{"id":"https://openalex.org/W2104765182","doi":"https://doi.org/10.1142/s0219720007002837","title":"GENERALIZED HILL FUNCTION METHOD FOR MODELING MOLECULAR PROCESSES","display_name":"GENERALIZED HILL FUNCTION METHOD FOR MODELING MOLECULAR PROCESSES","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W2104765182","doi":"https://doi.org/10.1142/s0219720007002837","mag":"2104765182","pmid":"https://pubmed.ncbi.nlm.nih.gov/17636859"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720007002837","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720007002837","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108339325","display_name":"Vitali A. Likhoshvai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"VITALI LIKHOSHVAI","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035934317","display_name":"A V Ratushny","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"funder","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"ALEXANDER RATUSHNY","raw_affiliation_strings":["Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108339325"],"corresponding_institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387"],"apc_list":null,"apc_paid":null,"fwci":0.6545,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.68277116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"05","issue":"02b","first_page":"521","last_page":"531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.708503007888794},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6125482320785522},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5780823230743408},{"id":"https://openalex.org/keywords/operon","display_name":"Operon","score":0.5087609887123108},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.47604894638061523},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4624612033367157},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4392380118370056},{"id":"https://openalex.org/keywords/molecular-model","display_name":"Molecular model","score":0.43526753783226013},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.423984557390213},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.4111425280570984},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3287823796272278},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.27424338459968567},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23494669795036316},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.12094005942344666}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.708503007888794},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6125482320785522},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5780823230743408},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.5087609887123108},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47604894638061523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4624612033367157},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4392380118370056},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.43526753783226013},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.423984557390213},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4111425280570984},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3287823796272278},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27424338459968567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23494669795036316},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.12094005942344666}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720007002837","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720007002837","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:17636859","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17636859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1817368947","https://openalex.org/W1982309495","https://openalex.org/W2047546344","https://openalex.org/W2108078368","https://openalex.org/W2130151145","https://openalex.org/W2146856779","https://openalex.org/W2183509704","https://openalex.org/W2187314440","https://openalex.org/W2318277125","https://openalex.org/W2415522248","https://openalex.org/W2504688298","https://openalex.org/W2557864727","https://openalex.org/W2560692664","https://openalex.org/W3146285857","https://openalex.org/W3148991970","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1608194938","https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2572774164","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2003194288","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2944893694"],"abstract_inverted_index":{"Development":[0],"of":[1,10,15,20,23,31,39,47,55,57,62,69,95,101,108,118,126],"an":[2,7,127],"in":[3,99],"silico":[4],"cell":[5,17,43],"is":[6,92],"urgent":[8],"task":[9],"systems":[11,111],"biology.":[12],"The":[13,89],"core":[14],"this":[16,76],"should":[18,44],"consist":[19],"mathematical":[21],"models":[22,125],"intracellular":[24],"events,":[25],"including":[26],"enzymatic":[27,51,128],"reactions":[28,52],"and":[29,53,112,136],"control":[30],"gene":[32],"expression.":[33],"For":[34],"example,":[35],"the":[36,40,59,132,137],"minimal":[37],"model":[38],"E.":[41],"coli":[42],"include":[45],"description":[46],"about":[48],"one":[49],"thousand":[50],"regulation":[54,141],"expression":[56,140],"approximately":[58],"same":[60],"number":[61],"genes.":[63],"In":[64,75],"many":[65],"cases":[66],"detailed":[67,120],"mechanisms":[68],"molecular":[70,87,109],"processes":[71],"are":[72,142],"not":[73,115],"known.":[74],"study,":[77],"we":[78],"propose":[79],"a":[80,93],"generalized":[81],"Hill":[82,123],"function":[83,124],"method":[84,94],"for":[85],"modeling":[86],"events.":[88],"proposed":[90],"approach":[91],"kinetic":[96],"data":[97,103],"approximation":[98],"view":[100],"additional":[102],"on":[104],"structure":[105],"functional":[106],"features":[107],"genetic":[110],"actually":[113],"does":[114],"demand":[116],"knowledge":[117],"their":[119],"mechanisms.":[121],"Generalized":[122],"reaction":[129],"catalyzed":[130],"by":[131],"tryptophan-sensitive":[133],"3-deoxy-d-arabino-heptulosonate-7-phosphate":[134],"synthase":[135],"cydAB":[138],"operon":[139],"presented.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}