{"id":"https://openalex.org/W2065681326","doi":"https://doi.org/10.1142/s0219720007002849","title":"MATHEMATICAL MODEL FOR SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICATION IN CELL CULTURE","display_name":"MATHEMATICAL MODEL FOR SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICATION IN CELL CULTURE","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W2065681326","doi":"https://doi.org/10.1142/s0219720007002849","mag":"2065681326","pmid":"https://pubmed.ncbi.nlm.nih.gov/17636864"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720007002849","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720007002849","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006675531","display_name":"E. L. Mishchenko","orcid":null},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"ELENA L. MISHCHENKO","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210127387","https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032882113","display_name":"KIRILL D. BEZMATERNYKH","orcid":null},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"KIRILL D. BEZMATERNYKH","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210127387","https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091223474","display_name":"\u0412. \u0410. \u041b\u0438\u0445\u043e\u0448\u0432\u0430\u0439","orcid":"https://orcid.org/0000-0001-9440-074X"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"VITALY A. LIKHOSHVAI","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210127387","https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006116532","display_name":"Alexander V. Ratushny","orcid":"https://orcid.org/0000-0002-1701-4084"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"ALEXANDER V. RATUSHNY","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210127387","https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056460726","display_name":"\u0422. \u041c. \u0425\u043b\u0435\u0431\u043e\u0434\u0430\u0440\u043e\u0432\u0430","orcid":null},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"TAMARA M. KHLEBODAROVA","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210127387","https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023998465","display_name":"NATALIA YU. SOURNINA","orcid":null},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"NATALIA YU. SOURNINA","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210127387","https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014655081","display_name":"\u0412. \u0410. \u0418\u0432\u0430\u043d\u0438\u0441\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-1859-4631"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"VLADIMIR A. IVANISENKO","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210127387","https://openalex.org/I4210116466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038764591","display_name":"\u041d. \u0410. \u041a\u043e\u043b\u0447\u0430\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0001-6800-8787"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"NIKOLAI A. KOLCHANOV","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Lavrentieva Ave., 10, Novosibirsk State University, Pirogova Ave., Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210127387","https://openalex.org/I4210116466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3056,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.59071688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"05","issue":"02b","first_page":"593","last_page":"609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subgenomic-mrna","display_name":"Subgenomic mRNA","score":0.8230814933776855},{"id":"https://openalex.org/keywords/replicon","display_name":"Replicon","score":0.7845857739448547},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.7260492444038391},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.717178463935852},{"id":"https://openalex.org/keywords/ns2-3-protease","display_name":"NS2-3 protease","score":0.658720076084137},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.632135808467865},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.601372241973877},{"id":"https://openalex.org/keywords/ns3","display_name":"NS3","score":0.5572535991668701},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"Hepatitis C virus","score":0.512701153755188},{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.47416818141937256},{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.45891910791397095},{"id":"https://openalex.org/keywords/protease-inhibitor","display_name":"Protease inhibitor (pharmacology)","score":0.4499264657497406},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.4457990825176239},{"id":"https://openalex.org/keywords/rna-virus","display_name":"RNA virus","score":0.431461364030838},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.4191688895225525},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.3042204976081848},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.21829548478126526},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.19820600748062134},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1749604046344757},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1530832052230835},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1031147837638855}],"concepts":[{"id":"https://openalex.org/C189819185","wikidata":"https://www.wikidata.org/wiki/Q384283","display_name":"Subgenomic mRNA","level":4,"score":0.8230814933776855},{"id":"https://openalex.org/C18103114","wikidata":"https://www.wikidata.org/wiki/Q1720369","display_name":"Replicon","level":4,"score":0.7845857739448547},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.7260492444038391},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.717178463935852},{"id":"https://openalex.org/C83100098","wikidata":"https://www.wikidata.org/wiki/Q106297070","display_name":"NS2-3 protease","level":4,"score":0.658720076084137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.632135808467865},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.601372241973877},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.5572535991668701},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.512701153755188},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.47416818141937256},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.45891910791397095},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4499264657497406},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4457990825176239},{"id":"https://openalex.org/C2779174946","wikidata":"https://www.wikidata.org/wiki/Q751911","display_name":"RNA virus","level":4,"score":0.431461364030838},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4191688895225525},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3042204976081848},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.21829548478126526},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19820600748062134},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1749604046344757},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1530832052230835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1031147837638855},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012093","descriptor_name":"Replicon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012093","descriptor_name":"Replicon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012093","descriptor_name":"Replicon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720007002849","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720007002849","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:17636864","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17636864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6200000047683716,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1559154670","https://openalex.org/W1763230925","https://openalex.org/W1847011379","https://openalex.org/W1986308869","https://openalex.org/W1997843363","https://openalex.org/W2004440658","https://openalex.org/W2015336471","https://openalex.org/W2021451720","https://openalex.org/W2063072523","https://openalex.org/W2068128206","https://openalex.org/W2092333889","https://openalex.org/W2094737728","https://openalex.org/W2097913517","https://openalex.org/W2112354998","https://openalex.org/W2113280507","https://openalex.org/W2119319706","https://openalex.org/W2126153046","https://openalex.org/W2128983623","https://openalex.org/W2132879836","https://openalex.org/W2136523601","https://openalex.org/W2137177799","https://openalex.org/W2138056007","https://openalex.org/W2144407007","https://openalex.org/W2147885904","https://openalex.org/W2151898297","https://openalex.org/W2155938469","https://openalex.org/W2161845487","https://openalex.org/W2415522248"],"related_works":["https://openalex.org/W2062405322","https://openalex.org/W2380538049","https://openalex.org/W3144489528","https://openalex.org/W2105770276","https://openalex.org/W2010945216","https://openalex.org/W1988989075","https://openalex.org/W2067819264","https://openalex.org/W1974733477","https://openalex.org/W2415719708","https://openalex.org/W1993034267"],"abstract_inverted_index":{"A":[0],"mathematical":[1,160],"model":[2,161],"for":[3,37,66,167],"suppression":[4],"of":[5,20,43,52,69,72,77,98,103,107,128,150,170,173],"the":[6,18,31,38,41,47,50,53,60,64,67,70,88,95,104,114,126,129,135,140,148,152,168,171,177],"hepatitis":[7],"C":[8],"virus":[9],"RNA":[10,45,79,145],"replicon":[11],"replication":[12,76,96,146],"in":[13,17,40,46,49,147],"Huh-7":[14],"cell":[15,48],"culture":[16],"presence":[19,51,149],"potential":[21,73,174],"drugs":[22,74,90,175],"was":[23,26,85,119,123],"built.":[24],"There":[25],"a":[27,165],"good":[28],"agreement":[29],"between":[30],"experimental":[32],"and":[33,80,109,116],"theoretical":[34],"kinetic":[35],"data":[36],"decrease":[39],"level":[42],"viral":[44,78,81,99,117,144],"competitive":[54],"HCV":[55,178],"NS3":[56,155],"protease":[57,156],"inhibitor.":[58],"Using":[59],"model,":[61],"we":[62],"verified":[63],"estimates":[65],"efficiency":[68,102,172],"effect":[71,142],"on":[75,113,134,143,176],"protein":[82],"processing.":[83],"It":[84,122],"demonstrated":[86],"that":[87,125],"tested":[89],"are":[91],"most":[92],"efficient":[93],"at":[94,131],"step":[97],"RNA.":[100],"The":[101,158],"combined":[105],"action":[106,127],"real":[108],"putative":[110],"inhibitors":[111],"target":[112],"host":[115,136],"proteins":[118],"also":[120],"studied.":[121],"found":[124],"inhibitor":[130],"low":[132,153],"concentrations":[133],"factors":[137],"considerably":[138],"enhances":[139],"suppressive":[141],"even":[151],"affine":[154],"inhibitors.":[157],"developed":[159],"may":[162],"serve":[163],"as":[164],"tool":[166],"evaluation":[169],"genome.":[179]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
