{"id":"https://openalex.org/W2131443816","doi":"https://doi.org/10.1142/s0219720010004756","title":"UNDERSTANDING DISTAL TRANSCRIPTIONAL REGULATION FROM SEQUENCE, EXPRESSION AND INTERACTOME PERSPECTIVES","display_name":"UNDERSTANDING DISTAL TRANSCRIPTIONAL REGULATION FROM SEQUENCE, EXPRESSION AND INTERACTOME PERSPECTIVES","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2131443816","doi":"https://doi.org/10.1142/s0219720010004756","mag":"2131443816","pmid":"https://pubmed.ncbi.nlm.nih.gov/20401945"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720010004756","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720010004756","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082923675","display_name":"Arvind Rao","orcid":"https://orcid.org/0000-0002-9613-426X"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"ARVIND RAO","raw_affiliation_strings":["Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA"],"affiliations":[{"raw_affiliation_string":"Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111548295","display_name":"David J. States","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID J. STATES","raw_affiliation_strings":["Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA"],"affiliations":[{"raw_affiliation_string":"Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077692655","display_name":"Alfred O. Hero","orcid":"https://orcid.org/0000-0002-2531-9670"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ALFRED O. HERO","raw_affiliation_strings":["Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA"],"affiliations":[{"raw_affiliation_string":"Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024115870","display_name":"James Douglas Engel","orcid":"https://orcid.org/0000-0001-9593-1825"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAMES DOUGLAS ENGEL","raw_affiliation_strings":["Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA","Samuel and Jean Frankel Cardiovascular Center"],"affiliations":[{"raw_affiliation_string":"Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Samuel and Jean Frankel Cardiovascular Center","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082923675"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.1355,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55070945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"08","issue":"02","first_page":"219","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.8542479276657104},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.7145408987998962},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6626738905906677},{"id":"https://openalex.org/keywords/regulatory-sequence","display_name":"Regulatory sequence","score":0.611192524433136},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.5999816656112671},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5125226974487305},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4894043505191803},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.45246222615242004},{"id":"https://openalex.org/keywords/dna-binding-site","display_name":"DNA binding site","score":0.43761107325553894},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.43544596433639526},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.43326547741889954},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.4208306074142456},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.390145868062973}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8542479276657104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7145408987998962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6626738905906677},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.611192524433136},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.5999816656112671},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5125226974487305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4894043505191803},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.45246222615242004},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.43761107325553894},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.43544596433639526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43326547741889954},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4208306074142456},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.390145868062973}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1142/s0219720010004756","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720010004756","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:20401945","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20401945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.190.241","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.190.241","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.eecs.umich.edu/%7Ehero/Preprints/rao_JBCB10.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W72967156","https://openalex.org/W273955616","https://openalex.org/W1965755380","https://openalex.org/W1969770714","https://openalex.org/W1974074916","https://openalex.org/W1988554428","https://openalex.org/W1988871238","https://openalex.org/W1996760543","https://openalex.org/W2008083733","https://openalex.org/W2008205503","https://openalex.org/W2031197334","https://openalex.org/W2041973176","https://openalex.org/W2060392690","https://openalex.org/W2095825597","https://openalex.org/W2100352482","https://openalex.org/W2102756316","https://openalex.org/W2106848313","https://openalex.org/W2112616936","https://openalex.org/W2113648023","https://openalex.org/W2115836056","https://openalex.org/W2121400095","https://openalex.org/W2136316164","https://openalex.org/W2136850043","https://openalex.org/W2143508168","https://openalex.org/W2144656637","https://openalex.org/W2145144631","https://openalex.org/W2157076973","https://openalex.org/W2157107511","https://openalex.org/W2161643164","https://openalex.org/W2163296115","https://openalex.org/W2164310618","https://openalex.org/W2164568552","https://openalex.org/W2165884762","https://openalex.org/W2167057061","https://openalex.org/W2168602111","https://openalex.org/W2169056802","https://openalex.org/W2314263063","https://openalex.org/W2911964244","https://openalex.org/W3099289621","https://openalex.org/W4253200202"],"related_works":["https://openalex.org/W4221130891","https://openalex.org/W2028706937","https://openalex.org/W2070964166","https://openalex.org/W2167063030","https://openalex.org/W2615895636","https://openalex.org/W2050359948","https://openalex.org/W2688223077","https://openalex.org/W2134434282","https://openalex.org/W3037778845","https://openalex.org/W2071637061"],"abstract_inverted_index":{"Gene":[0],"regulation":[1],"in":[2,21,108,147,178,184],"eukaryotes":[3],"involves":[4],"a":[5,39,58,135],"complex":[6,41],"interplay":[7],"between":[8],"the":[9,70,81,89,109,116,171,185,193],"proximal":[10,163],"promoter":[11,194],"and":[12,32,42,86,164,169],"distal":[13],"genomic":[14,128],"elements":[15,37],"(such":[16],"as":[17],"enhancers)":[18],"which":[19],"work":[20,149],"concert":[22],"to":[23,113,195],"drive":[24],"precise":[25],"spatio-temporal":[26],"gene":[27,35,59],"expression.":[28,199],"The":[29,45,145],"experimental":[30],"localization":[31,76],"characterization":[33],"of":[34,48,57,69,83,91,118,173],"regulatory":[36,49,167,188],"is":[38,60,80,104],"very":[40],"resource-intensive":[43],"process.":[44],"computational":[46,66,110],"identification":[47],"regions":[50,168],"that":[51,137,157,190],"confer":[52],"spatiotemporally":[53],"specific":[54],"tissue-restricted":[55],"expression":[56],"thus":[61],"an":[62,105],"important":[63],"challenge":[64],"for":[65,74,141,187],"biology.":[67],"One":[68],"most":[71],"popular":[72],"strategies":[73],"enhancer":[75,119,143],"from":[77,121,152],"DNA":[78],"sequence":[79,100,122],"use":[82,90],"conservation-based":[84],"prefiltering":[85],"more":[87],"recently,":[88],"canonical":[92],"(transcription":[93],"factor":[94],"motifs)":[95],"or":[96],"de":[97],"novo":[98],"tissue-specific":[99],"motifs.":[101],"However,":[102],"there":[103],"ongoing":[106],"effort":[107],"biology":[111],"community":[112],"further":[114],"improve":[115],"fidelity":[117],"predictions":[120],"data":[123],"by":[124],"integrating":[125],"other,":[126],"complementary":[127],"modalities.":[129],"In":[130],"this":[131,148],"work,":[132],"we":[133],"propose":[134],"framework":[136],"complements":[138],"existing":[139],"methodologies":[140],"prospective":[142],"identification.":[144],"methods":[146],"are":[150],"derived":[151],"two":[153],"key":[154],"insights:":[155],"(i)":[156],"chromatin":[158],"modification":[159],"signatures":[160],"can":[161],"discriminate":[162],"distally":[165],"located":[166],"(ii)":[170],"notion":[172],"promoter-enhancer":[174],"cross-talk":[175],"(as":[176],"assayed":[177],"3C/5C":[179],"experiments)":[180],"might":[181],"have":[182],"implications":[183],"search":[186],"sequences":[189],"co-operate":[191],"with":[192],"yield":[196],"tissue-restricted,":[197],"gene-specific":[198]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
