{"id":"https://openalex.org/W2067721032","doi":"https://doi.org/10.1142/s0219720007003120","title":"A STRUCTURAL BIOINFORMATICS APPROACH TO THE ANALYSIS OF NONSYNONYMOUS SINGLE NUCLEOTIDE POLYMORPHISMS (nsSNPs) AND THEIR RELATION TO DISEASE","display_name":"A STRUCTURAL BIOINFORMATICS APPROACH TO THE ANALYSIS OF NONSYNONYMOUS SINGLE NUCLEOTIDE POLYMORPHISMS (nsSNPs) AND THEIR RELATION TO DISEASE","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2067721032","doi":"https://doi.org/10.1142/s0219720007003120","mag":"2067721032","pmid":"https://pubmed.ncbi.nlm.nih.gov/18172930"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720007003120","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720007003120","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047031531","display_name":"Catherine L. Worth","orcid":"https://orcid.org/0000-0002-1796-9606"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"CATHERINE L. WORTH","raw_affiliation_strings":["Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","Biocomputing Group, Department of Biochemistry, University of Cambridge, Cambridge, UK. catherine@cryst.bioc.cam.ac.uk"],"affiliations":[{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, Cambridge, UK. catherine@cryst.bioc.cam.ac.uk","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008865110","display_name":"G. Richard Bickerton","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. RICHARD J. BICKERTON","raw_affiliation_strings":["Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK"],"affiliations":[{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059281150","display_name":"Adrian Schreyer","orcid":"https://orcid.org/0000-0001-5270-3742"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"ADRIAN SCHREYER","raw_affiliation_strings":["Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK"],"affiliations":[{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109390398","display_name":"Julia Forman","orcid":"https://orcid.org/0000-0002-3485-1327"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JULIA R. FORMAN","raw_affiliation_strings":["Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK"],"affiliations":[{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110265931","display_name":"Tammy M. K. Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"TAMMY M. K. CHENG","raw_affiliation_strings":["Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK"],"affiliations":[{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102817477","display_name":"Semin Lee","orcid":"https://orcid.org/0000-0002-9015-6046"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SEMIN LEE","raw_affiliation_strings":["Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK"],"affiliations":[{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057332623","display_name":"Sungsam Gong","orcid":"https://orcid.org/0000-0001-5796-4423"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SUNGSAM GONG","raw_affiliation_strings":["Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK"],"affiliations":[{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078733447","display_name":"David F. Burke","orcid":"https://orcid.org/0000-0001-8830-3951"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"DAVID F. BURKE","raw_affiliation_strings":["Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK","Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ,UK"],"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ,UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001029093","display_name":"Tom L. Blundell","orcid":"https://orcid.org/0000-0002-2708-8992"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"TOM. L. BLUNDELL","raw_affiliation_strings":["Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK"],"affiliations":[{"raw_affiliation_string":"Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5047031531"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":3.2264,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.92425136,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"05","issue":"06","first_page":"1297","last_page":"1318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsynonymous-substitution","display_name":"Nonsynonymous substitution","score":0.9061025381088257},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6706185936927795},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6029751300811768},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5338431596755981},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4949001669883728},{"id":"https://openalex.org/keywords/dbsnp","display_name":"dbSNP","score":0.4846358895301819},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.4621798098087311},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.4389714300632477},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.43115049600601196},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.41763073205947876},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.4111485183238983},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3911667764186859},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3463370203971863},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.2367314100265503},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.19629564881324768},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16730087995529175},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.0785554051399231}],"concepts":[{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.9061025381088257},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6706185936927795},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6029751300811768},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5338431596755981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4949001669883728},{"id":"https://openalex.org/C35794970","wikidata":"https://www.wikidata.org/wiki/Q5243761","display_name":"dbSNP","level":5,"score":0.4846358895301819},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.4621798098087311},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4389714300632477},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43115049600601196},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.41763073205947876},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4111485183238983},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3911667764186859},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3463370203971863},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2367314100265503},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.19629564881324768},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16730087995529175},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0785554051399231},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1142/s0219720007003120","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720007003120","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:18172930","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18172930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:edoc.mdc-berlin.de:17451","is_oa":false,"landing_page_url":"https://edoc.mdc-berlin.de/17451/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:scholarworks.unist.ac.kr:201301/18897","is_oa":false,"landing_page_url":"https://scholarworks.unist.ac.kr/handle/201301/18897","pdf_url":null,"source":{"id":"https://openalex.org/S4306401118","display_name":"Scholarworks@UNIST (Ulsan National Institute of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I48566637","host_organization_name":"Ulsan National Institute of Science and Technology","host_organization_lineage":["https://openalex.org/I48566637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"ARTICLE"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320241","display_name":"Academy of Medical Sciences","ror":"https://ror.org/00c489v88"},{"id":"https://openalex.org/F4320321846","display_name":"Cambridge Overseas Trust","ror":"https://ror.org/05sprqy15"},{"id":"https://openalex.org/F4320321848","display_name":"Cambridge Trust","ror":"https://ror.org/05sprqy15"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1541967700","https://openalex.org/W1585634379","https://openalex.org/W1842444176","https://openalex.org/W1851389060","https://openalex.org/W1966844407","https://openalex.org/W1971361647","https://openalex.org/W1972682479","https://openalex.org/W1975580333","https://openalex.org/W1977845138","https://openalex.org/W1979843610","https://openalex.org/W1980112545","https://openalex.org/W1984431560","https://openalex.org/W1990139289","https://openalex.org/W1996690349","https://openalex.org/W2003603552","https://openalex.org/W2004178884","https://openalex.org/W2004228538","https://openalex.org/W2004306990","https://openalex.org/W2008708467","https://openalex.org/W2016147963","https://openalex.org/W2016572810","https://openalex.org/W2019574765","https://openalex.org/W2033729776","https://openalex.org/W2038936167","https://openalex.org/W2043714862","https://openalex.org/W2049349724","https://openalex.org/W2055222883","https://openalex.org/W2063274819","https://openalex.org/W2065283382","https://openalex.org/W2065385636","https://openalex.org/W2079306416","https://openalex.org/W2083624153","https://openalex.org/W2085277871","https://openalex.org/W2086719212","https://openalex.org/W2090304431","https://openalex.org/W2090699441","https://openalex.org/W2091488105","https://openalex.org/W2092387745","https://openalex.org/W2096525273","https://openalex.org/W2097794038","https://openalex.org/W2098322708","https://openalex.org/W2107305018","https://openalex.org/W2109372707","https://openalex.org/W2111483871","https://openalex.org/W2113710405","https://openalex.org/W2114370367","https://openalex.org/W2119412782","https://openalex.org/W2121211053","https://openalex.org/W2121519777","https://openalex.org/W2122732537","https://openalex.org/W2123105772","https://openalex.org/W2123972677","https://openalex.org/W2128037044","https://openalex.org/W2130090934","https://openalex.org/W2130479394","https://openalex.org/W2132992030","https://openalex.org/W2135749526","https://openalex.org/W2136513422","https://openalex.org/W2141481588","https://openalex.org/W2142209403","https://openalex.org/W2143173841","https://openalex.org/W2145644903","https://openalex.org/W2151831732","https://openalex.org/W2152279845","https://openalex.org/W2152949473","https://openalex.org/W2153481451","https://openalex.org/W2156494890","https://openalex.org/W2159482845","https://openalex.org/W2160938004","https://openalex.org/W2161062388","https://openalex.org/W2163721943","https://openalex.org/W2164004777","https://openalex.org/W2164437046","https://openalex.org/W2165181282","https://openalex.org/W2165739018","https://openalex.org/W2172460140","https://openalex.org/W3139891502","https://openalex.org/W4210241463","https://openalex.org/W4211083314","https://openalex.org/W4245543257","https://openalex.org/W4249030130"],"related_works":["https://openalex.org/W2029292949","https://openalex.org/W2031716005","https://openalex.org/W3028974969","https://openalex.org/W2978155750","https://openalex.org/W45489710","https://openalex.org/W4243015022","https://openalex.org/W2992895139","https://openalex.org/W2061407956","https://openalex.org/W2030069078","https://openalex.org/W2145418365"],"abstract_inverted_index":{"The":[0,92],"prediction":[1,53],"of":[2,5,24,34,57,60,77,85,128,151,158],"the":[3,21,32,55,58,75,83,125,142,149],"effects":[4,59],"nonsynonymous":[6],"single":[7],"nucleotide":[8],"polymorphisms":[9],"(nsSNPs)":[10],"on":[11,15,20,74,132],"function":[12],"depends":[13],"critically":[14],"exploiting":[16],"all":[17],"information":[18,64],"available":[19],"three-dimensional":[22],"structures":[23],"proteins.":[25],"We":[26,136],"describe":[27,137],"software":[28],"and":[29,54,101,109,119,134,146,148,161],"databases":[30],"for":[31,140],"analysis":[33,56],"nsSNPs":[35],"that":[36,70],"allow":[37],"a":[38],"user":[39],"to":[40,44,46,48,79,106,110,123],"move":[41],"from":[42,72,82],"SNP":[43],"sequence":[45,78],"structure":[47,52,80,133,160],"function.":[49],"In":[50],"both":[51],"nsSNPs,":[61],"we":[62],"exploit":[63],"about":[65],"protein":[66],"evolution,":[67],"in":[68,89,95],"particular,":[69],"derived":[71],"investigations":[73],"relation":[76],"gained":[81],"study":[84],"amino":[86,129],"acid":[87,130],"substitutions":[88,131],"divergent":[90],"evolution.":[91],"techniques":[93],"developed":[94],"our":[96,138,153],"laboratory":[97],"have":[98],"allowed":[99],"fast":[100],"automated":[102],"sequence-structure":[103],"homology":[104],"recognition":[105],"identify":[107],"templates":[108],"perform":[111],"comparative":[112],"modeling;":[113],"as":[114,116],"well":[115],"simple,":[117],"robust,":[118],"generally":[120],"applicable":[121],"algorithms":[122],"assess":[124],"likely":[126],"impact":[127],"interactions.":[135],"strategy":[139],"approaching":[141],"relationship":[143],"between":[144],"SNPs":[145],"disease,":[147],"results":[150],"benchmarking":[152],"approach":[154],"--":[155],"human":[156],"proteins":[157],"known":[159],"recognized":[162],"mutation.":[163]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
