{"id":"https://openalex.org/W1999982948","doi":"https://doi.org/10.1142/s0219720006001862","title":"APPLICATION OF A GENERALIZED MWC MODEL FOR THE MATHEMATICAL SIMULATION OF METABOLIC PATHWAYS REGULATED BY ALLOSTERIC ENZYMES","display_name":"APPLICATION OF A GENERALIZED MWC MODEL FOR THE MATHEMATICAL SIMULATION OF METABOLIC PATHWAYS REGULATED BY ALLOSTERIC ENZYMES","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W1999982948","doi":"https://doi.org/10.1142/s0219720006001862","mag":"1999982948","pmid":"https://pubmed.ncbi.nlm.nih.gov/16819787"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720006001862","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720006001862","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059541172","display_name":"Tarek S. Najdi","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TAREK S. NAJDI","raw_affiliation_strings":["Institute for Genomics and Bioinformatics, Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Bioinformatics, Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087681217","display_name":"Chin\u2010Rang Yang","orcid":"https://orcid.org/0000-0002-3445-9819"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHIN-RANG YANG","raw_affiliation_strings":["Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034588960","display_name":"Bruce E. Shapiro","orcid":"https://orcid.org/0000-0003-3130-4659"},"institutions":[{"id":"https://openalex.org/I1334627681","display_name":"Jet Propulsion Laboratory","ror":"https://ror.org/027k65916","country_code":"US","type":"facility","lineage":["https://openalex.org/I122411786","https://openalex.org/I1334627681","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210118524","display_name":"Universit\u00e9 Bourgogne Franche-Comt\u00e9","ror":"https://ror.org/02dn7x778","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210118524"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"BRUCE E. SHAPIRO","raw_affiliation_strings":["Jet Propulsion Laboratory, California Institute of Technology 4800 Oak Grove Drive, Pasadena, California 91109, USA","Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California, 91109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jet Propulsion Laboratory, California Institute of Technology 4800 Oak Grove Drive, Pasadena, California 91109, USA","institution_ids":["https://openalex.org/I1334627681"]},{"raw_affiliation_string":"Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California, 91109, USA","institution_ids":["https://openalex.org/I4210118524","https://openalex.org/I1334627681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112174456","display_name":"G. Wesley Hatfield","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. WESLEY HATFIELD","raw_affiliation_strings":["Institute for Genomics and Bioinformatics, Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Bioinformatics, Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088981910","display_name":"Eric Mjolsness","orcid":"https://orcid.org/0000-0002-9085-9171"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ERIC D. MJOLSNESS","raw_affiliation_strings":["Institute for Genomics and Bioinformatics, Donald Bren School of Information and Computer Science, University of California, Irvine, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Bioinformatics, Donald Bren School of Information and Computer Science, University of California, Irvine, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9546,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.72278074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"04","issue":"02","first_page":"335","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9758999943733215,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.8581156134605408},{"id":"https://openalex.org/keywords/phosphofructokinase-2","display_name":"Phosphofructokinase 2","score":0.70931476354599},{"id":"https://openalex.org/keywords/allosteric-enzyme","display_name":"Allosteric enzyme","score":0.5927750468254089},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.5674411058425903},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.42497751116752625},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.4131728410720825},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.36735427379608154},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34377017617225647},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33462172746658325},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.18164649605751038},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17660808563232422}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8581156134605408},{"id":"https://openalex.org/C58431802","wikidata":"https://www.wikidata.org/wiki/Q420663","display_name":"Phosphofructokinase 2","level":3,"score":0.70931476354599},{"id":"https://openalex.org/C109964505","wikidata":"https://www.wikidata.org/wiki/Q3321436","display_name":"Allosteric enzyme","level":4,"score":0.5927750468254089},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5674411058425903},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.42497751116752625},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4131728410720825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36735427379608154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34377017617225647},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33462172746658325},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.18164649605751038},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17660808563232422},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001225","descriptor_name":"Aspartokinase Homoserine Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001225","descriptor_name":"Aspartokinase Homoserine Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001225","descriptor_name":"Aspartokinase Homoserine Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1142/s0219720006001862","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720006001862","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:16819787","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16819787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.121.9382","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.121.9382","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://sysbio.swmed.edu/pdf/jbcb_najdi.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.89.1138","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.89.1138","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://computableplant.ics.uci.edu/papers/GMWC06.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309999","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1525055187","https://openalex.org/W1528995211","https://openalex.org/W1582440271","https://openalex.org/W1982535624","https://openalex.org/W1998093640","https://openalex.org/W2001839663","https://openalex.org/W2003989984","https://openalex.org/W2024009600","https://openalex.org/W2036338631","https://openalex.org/W2043450929","https://openalex.org/W2044189879","https://openalex.org/W2074367710","https://openalex.org/W2100688306","https://openalex.org/W2102489535","https://openalex.org/W2109975391","https://openalex.org/W2116726967","https://openalex.org/W2117874336","https://openalex.org/W2136236617","https://openalex.org/W2170986727","https://openalex.org/W2477591259","https://openalex.org/W2915798663","https://openalex.org/W4234290109"],"related_works":["https://openalex.org/W2155567448","https://openalex.org/W2000369204","https://openalex.org/W2063399906","https://openalex.org/W2407502286","https://openalex.org/W251024706","https://openalex.org/W2174433955","https://openalex.org/W4226432793","https://openalex.org/W2047806852","https://openalex.org/W2142270568","https://openalex.org/W52797708"],"abstract_inverted_index":{"In":[0,68],"our":[1],"effort":[2],"to":[3,91],"elucidate":[4],"the":[5,9,22,48,81,109,112,125,131,136,144],"systems":[6],"biology":[7],"of":[8,51,111,127,143,146],"model":[10,19,76,86,106,123],"organism,":[11],"Escherichia":[12],"coli,":[13],"we":[14,36,71,102],"have":[15,103],"developed":[16,104],"a":[17,39,73,105,139],"mathematical":[18,49],"that":[20,43,107],"simulates":[21],"allosteric":[23,89,114],"regulation":[24,90],"for":[25,47,87,93,138],"threonine":[26],"biosynthesis":[27],"pathway":[28],"starting":[29],"from":[30],"aspartate.":[31],"To":[32],"achieve":[33],"this":[34,69],"goal,":[35],"used":[37],"kMech,":[38],"Cellerator":[40,59],"language":[41],"extension":[42],"describes":[44,108],"enzyme":[45,88,115,128],"mechanisms":[46,55],"modeling":[50],"metabolic":[52],"pathways.":[53],"These":[54],"are":[56],"converted":[57],"by":[58,66],"into":[60],"ordinary":[61],"differential":[62],"equations":[63],"(ODEs)":[64],"solvable":[65],"Mathematica.":[67],"paper,":[70],"describe":[72],"more":[74,140],"flexible":[75],"in":[77,130],"Cellerator,":[78],"which":[79,134],"generalizes":[80],"Monod,":[82],"Wyman,":[83],"Changeux":[84],"(MWC)":[85],"allow":[92],"multiple":[94],"substrate,":[95],"activator":[96],"and":[97],"inhibitor":[98],"binding":[99],"sites.":[100],"Furthermore,":[101],"behavior":[110,145],"bifunctional":[113,147],"aspartate":[116],"kinase":[117],"I-homoserine":[118],"dehydrogenase":[119],"I":[120],"(AKI-HDHI).":[121],"This":[122],"predicts":[124],"partition":[126],"activities":[129],"steady":[132],"state":[133],"paves":[135],"way":[137],"generalized":[141],"prediction":[142],"enzymes.":[148]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
