for":[3,45,96,138],"calculating":[4],"results":[5],"from":[6,51,58,141],"qPCR":[7,52,86,97,142],"experiments":[8,98],"is":[9,120],"the":[10,16,25,42,59,67,79,91,117,124,135],"comparative":[11],"Ct":[12,70],"method,":[13,41,44],"also":[14,121],"called":[15],"2(-\u0394\u0394Ct)":[17,26,60,136],"method.":[18],"However,":[19],"several":[20],"assumptions":[21],"are":[22,32,94],"included":[23],"in":[24,84,114],"and":[28,48,101,131],"standard":[29,108],"statistical":[30,49],"analyses":[31],"not":[33],"directly":[34],"applicable.":[35],"Here,":[36],"we":[37],"describe":[38],"a":[39,64,85,128],"different":[40],"X(0)":[43,55,75,92,118,125],"result":[46,139],"calculations":[47,115,140],"analysis":[50],"experiments.":[53],"The":[54],"differs":[57],"by":[62,90,116],"introducing":[63],"conversion":[65],"of":[66,81,111],"exponentially":[68],"related":[69,74],"values":[71],"into":[72],"linearly":[73],"values,":[76],"which":[77],"represent":[78],"amount":[80],"starting":[82],"material":[83],"experiment.":[87],"Results":[88],"calculated":[89],"illustrated":[95],"with":[99],"technical":[100],"biological":[102],"replicates,":[103],"including":[104],"procedures":[105],"to":[106,134],"calculate":[107],"deviations.":[109],"Incorporation":[110],"primer":[112],"efficiencies":[113],"described.":[122],"Altogether,":[123],"constitutes":[127],"very":[129],"simple":[130],"accurate":[132],"alternative":[133],"data.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-04-23T09:07:50.710637","created_date":"2016-06-24T00:00:00"}
