{"id":"https://openalex.org/W2031173759","doi":"https://doi.org/10.1142/s0219720004000946","title":"ROBUSTNESS, STABILITY AND EFFICIENCY OF PHAGE \u03bb GENETIC SWITCH: DYNAMICAL STRUCTURE ANALYSIS","display_name":"ROBUSTNESS, STABILITY AND EFFICIENCY OF PHAGE \u03bb GENETIC SWITCH: DYNAMICAL STRUCTURE ANALYSIS","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2031173759","doi":"https://doi.org/10.1142/s0219720004000946","mag":"2031173759","pmid":"https://pubmed.ncbi.nlm.nih.gov/15617166"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720004000946","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720004000946","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045105316","display_name":"Xiaomei Zhu","orcid":"https://orcid.org/0000-0002-3674-3565"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"X.-M. ZHU","raw_affiliation_strings":["GenMath, Corp. 5525 27th Ave.N.E., Seattle, WA 98105, USA"],"affiliations":[{"raw_affiliation_string":"GenMath, Corp. 5525 27th Ave.N.E., Seattle, WA 98105, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102929467","display_name":"Lan Yin","orcid":"https://orcid.org/0000-0001-9627-3334"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. YIN","raw_affiliation_strings":["School of Physics, Peking University, Beijing 100871, PR China"],"affiliations":[{"raw_affiliation_string":"School of Physics, Peking University, Beijing 100871, PR China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085306431","display_name":"Leroy Hood","orcid":"https://orcid.org/0000-0001-7158-3678"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. HOOD","raw_affiliation_strings":["Institute for Systems Biology, 1441 N. 34 St., Seattle, WA 98103, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, 1441 N. 34 St., Seattle, WA 98103, USA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106120565","display_name":"Ping Ao","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. AO","raw_affiliation_strings":["Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045105316"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9294,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.84790737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"02","issue":"04","first_page":"785","last_page":"817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysogen","display_name":"Lysogen","score":0.7056844234466553},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6731274127960205},{"id":"https://openalex.org/keywords/saddle-point","display_name":"Saddle point","score":0.5744612216949463},{"id":"https://openalex.org/keywords/fitness-landscape","display_name":"Fitness landscape","score":0.564574658870697},{"id":"https://openalex.org/keywords/saddle","display_name":"Saddle","score":0.5042489767074585},{"id":"https://openalex.org/keywords/lambda","display_name":"Lambda","score":0.4876905679702759},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4736432135105133},{"id":"https://openalex.org/keywords/lambda-phage","display_name":"Lambda phage","score":0.43541499972343445},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.4127897322177887},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.40372779965400696},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32376420497894287},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2810196876525879},{"id":"https://openalex.org/keywords/bacteriophage","display_name":"Bacteriophage","score":0.2069973349571228},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.20116740465164185},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16191324591636658},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.14119568467140198},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.13477134704589844},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1328948736190796},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.09808388352394104}],"concepts":[{"id":"https://openalex.org/C48292096","wikidata":"https://www.wikidata.org/wiki/Q6710264","display_name":"Lysogen","level":5,"score":0.7056844234466553},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6731274127960205},{"id":"https://openalex.org/C2681867","wikidata":"https://www.wikidata.org/wiki/Q690935","display_name":"Saddle point","level":2,"score":0.5744612216949463},{"id":"https://openalex.org/C91852762","wikidata":"https://www.wikidata.org/wiki/Q3307742","display_name":"Fitness landscape","level":3,"score":0.564574658870697},{"id":"https://openalex.org/C2777127463","wikidata":"https://www.wikidata.org/wiki/Q10862618","display_name":"Saddle","level":2,"score":0.5042489767074585},{"id":"https://openalex.org/C2778113609","wikidata":"https://www.wikidata.org/wiki/Q10897","display_name":"Lambda","level":2,"score":0.4876905679702759},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4736432135105133},{"id":"https://openalex.org/C2781135666","wikidata":"https://www.wikidata.org/wiki/Q615868","display_name":"Lambda phage","level":5,"score":0.43541499972343445},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4127897322177887},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.40372779965400696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32376420497894287},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2810196876525879},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.2069973349571228},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.20116740465164185},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16191324591636658},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.14119568467140198},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.13477134704589844},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1328948736190796},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.09808388352394104},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008242","descriptor_name":"Lysogeny","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008242","descriptor_name":"Lysogeny","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008242","descriptor_name":"Lysogeny","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720004000946","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720004000946","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:15617166","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15617166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","score":0.5600000023841858,"display_name":"Responsible consumption and production"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W328825372","https://openalex.org/W400972389","https://openalex.org/W1486183464","https://openalex.org/W1509938542","https://openalex.org/W1535401479","https://openalex.org/W1564715836","https://openalex.org/W1593308984","https://openalex.org/W1623155147","https://openalex.org/W1946177469","https://openalex.org/W1983541651","https://openalex.org/W1986717140","https://openalex.org/W1988038289","https://openalex.org/W1994926732","https://openalex.org/W2006496606","https://openalex.org/W2009875303","https://openalex.org/W2018507982","https://openalex.org/W2019424210","https://openalex.org/W2021010454","https://openalex.org/W2021059161","https://openalex.org/W2023002165","https://openalex.org/W2031369606","https://openalex.org/W2031563831","https://openalex.org/W2057276826","https://openalex.org/W2063346607","https://openalex.org/W2066010536","https://openalex.org/W2067080332","https://openalex.org/W2069982266","https://openalex.org/W2070531819","https://openalex.org/W2071278402","https://openalex.org/W2080101368","https://openalex.org/W2085266415","https://openalex.org/W2085499593","https://openalex.org/W2087234479","https://openalex.org/W2088281604","https://openalex.org/W2090607082","https://openalex.org/W2092144432","https://openalex.org/W2092595123","https://openalex.org/W2094333855","https://openalex.org/W2108210068","https://openalex.org/W2111478804","https://openalex.org/W2121480111","https://openalex.org/W2153355914","https://openalex.org/W2327883350","https://openalex.org/W3008437073","https://openalex.org/W4205871929"],"related_works":["https://openalex.org/W4236459141","https://openalex.org/W4205304778","https://openalex.org/W2020252434","https://openalex.org/W73248859","https://openalex.org/W2584253892","https://openalex.org/W2350324449","https://openalex.org/W1572705989","https://openalex.org/W119381072","https://openalex.org/W2034033896","https://openalex.org/W2087062149"],"abstract_inverted_index":{"Based":[0],"on":[1,16,154,192,199,205,214,285],"the":[2,17,29,40,51,60,78,81,89,101,119,122,125,129,135,139,142,152,155,159,165,167,172,189,210,232,236,243,266,269,277,292,310,316,319,322],"dynamical":[3,55],"structure":[4,56],"theory":[5,57],"for":[6,20,39,100,217,264],"complex":[7,64],"networks":[8],"recently":[9],"developed":[10,23],"by":[11,24,68,85,128,175,188,197,309],"one":[12,200],"of":[13,62,106,121,141,158,235,254,271,280,291,303,321],"us":[14],"and":[15,26,35,88,112,195,222,268,298,329],"physical-chemical":[18],"models":[19],"gene":[21,306],"regulation,":[22],"Shea":[25],"Ackers":[27],"in":[28,104,124,183,226,295,331],"1980's,":[30],"we":[31,259],"formulate":[32],"a":[33,63,86,98,223,251,289,296],"direct":[34],"concise":[36],"mathematical":[37,245],"framework":[38],"genetic":[41,239,274,325],"switch":[42,275,326],"controlling":[43],"phage":[44,102,123,132,166,194,237,272,323],"lambda":[45,238,273,324],"life":[46],"cycles,":[47],"which":[48],"naturally":[49],"includes":[50],"stochastic":[52,79,162,293],"effect.":[53],"The":[54,73,92,114,131,146,161,229,262,300],"states":[58],"that":[59,247],"dynamics":[61],"network":[65,153],"is":[66,242,276,315],"determined":[67,84],"its":[69],"four":[70],"elementary":[71],"components:":[72],"dissipation":[74,115],"(analogous":[75],"to":[76,118,137,150,169,318],"degradation),":[77],"force,":[80],"driving":[82],"force":[83,148],"potential,":[87],"transverse":[90,147],"force.":[91],"potential":[93,173,286],"may":[94],"be":[95],"interpreted":[96],"as":[97],"landscape":[99,126,174],"development":[103],"terms":[105],"attractive":[107,144],"basins,":[108],"saddle":[109,178,281],"points,":[110],"peaks":[111],"valleys.":[113],"gives":[116,164],"rise":[117],"adaptivity":[120],"defined":[127],"potential:":[130],"always":[133],"has":[134],"tendency":[136],"approach":[138],"bottom":[140],"nearby":[143],"basin.":[145],"tends":[149],"keep":[151],"equal-potential":[156],"contour":[157],"landscape.":[160],"fluctuation":[163],"ability":[168],"search":[170],"around":[171],"passing":[176],"through":[177],"points.":[179],"With":[180],"molecular":[181],"parameters":[182],"our":[184,202],"model":[185],"fixed":[186],"primarily":[187],"experimental":[190,212,256],"data":[191,198],"wild-type":[193],"supplemented":[196],"mutant,":[201],"calculated":[203],"results":[204],"mutants":[206,216],"agree":[207],"quantitatively":[208],"with":[209],"available":[211],"observations":[213],"other":[215],"protein":[218],"number,":[219],"lysogenization":[220],"frequency,":[221],"lysis":[224],"frequency":[225],"lysogen":[227],"culture.":[228],"calculation":[230],"reproduces":[231],"observed":[233],"robustness":[234,320],"switch.":[240],"This":[241],"first":[244],"description":[246],"successfully":[248],"represents":[249],"such":[250],"wide":[252],"variety":[253],"major":[255],"phenomena.":[257],"Specifically,":[258],"find:":[260],"(1)":[261],"explanation":[263],"both":[265],"stability":[267],"efficiency":[270],"exponential":[278],"dependence":[279],"point":[282],"crossing":[283],"rate":[284],"barrier":[287],"height,":[288],"result":[290],"motion":[294],"landscape;":[297],"(2)":[299],"positive":[301],"feedback":[302],"cI":[304],"repressor":[305],"transcription,":[307],"enhanced":[308],"CI":[311],"dimer":[312],"cooperative":[313],"binding,":[314],"key":[317],"against":[327],"mutations":[328],"fluctuations":[330],"kinetic":[332],"parameter":[333],"values.":[334]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2016-06-24T00:00:00"}