{"id":"https://openalex.org/W2005263851","doi":"https://doi.org/10.1142/s0219525905000427","title":"NEUTRAL NETWORKS OF INTERACTING RNA SECONDARY STRUCTURES","display_name":"NEUTRAL NETWORKS OF INTERACTING RNA SECONDARY STRUCTURES","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2005263851","doi":"https://doi.org/10.1142/s0219525905000427","mag":"2005263851"},"language":"en","primary_location":{"id":"doi:10.1142/s0219525905000427","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219525905000427","pdf_url":null,"source":{"id":"https://openalex.org/S107361000","display_name":"Advances in Complex Systems","issn_l":"0219-5259","issn":["0219-5259","1793-6802","1793-9615","1793-9623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Complex Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ul.qucosa.de/id/qucosa%3A31863","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085139761","display_name":"Camille Stephan\u2010Otto Attolini","orcid":"https://orcid.org/0000-0001-8045-320X"},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"CAMILLE STEPHAN-OTTO ATTOLINI","raw_affiliation_strings":["Institut f\u00fcr Theoretische Chemie, Universit\u00e4t Wien, W\u00e4hringerstra\u00dfe 17, A-1090 Wien, Austria"],"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Theoretische Chemie, Universit\u00e4t Wien, W\u00e4hringerstra\u00dfe 17, A-1090 Wien, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016104736","display_name":"Peter F. Stadler","orcid":"https://orcid.org/0000-0002-5016-5191"},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["AT","DE","US"],"is_corresponding":false,"raw_author_name":"PETER F. STADLER","raw_affiliation_strings":["Institut f\u00fcr Theoretische Chemie, Universit\u00e4t Wien, W\u00e4hringerstra\u00dfe 17, A-1090 Wien, Austria","Lehrstuhl f\u00fcr Bioinformatik, Institut f\u00fcr Informatik, Universit\u00e4t Leipzig, Kreuzstra\u00dfe 7a, D-04103 Leipzig, Germany","The Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe NM 87501, USA"],"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Theoretische Chemie, Universit\u00e4t Wien, W\u00e4hringerstra\u00dfe 17, A-1090 Wien, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Lehrstuhl f\u00fcr Bioinformatik, Institut f\u00fcr Informatik, Universit\u00e4t Leipzig, Kreuzstra\u00dfe 7a, D-04103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"The Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe NM 87501, USA","institution_ids":["https://openalex.org/I1308548392"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085139761"],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":null,"apc_paid":null,"fwci":0.2532,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.54911612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"08","issue":"02n03","first_page":"275","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.8007440567016602},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5982482433319092},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.55040442943573},{"id":"https://openalex.org/keywords/base-pair","display_name":"Base pair","score":0.5367879271507263},{"id":"https://openalex.org/keywords/nucleic-acid-structure","display_name":"Nucleic acid structure","score":0.44310712814331055},{"id":"https://openalex.org/keywords/nucleic-acid-secondary-structure","display_name":"Nucleic acid secondary structure","score":0.4347992241382599},{"id":"https://openalex.org/keywords/base","display_name":"Base (topology)","score":0.4113020598888397},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39087745547294617},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3850354552268982},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3529356122016907},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32451820373535156},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.21549147367477417},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20419016480445862},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1639641523361206},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10916063189506531}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.8007440567016602},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5982482433319092},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.55040442943573},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.5367879271507263},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.44310712814331055},{"id":"https://openalex.org/C85468374","wikidata":"https://www.wikidata.org/wiki/Q6589957","display_name":"Nucleic acid secondary structure","level":4,"score":0.4347992241382599},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.4113020598888397},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39087745547294617},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3850354552268982},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3529356122016907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32451820373535156},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.21549147367477417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20419016480445862},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1639641523361206},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10916063189506531},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1142/s0219525905000427","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219525905000427","pdf_url":null,"source":{"id":"https://openalex.org/S107361000","display_name":"Advances in Complex Systems","issn_l":"0219-5259","issn":["0219-5259","1793-6802","1793-9615","1793-9623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Complex Systems","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.188.6886","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.188.6886","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://lips.informatik.uni-leipzig.de/files/Attolini2005NeutralNetworksofInteractingRNASecondaryStructures.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.84.4036","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.84.4036","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bioinf.uni-leipzig.de/~camille/cofstats.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:wsi:acsxxx:v:08:y:2005:i:02:p:275-283","is_oa":false,"landing_page_url":"http://www.worldscinet.com/cgi-bin/details.cgi?type=html&id=pii:S0219525905000427","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:RePEc:wsi:acsxxx:v:08:y:2005:i:02n03:n:s0219525905000427","is_oa":false,"landing_page_url":"http://www.worldscientific.com/doi/abs/10.1142/S0219525905000427","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:lips.informatik.uni-leipzig.de:1610","is_oa":false,"landing_page_url":"http://lips.informatik.uni-leipzig.de/?q=node/1610","pdf_url":null,"source":{"id":"https://openalex.org/S4377196964","display_name":"Publikation Server (Leipzig University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I926574661","host_organization_name":"Leipzig University","host_organization_lineage":["https://openalex.org/I926574661"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adv. Complex Syst, 8: 275-284 (2005)","raw_type":""},{"id":"pmh:oai:qucosa:de:qucosa:31863","is_oa":true,"landing_page_url":"https://ul.qucosa.de/id/qucosa%3A31863","pdf_url":null,"source":{"id":"https://openalex.org/S4377196312","display_name":"Qucosa (Saxon State and University Library Dresden)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I3132420320","host_organization_name":"SLUB Dresden","host_organization_lineage":["https://openalex.org/I3132420320"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:Text"}],"best_oa_location":{"id":"pmh:oai:qucosa:de:qucosa:31863","is_oa":true,"landing_page_url":"https://ul.qucosa.de/id/qucosa%3A31863","pdf_url":null,"source":{"id":"https://openalex.org/S4377196312","display_name":"Qucosa (Saxon State and University Library Dresden)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I3132420320","host_organization_name":"SLUB Dresden","host_organization_lineage":["https://openalex.org/I3132420320"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.6499999761581421}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320301","display_name":"European Science Foundation","ror":"https://ror.org/04esata81"},{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1543796220","https://openalex.org/W1551334274","https://openalex.org/W1552834166","https://openalex.org/W1569069879","https://openalex.org/W1970957621","https://openalex.org/W1971013467","https://openalex.org/W1971399377","https://openalex.org/W1977940795","https://openalex.org/W2000026592","https://openalex.org/W2022916085","https://openalex.org/W2045391589","https://openalex.org/W2046585679","https://openalex.org/W2052214482","https://openalex.org/W2076963640","https://openalex.org/W2089339672","https://openalex.org/W2093108225","https://openalex.org/W2094253263","https://openalex.org/W2103250001","https://openalex.org/W2114389487","https://openalex.org/W2321457778","https://openalex.org/W3012079654","https://openalex.org/W3124837637","https://openalex.org/W4255996317"],"related_works":["https://openalex.org/W4386361828","https://openalex.org/W576226539","https://openalex.org/W2808896479","https://openalex.org/W2133070749","https://openalex.org/W1978187259","https://openalex.org/W2061103938","https://openalex.org/W2889983362","https://openalex.org/W2136556521","https://openalex.org/W2982356100","https://openalex.org/W2029624882"],"abstract_inverted_index":{"RNA":[0,44,113],"molecules":[1],"interact":[2],"by":[3],"forming":[4],"inter-molecular":[5],"base":[6,13],"pairs":[7,14],"that":[8,48,63,97],"compete":[9],"with":[10,33,39,87,110,122],"the":[11,21,31,37,50,81,84,103],"intra-molecular":[12],"of":[15,23,52,83,105],"their":[16,128],"secondary":[17],"structures.":[18],"We":[19,46],"investigate":[20],"patterns":[22],"neutral":[24],"mutations":[25],"in":[26,57],"RNAs":[27,59,62,98,121],"whose":[28,99],"function":[29,100,124],"is":[30,54],"interaction":[32,108],"other":[34,43],"RNAs,":[35],"i.e.":[36],"co-folding":[38],"one":[40],"or":[41,89],"more":[42,90,118],"molecules.":[45],"find":[47],"(i)":[49],"degree":[51],"neutrality":[53],"much":[55,117],"smaller":[56],"interacting":[58],"compared":[60],"to":[61,66,68,80],"just":[64],"have":[65],"coform":[67],"a":[69,106,111,123],"single":[70],"externally":[71],"prescribed":[72],"target":[73,112],"structure,":[74],"and":[75],"(ii)":[76],"strengthening":[77],"this":[78],"contraint":[79],"conservation":[82],"co-folded":[85],"structure":[86],"two":[88],"partners":[91],"essentially":[92],"eliminates":[93],"neutrality.":[94],"It":[95],"follows":[96],"depends":[101],"on":[102,127],"formation":[104],"specific":[107],"complex":[109],"molecule":[114],"will":[115],"evolve":[116],"slowly":[119],"than":[120],"depending":[125],"only":[126],"own":[129],"structure.":[130]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}