{"id":"https://openalex.org/W1995281624","doi":"https://doi.org/10.1142/s0219720005001211","title":"A THEORETICAL ANALYSIS OF THE SELECTION OF DIFFERENTIALLY EXPRESSED GENES","display_name":"A THEORETICAL ANALYSIS OF THE SELECTION OF DIFFERENTIALLY EXPRESSED GENES","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W1995281624","doi":"https://doi.org/10.1142/s0219720005001211","mag":"1995281624","pmid":"https://pubmed.ncbi.nlm.nih.gov/16108087"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720005001211","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720005001211","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112866063","display_name":"Sach Mukherjee","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SACH MUKHERJEE","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom","Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058617210","display_name":"Stephen Roberts","orcid":"https://orcid.org/0000-0002-9305-9268"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"STEPHEN J. ROBERTS","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom","Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":0.7535,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.68124042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"03","issue":"03","first_page":"627","last_page":"643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9855999946594238,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.7666726112365723},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.7004283666610718},{"id":"https://openalex.org/keywords/gene-selection","display_name":"Gene selection","score":0.5591276288032532},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5417661070823669},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5002670288085938},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43447136878967285},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43272674083709717},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.4305415153503418},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.41949397325515747},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.355033814907074},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3497034013271332},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.32047417759895325},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2992841601371765},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17952829599380493},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10170572996139526}],"concepts":[{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.7666726112365723},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.7004283666610718},{"id":"https://openalex.org/C2984324147","wikidata":"https://www.wikidata.org/wiki/Q3080021","display_name":"Gene selection","level":5,"score":0.5591276288032532},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5417661070823669},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5002670288085938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43447136878967285},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43272674083709717},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.4305415153503418},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41949397325515747},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.355033814907074},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3497034013271332},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.32047417759895325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2992841601371765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17952829599380493},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10170572996139526},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1142/s0219720005001211","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720005001211","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:16108087","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16108087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null},{"id":"pmh:oai:ora.ox.ac.uk:uuid:07576e79-aa26-44db-925c-c509c08cd80c","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:07576e79-aa26-44db-925c-c509c08cd80c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320005","display_name":"Royal Academy of Engineering","ror":"https://ror.org/0526snb40"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W175331258","https://openalex.org/W176718423","https://openalex.org/W1479884316","https://openalex.org/W1965138864","https://openalex.org/W1970156673","https://openalex.org/W1991567646","https://openalex.org/W2001697496","https://openalex.org/W2008233728","https://openalex.org/W2105793531","https://openalex.org/W2109363337","https://openalex.org/W2116811581","https://openalex.org/W2123172482","https://openalex.org/W2130494035","https://openalex.org/W2133210805","https://openalex.org/W2137807839","https://openalex.org/W2142460132","https://openalex.org/W2144227498","https://openalex.org/W2157795344","https://openalex.org/W2170778160","https://openalex.org/W3148560526","https://openalex.org/W4239029175","https://openalex.org/W4247420482","https://openalex.org/W4249495609","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W1494981348","https://openalex.org/W1570056848","https://openalex.org/W4313016600","https://openalex.org/W1492428813","https://openalex.org/W1533508595","https://openalex.org/W4246140247","https://openalex.org/W2170304139","https://openalex.org/W4299306949","https://openalex.org/W4308011238","https://openalex.org/W2544198685"],"abstract_inverted_index":{"A":[0],"great":[1],"deal":[2],"of":[3,12,70,77,93,140,148,154,161,165],"recent":[4],"research":[5],"has":[6,106],"focused":[7],"on":[8,123],"the":[9,30,75,125,138,152,159],"challenging":[10],"task":[11],"selecting":[13,79],"differentially":[14,80],"expressed":[15,81],"genes":[16,155],"from":[17],"microarray":[18],"data":[19],"(\"gene":[20],"selection\").":[21],"Numerous":[22],"gene":[23,71,141,174],"selection":[24,142,175],"algorithms":[25,40,143],"have":[26],"been":[27],"proposed":[28],"in":[29,59,73,91],"literature,":[31],"but":[32],"it":[33],"is":[34,88,99,129,168],"often":[35],"unclear":[36],"exactly":[37],"how":[38],"these":[39],"respond":[41],"to":[42,101,120,136],"conditions":[43],"like":[44],"small":[45],"sample":[46],"sizes":[47],"or":[48,111],"differing":[49],"variances.":[50],"Choosing":[51],"an":[52],"appropriate":[53],"algorithm":[54],"can":[55,114,133],"therefore":[56],"be":[57,115,134],"difficult":[58],"many":[60],"cases.":[61],"In":[62,118],"this":[63],"paper":[64],"we":[65],"propose":[66],"a":[67,84,107,145],"theoretical":[68],"analysis":[69],"selection,":[72],"which":[74,105,113],"probability":[76],"successfully":[78],"genes,":[82],"using":[83],"given":[85],"ranking":[86,103],"function,":[87],"explicitly":[89],"calculated":[90],"terms":[92],"population":[94],"parameters.":[95],"The":[96,163],"theory":[97],"developed":[98],"applicable":[100],"any":[102],"function":[104],"known":[108],"sampling":[109],"distribution,":[110],"one":[112],"approximated":[116],"analytically.":[117],"contrast":[119],"methods":[121],"based":[122],"simulation,":[124],"approach":[126,167],"presented":[127],"here":[128],"computationally":[130],"efficient":[131],"and":[132],"used":[135],"examine":[137],"behavior":[139],"under":[144],"wide":[146],"variety":[147],"conditions,":[149],"even":[150],"when":[151],"number":[153],"involved":[156],"runs":[157],"into":[158],"tens":[160],"thousands.":[162],"utility":[164],"our":[166],"illustrated":[169],"by":[170],"comparing":[171],"three":[172],"widely-used":[173],"methods.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}