{"id":"https://openalex.org/W1991791390","doi":"https://doi.org/10.1142/s0219720010004690","title":"FLEXIBILITY AND MOBILITY IN MESOPHILIC AND THERMOPHILIC HOMOLOGOUS PROTEINS FROM MOLECULAR DYNAMICS AND FOLDUNFOLD METHOD","display_name":"FLEXIBILITY AND MOBILITY IN MESOPHILIC AND THERMOPHILIC HOMOLOGOUS PROTEINS FROM MOLECULAR DYNAMICS AND FOLDUNFOLD METHOD","publication_year":2010,"publication_date":"2010-03-16","ids":{"openalex":"https://openalex.org/W1991791390","doi":"https://doi.org/10.1142/s0219720010004690","mag":"1991791390","pmid":"https://pubmed.ncbi.nlm.nih.gov/20556851"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720010004690","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720010004690","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038436171","display_name":"Tatyana Mamonova","orcid":"https://orcid.org/0000-0002-6324-0330"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"TATYANA B. MAMONOVA","raw_affiliation_strings":["Chemistry Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057441595","display_name":"Anna V. Glyakina","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159227","display_name":"Institute of Mathematical Problems of Biology","ror":"https://ror.org/04xtpdj18","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210124601","https://openalex.org/I4210159227"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"ANNA V. GLYAKINA","raw_affiliation_strings":["Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Institutskaya str., 4, Pushchino, Moscow Region, 142290, Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Institutskaya str., 4, Pushchino, Moscow Region, 142290, Russia","institution_ids":["https://openalex.org/I4210159227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022450476","display_name":"Maria G. Kurnikova","orcid":"https://orcid.org/0000-0002-8010-8374"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARIA G. KURNIKOVA","raw_affiliation_strings":["Chemistry Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023828983","display_name":"Oxana V. Galzitskaya","orcid":"https://orcid.org/0000-0002-3962-1520"},"institutions":[{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"OXANA V. GALZITSKAYA","raw_affiliation_strings":["Institute of Protein Research, Russian Academy of Sciences, Institutskaya str., 4, Pushchino, Moscow Region, 142290, Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Protein Research, Russian Academy of Sciences, Institutskaya str., 4, Pushchino, Moscow Region, 142290, Russia","institution_ids":["https://openalex.org/I4210137602"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038436171"],"corresponding_institution_ids":["https://openalex.org/I74973139"],"apc_list":null,"apc_paid":null,"fwci":0.6609,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.67426258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"08","issue":"03","first_page":"377","last_page":"394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermophile","display_name":"Thermophile","score":0.6743910908699036},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.6406922340393066},{"id":"https://openalex.org/keywords/mesophile","display_name":"Mesophile","score":0.615515410900116},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.6139616966247559},{"id":"https://openalex.org/keywords/globular-protein","display_name":"Globular protein","score":0.6057564616203308},{"id":"https://openalex.org/keywords/rigidity","display_name":"Rigidity (electromagnetism)","score":0.5786083936691284},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5438211560249329},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.5145313143730164},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.5073649287223816},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5071027278900146},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.49118277430534363},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36266738176345825},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34930187463760376},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32980453968048096},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.2847917973995209},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2685767412185669},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2331739366054535},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22933223843574524},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.20623183250427246},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17723119258880615},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1157609224319458}],"concepts":[{"id":"https://openalex.org/C27911776","wikidata":"https://www.wikidata.org/wiki/Q834023","display_name":"Thermophile","level":3,"score":0.6743910908699036},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6406922340393066},{"id":"https://openalex.org/C63223902","wikidata":"https://www.wikidata.org/wiki/Q669652","display_name":"Mesophile","level":3,"score":0.615515410900116},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.6139616966247559},{"id":"https://openalex.org/C105168689","wikidata":"https://www.wikidata.org/wiki/Q901969","display_name":"Globular protein","level":2,"score":0.6057564616203308},{"id":"https://openalex.org/C160343418","wikidata":"https://www.wikidata.org/wiki/Q185256","display_name":"Rigidity (electromagnetism)","level":2,"score":0.5786083936691284},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5438211560249329},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5145313143730164},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5073649287223816},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5071027278900146},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.49118277430534363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36266738176345825},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34930187463760376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32980453968048096},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.2847917973995209},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2685767412185669},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2331739366054535},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22933223843574524},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.20623183250427246},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17723119258880615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1157609224319458},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720010004690","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720010004690","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:20556851","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20556851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1586022877","https://openalex.org/W1972944746","https://openalex.org/W1976272154","https://openalex.org/W1976299470","https://openalex.org/W1987834288","https://openalex.org/W1991193821","https://openalex.org/W1997477098","https://openalex.org/W2006192061","https://openalex.org/W2008708467","https://openalex.org/W2013888408","https://openalex.org/W2019004327","https://openalex.org/W2035266068","https://openalex.org/W2055141456","https://openalex.org/W2060179829","https://openalex.org/W2070496155","https://openalex.org/W2078067526","https://openalex.org/W2085277871","https://openalex.org/W2087094770","https://openalex.org/W2092485312","https://openalex.org/W2093547815","https://openalex.org/W2098598989","https://openalex.org/W2098963615","https://openalex.org/W2100250556","https://openalex.org/W2101481219","https://openalex.org/W2102845147","https://openalex.org/W2122199548","https://openalex.org/W2126303237","https://openalex.org/W2134521167","https://openalex.org/W2137496915","https://openalex.org/W2152744362","https://openalex.org/W2153195964","https://openalex.org/W2154820180","https://openalex.org/W2163627794","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2439525197","https://openalex.org/W3046261807","https://openalex.org/W2522404978","https://openalex.org/W2123989420","https://openalex.org/W4235509827","https://openalex.org/W2203541977","https://openalex.org/W1970617146","https://openalex.org/W2007616346","https://openalex.org/W2388454439","https://openalex.org/W352816361"],"abstract_inverted_index":{"To":[0],"function":[1],"properly":[2],"protein":[3,16,25],"molecules":[4],"require":[5],"both":[6,164],"flexibility":[7,192],"and":[8,12,47,72,101,193],"rigidity,":[9],"therefore":[10],"fast":[11],"accurate":[13],"prediction":[14],"of":[15,20,43,78,80,86,93,109,113,135,151,155,182,189,216],"rigidity/flexibility":[17],"is":[18,185],"one":[19],"the":[21,76,107,147],"important":[22],"problems":[23],"in":[24,39,53,83,106,166,170,213],"science.":[26],"In":[27,196],"this":[28,54,167],"work":[29,168],"we":[30],"used":[31],"two":[32],"theoretical":[33],"approaches":[34],"to":[35,58,103],"determine":[36],"flexible":[37,203,209],"regions":[38,161],"four":[40,60],"homologous":[41],"pairs":[42,51],"proteins":[44,136,200,215],"from":[45],"thermophilic":[46],"mesophilic":[48,206,214],"organisms.":[49],"Protein":[50],"chosen":[52],"study":[55],"were":[56,169,201,211],"selected":[57],"represent":[59],"typical":[61],"folding":[62],"classes.":[63,218],"Our":[64],"first":[65],"approach,":[66],"FoldUnfold,":[67],"uses":[68,119],"amino":[69,81],"acid":[70],"sequence":[71],"statistical":[73],"information":[74],"on":[75],"density":[77],"contacts":[79],"acids":[82],"tertiary":[84],"structures":[85],"known":[87,138],"globular":[88],"proteins.":[89],"The":[90,116],"main":[91],"advantages":[92],"such":[94],"knowledge-based":[95],"methodology":[96],"are":[97,143,146],"its":[98,190],"computational":[99],"speed":[100],"ability":[102],"make":[104],"predictions":[105],"absence":[108],"three-dimensional":[110],"(3D)":[111],"structure":[112],"a":[114,120,183],"protein.":[115],"second":[117],"approach":[118],"graph":[121],"theory-based":[122],"rigid":[123],"cluster":[124],"decomposition":[125],"termed":[126],"FIRST,":[127],"applied":[128],"together":[129],"with":[130,137,173],"Molecular":[131],"Dynamics":[132],"(MD)":[133],"simulations":[134,142,198],"structure.":[139],"While":[140],"MD":[141],"time-consuming,":[144],"they":[145],"most":[148],"direct":[149],"way":[150],"studying":[152],"physical":[153],"properties":[154],"proteins,":[156],"including":[157],"their":[158,205],"rigidity/flexibility.":[159],"Flexible":[160],"predicted":[162],"by":[163],"methods":[165],"good":[171],"agreement":[172],"each":[174],"other.":[175],"We":[176],"also":[177],"showed":[178],"that":[179],"high":[180,191],"mobility":[181],"site":[184],"not":[186],"necessarily":[187],"indicative":[188],"vice":[194],"versa.":[195],"our":[197],"thermophile":[199],"less":[202],"than":[204],"homologues.":[207],"Longer":[208],"loops":[210],"found":[212],"all":[217]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}