{"id":"https://openalex.org/W2165519901","doi":"https://doi.org/10.1142/s0219720003000228","title":"Conservation of Amino Acids into Multiple Alignments Involved in Pairwise Interactions in Three-Dimensional Protein Structures","display_name":"Conservation of Amino Acids into Multiple Alignments Involved in Pairwise Interactions in Three-Dimensional Protein Structures","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W2165519901","doi":"https://doi.org/10.1142/s0219720003000228","mag":"2165519901","pmid":"https://pubmed.ncbi.nlm.nih.gov/15307241"},"language":"en","primary_location":{"id":"doi:10.1142/s0219720003000228","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720003000228","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091502342","display_name":"Mounir Errami","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087293","display_name":"Institut de Biologie et de Chimie des Prot\u00e9ines","ror":"https://ror.org/0019x5d05","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210087293","https://openalex.org/I4210096427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mounir Errami","raw_affiliation_strings":["P\u00f4le Bioinformatique  Lyonnais-Institut de Biologie et Chimie des Prot\u00e9ines,  Laboratoire de Bioinformatique et RMN structurales, 7,  passage du Vercors, 69367 Lyon cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P\u00f4le Bioinformatique  Lyonnais-Institut de Biologie et Chimie des Prot\u00e9ines,  Laboratoire de Bioinformatique et RMN structurales, 7,  passage du Vercors, 69367 Lyon cedex, France","institution_ids":["https://openalex.org/I4210087293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078253318","display_name":"C. Geourjon","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087293","display_name":"Institut de Biologie et de Chimie des Prot\u00e9ines","ror":"https://ror.org/0019x5d05","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210087293","https://openalex.org/I4210096427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Geourjon","raw_affiliation_strings":["P\u00f4le Bioinformatique  Lyonnais-Institut de Biologie et Chimie des Prot\u00e9ines,  Laboratoire de Bioinformatique et RMN structurales, 7,  passage du Vercors, 69367 Lyon cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P\u00f4le Bioinformatique  Lyonnais-Institut de Biologie et Chimie des Prot\u00e9ines,  Laboratoire de Bioinformatique et RMN structurales, 7,  passage du Vercors, 69367 Lyon cedex, France","institution_ids":["https://openalex.org/I4210087293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009109452","display_name":"Gilbert Del\u00e9age","orcid":"https://orcid.org/0000-0003-1939-1614"},"institutions":[{"id":"https://openalex.org/I4210087293","display_name":"Institut de Biologie et de Chimie des Prot\u00e9ines","ror":"https://ror.org/0019x5d05","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210087293","https://openalex.org/I4210096427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gilbert Del\u00e9age","raw_affiliation_strings":["P\u00f4le Bioinformatique  Lyonnais-Institut de Biologie et Chimie des Prot\u00e9ines,  Laboratoire de Bioinformatique et RMN structurales, 7,  passage du Vercors, 69367 Lyon cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P\u00f4le Bioinformatique  Lyonnais-Institut de Biologie et Chimie des Prot\u00e9ines,  Laboratoire de Bioinformatique et RMN structurales, 7,  passage du Vercors, 69367 Lyon cedex, France","institution_ids":["https://openalex.org/I4210087293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087293"],"apc_list":null,"apc_paid":null,"fwci":0.1146,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.49054199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"01","issue":"03","first_page":"505","last_page":"520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9854999780654907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.7471632957458496},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.5762946605682373},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.503602921962738},{"id":"https://openalex.org/keywords/structural-alignment","display_name":"Structural alignment","score":0.4875776171684265},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.458414763212204},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.3807668089866638},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34866899251937866},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3034568130970001},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2608838677406311},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.2344549000263214},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11913222074508667}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.7471632957458496},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5762946605682373},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.503602921962738},{"id":"https://openalex.org/C4668613","wikidata":"https://www.wikidata.org/wiki/Q4116110","display_name":"Structural alignment","level":5,"score":0.4875776171684265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.458414763212204},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.3807668089866638},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34866899251937866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3034568130970001},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2608838677406311},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2344549000263214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11913222074508667}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012492","descriptor_name":"Salts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012492","descriptor_name":"Salts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012492","descriptor_name":"Salts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219720003000228","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219720003000228","pdf_url":null,"source":{"id":"https://openalex.org/S155349577","display_name":"Journal of Bioinformatics and Computational Biology","issn_l":"0219-7200","issn":["0219-7200","1757-6334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioinformatics and Computational Biology","raw_type":"journal-article"},{"id":"pmid:15307241","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15307241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioinformatics and computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.6899999976158142}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1604980477","https://openalex.org/W1972216879","https://openalex.org/W1974719543","https://openalex.org/W1984874903","https://openalex.org/W1985842673","https://openalex.org/W1999181825","https://openalex.org/W2003144438","https://openalex.org/W2008708467","https://openalex.org/W2013988051","https://openalex.org/W2015292449","https://openalex.org/W2025093242","https://openalex.org/W2054403251","https://openalex.org/W2060791849","https://openalex.org/W2077235131","https://openalex.org/W2077558969","https://openalex.org/W2080107562","https://openalex.org/W2087064593","https://openalex.org/W2106882534","https://openalex.org/W2107488352","https://openalex.org/W2108746608","https://openalex.org/W2120877947","https://openalex.org/W2129999032","https://openalex.org/W2130161623","https://openalex.org/W2130479394","https://openalex.org/W2144472358","https://openalex.org/W2147905080","https://openalex.org/W2148311769","https://openalex.org/W2149994005","https://openalex.org/W2158714788","https://openalex.org/W2161991622","https://openalex.org/W2162913079","https://openalex.org/W2163526800","https://openalex.org/W2168095997","https://openalex.org/W4213149192"],"related_works":["https://openalex.org/W2029514038","https://openalex.org/W2088487249","https://openalex.org/W2111937814","https://openalex.org/W2051969447","https://openalex.org/W1985408726","https://openalex.org/W2061567716","https://openalex.org/W2079145549","https://openalex.org/W2129361631","https://openalex.org/W4389053053","https://openalex.org/W2903170547"],"abstract_inverted_index":{"We":[0,26,40],"present":[1],"an":[2,15],"original":[3],"strategy,":[4],"that":[5,42,61],"involves":[6],"a":[7,68],"bioinformatic":[8],"software":[9],"structure,":[10],"in":[11,46],"order":[12],"to":[13],"perform":[14],"exhaustive":[16],"and":[17,34,51],"objective":[18],"statistical":[19],"analysis":[20],"of":[21,24,38,85],"three-dimensional":[22],"structures":[23],"proteins.":[25,39],"establish":[27],"the":[28,62,65,71,74],"relationship":[29],"between":[30],"multiple":[31,69,75,80],"sequences":[32,66],"alignments":[33,81],"various":[35],"structural":[36,86],"features":[37],"show":[41],"amino":[43],"acids":[44],"implied":[45],"disulfide":[47],"bonds,":[48],"salt":[49],"bridges":[50],"hydrophobic":[52],"interactions":[53],"have":[54],"been":[55],"studied.":[56],"Furthermore,":[57],"we":[58],"point":[59],"out":[60],"more":[63,72],"variable":[64],"within":[67],"alignment,":[70],"informative":[73],"alignment.":[76],"The":[77],"results":[78],"support":[79],"usefulness":[82],"for":[83],"predictions":[84],"features.":[87]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}