{"id":"https://openalex.org/W2115847048","doi":"https://doi.org/10.1142/s0219525909002076","title":"MODEL-BASED IDENTIFICATION AND ADAPTIVE CONTROL OF THE CORE MODULE IN A TYPICAL CELL CYCLE PATHWAY VIA NETWORK AND SYSTEM CONTROL THEORIES","display_name":"MODEL-BASED IDENTIFICATION AND ADAPTIVE CONTROL OF THE CORE MODULE IN A TYPICAL CELL CYCLE PATHWAY VIA NETWORK AND SYSTEM CONTROL THEORIES","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W2115847048","doi":"https://doi.org/10.1142/s0219525909002076","mag":"2115847048"},"language":"en","primary_location":{"id":"doi:10.1142/s0219525909002076","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219525909002076","pdf_url":null,"source":{"id":"https://openalex.org/S107361000","display_name":"Advances in Complex Systems","issn_l":"0219-5259","issn":["0219-5259","1793-6802","1793-9615","1793-9623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Complex Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082800002","display_name":"Binhua Tang","orcid":"https://orcid.org/0000-0003-4744-5835"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"BINHUA TANG","raw_affiliation_strings":["Department of Biomedical Engineering, Tongji University, Shanghai, China","Dept. of Biomedical Engineering, Tongji University, Shanghai, China#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering, Tongji University, Shanghai, China#TAB#","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038740241","display_name":"Li He","orcid":"https://orcid.org/0000-0002-8782-7793"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"LI HE","raw_affiliation_strings":["Department of Electronics & Communications, Sun Yat-Sen University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Department of Electronics & Communications, Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089593108","display_name":"Qing Jing","orcid":"https://orcid.org/0000-0001-9834-1214"},"institutions":[{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"QING JING","raw_affiliation_strings":["Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China"],"affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I4210106477","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081095213","display_name":"Bairong Shen","orcid":"https://orcid.org/0000-0003-2899-1531"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"BAIRONG SHEN","raw_affiliation_strings":["Center for Systems Biology, Soochow University, Suzhou, China"],"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082800002"],"corresponding_institution_ids":["https://openalex.org/I116953780"],"apc_list":null,"apc_paid":null,"fwci":0.5392,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.67110038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"01","first_page":"21","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schema","display_name":"Schema (genetic algorithms)","score":0.5300927758216858},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5300799608230591},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5210953950881958},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.4997525215148926},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.33094316720962524},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24358797073364258},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1785392463207245},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.11051732301712036}],"concepts":[{"id":"https://openalex.org/C52146309","wikidata":"https://www.wikidata.org/wiki/Q7431116","display_name":"Schema (genetic algorithms)","level":2,"score":0.5300927758216858},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5300799608230591},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5210953950881958},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.4997525215148926},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.33094316720962524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24358797073364258},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1785392463207245},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.11051732301712036},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1142/s0219525909002076","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219525909002076","pdf_url":null,"source":{"id":"https://openalex.org/S107361000","display_name":"Advances in Complex Systems","issn_l":"0219-5259","issn":["0219-5259","1793-6802","1793-9615","1793-9623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Complex Systems","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:wsi:acsxxx:v:12:y:2009:i:01:n:s0219525909002076","is_oa":false,"landing_page_url":"http://www.worldscientific.com/doi/abs/10.1142/S0219525909002076","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:RePEc:wsi:acsxxx:v:12:y:2009:i:01:p:21-43","is_oa":false,"landing_page_url":"http://www.worldscinet.com/cgi-bin/details.cgi?type=html&id=pii:S0219525909002076","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W130083205","https://openalex.org/W1486453207","https://openalex.org/W1487127700","https://openalex.org/W1548164611","https://openalex.org/W1558736232","https://openalex.org/W1677575702","https://openalex.org/W1684832135","https://openalex.org/W1964942721","https://openalex.org/W1986276439","https://openalex.org/W2002587733","https://openalex.org/W2004008931","https://openalex.org/W2010683612","https://openalex.org/W2015869454","https://openalex.org/W2025962043","https://openalex.org/W2031869443","https://openalex.org/W2048899019","https://openalex.org/W2053858254","https://openalex.org/W2064702160","https://openalex.org/W2065252383","https://openalex.org/W2082227652","https://openalex.org/W2089442061","https://openalex.org/W2102629189","https://openalex.org/W2104812688","https://openalex.org/W2119877295","https://openalex.org/W2124637492","https://openalex.org/W2127712726","https://openalex.org/W2133254839","https://openalex.org/W2133401281","https://openalex.org/W2136431957","https://openalex.org/W2136931666","https://openalex.org/W2142676005","https://openalex.org/W2144702196","https://openalex.org/W2145394518","https://openalex.org/W2145412406","https://openalex.org/W2150750144","https://openalex.org/W2152875808","https://openalex.org/W2153624566","https://openalex.org/W2171416668","https://openalex.org/W2319412992","https://openalex.org/W4248816015","https://openalex.org/W4298997816"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2487162673","https://openalex.org/W2942366970","https://openalex.org/W2793211469","https://openalex.org/W2949152769","https://openalex.org/W4372354731","https://openalex.org/W2562400057","https://openalex.org/W1692008701","https://openalex.org/W2597588799","https://openalex.org/W4360593462"],"abstract_inverted_index":{"The":[0,35,67],"loss":[1],"of":[2,18,37,47,57,61,90,96,125,132,149],"cell":[3,28],"cycle":[4,29],"control":[5,49,83,116,137,153],"is":[6],"often":[7],"associated":[8],"with":[9],"cancers":[10],"and":[11,45,81,93,104,129,162,170,186],"other":[12],"different":[13],"diseases.":[14],"With":[15],"the":[16,21,27,38,55,58,88,94,106,123,130,136,141,178],"accumulation":[17],"omics":[19],"data,":[20],"network":[22,44,80],"for":[23,63,99,111],"molecule":[24],"interactions":[25],"in":[26,41,72,155,167,182],"process":[30],"will":[31],"become":[32],"much":[33],"clearer.":[34],"identification":[36],"crucial":[39],"modules":[40,77,128],"a":[42,147],"giant":[43],"investigation":[46],"inherent":[48,142],"relations":[50],"are":[51,174],"very":[52],"important":[53],"to":[54],"understanding":[56],"molecular":[59],"mechanisms":[60],"diseases":[62],"new":[64],"drug":[65],"design.":[66],"paper":[68],"proposes":[69],"novel":[70],"techniques":[71],"analyzing":[73],"such":[74],"core":[75,101,127],"regulatory":[76,114,143],"based":[78],"on":[79],"system":[82],"theories.":[84],"We":[85],"initially":[86],"define":[87],"degree":[89],"participation":[91],"(DOP)":[92],"rate":[95],"activity":[97],"(ROA)":[98],"indentifying":[100],"module":[102],"components,":[103,120],"then":[105],"diverse":[107],"contribution":[108],"elasticity":[109],"functions":[110],"quantifying":[112],"pairwise":[113],"or":[115],"activities":[117],"between":[118],"those":[119,181],"thus":[121],"facilitating":[122],"decomposition":[124],"expanded":[126],"formation":[131],"feedback":[133],"loops":[134],"within":[135,177],"schema.":[138],"Motivated":[139],"by":[140],"mechanisms,":[144],"we":[145],"expound":[146],"kind":[148],"multiphase":[150],"nonlinear":[151],"adaptive":[152],"algorithm":[154],"repelling":[156],"abnormal":[157],"genetic":[158],"mutations,":[159],"which":[160],"directly":[161],"indirectly":[163],"impact":[164],"cancer":[165],"development":[166],"biological":[168],"cells":[169],"organs.":[171],"Experimental":[172],"predictions":[173],"also":[175],"elucidated":[176],"work,":[179],"helping":[180],"vivo":[183],"design,":[184],"verification":[185],"performance":[187],"evaluation.":[188]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}