{"id":"https://openalex.org/W2790582919","doi":"https://doi.org/10.1142/s0219467818500018","title":"Automatic Quantification of Endothelial Nitric Oxide Levels in a Microvessel with and without Tumor Cell Adhesion","display_name":"Automatic Quantification of Endothelial Nitric Oxide Levels in a Microvessel with and without Tumor Cell Adhesion","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2790582919","doi":"https://doi.org/10.1142/s0219467818500018","mag":"2790582919"},"language":"en","primary_location":{"id":"doi:10.1142/s0219467818500018","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219467818500018","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219467818500018","source":{"id":"https://openalex.org/S60080701","display_name":"International Journal of Image and Graphics","issn_l":"0219-4678","issn":["0219-4678","1793-6756"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Image and Graphics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219467818500018","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101428622","display_name":"Jie Wei","orcid":"https://orcid.org/0000-0003-1781-6412"},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Wei","raw_affiliation_strings":["Department of Computer Science, City College of New York, New York 10031, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, City College of New York, New York 10031, USA","institution_ids":["https://openalex.org/I125687163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351849","display_name":"Lin Zhang","orcid":"https://orcid.org/0000-0002-4360-5523"},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Department of Biomedical Engineering, City College of New York, New York 10031, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, City College of New York, New York 10031, USA","institution_ids":["https://openalex.org/I125687163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000680941","display_name":"Bingmei M. Fu","orcid":"https://orcid.org/0000-0001-9343-5895"},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bingmei M. Fu","raw_affiliation_strings":["Department of Biomedical Engineering, City College of New York, New York 10031, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, City College of New York, New York 10031, USA","institution_ids":["https://openalex.org/I125687163"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101428622"],"corresponding_institution_ids":["https://openalex.org/I125687163"],"apc_list":null,"apc_paid":null,"fwci":0.1045,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.40820762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"01","first_page":"1850001","last_page":"1850001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9817000031471252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9298999905586243,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microvessel","display_name":"Microvessel","score":0.9049228429794312},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"Nitric oxide","score":0.5977030396461487},{"id":"https://openalex.org/keywords/enos","display_name":"Enos","score":0.5954785346984863},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4022577404975891},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3387554883956909},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3346000909805298},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"Nitric oxide synthase","score":0.31077873706817627},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.278914213180542},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.1988126039505005},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13827598094940186}],"concepts":[{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.9049228429794312},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5977030396461487},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.5954785346984863},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4022577404975891},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3387554883956909},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3346000909805298},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.31077873706817627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.278914213180542},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1988126039505005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13827598094940186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0219467818500018","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219467818500018","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219467818500018","source":{"id":"https://openalex.org/S60080701","display_name":"International Journal of Image and Graphics","issn_l":"0219-4678","issn":["0219-4678","1793-6756"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Image and Graphics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1142/s0219467818500018","is_oa":true,"landing_page_url":"https://doi.org/10.1142/s0219467818500018","pdf_url":"https://www.worldscientific.com/doi/pdf/10.1142/S0219467818500018","source":{"id":"https://openalex.org/S60080701","display_name":"International Journal of Image and Graphics","issn_l":"0219-4678","issn":["0219-4678","1793-6756"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Image and Graphics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2790582919.pdf","grobid_xml":"https://content.openalex.org/works/W2790582919.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1503398984","https://openalex.org/W1511986666","https://openalex.org/W1533162639","https://openalex.org/W1604034532","https://openalex.org/W1972673189","https://openalex.org/W1983989471","https://openalex.org/W1989091929","https://openalex.org/W1991113069","https://openalex.org/W2003692806","https://openalex.org/W2021014729","https://openalex.org/W2032476576","https://openalex.org/W2063533773","https://openalex.org/W2104095591","https://openalex.org/W2162955172","https://openalex.org/W2286471756","https://openalex.org/W2951920181","https://openalex.org/W3137241515","https://openalex.org/W3200493159","https://openalex.org/W3211330693","https://openalex.org/W4205806204","https://openalex.org/W4242134579","https://openalex.org/W4246219036","https://openalex.org/W4250589301","https://openalex.org/W4251147723","https://openalex.org/W4292963524","https://openalex.org/W4300235817"],"related_works":["https://openalex.org/W2002027447","https://openalex.org/W247954563","https://openalex.org/W3029155473","https://openalex.org/W2392311598","https://openalex.org/W2369406526","https://openalex.org/W2098776639","https://openalex.org/W1998792901","https://openalex.org/W1973054716","https://openalex.org/W2028156322","https://openalex.org/W2050559178"],"abstract_inverted_index":{"Elevated":[0],"nitric":[1,6],"oxide":[2,7],"(NO)":[3],"and":[4,39,81,86,110,143,149,174,183],"endothelial":[5,50],"synthase":[8],"(eNOS)":[9],"have":[10],"been":[11],"observed":[12],"in":[13,16,26,115,179],"cancer":[14],"patients":[15,31],"malignancy":[17],"state.":[18],"We":[19],"hypothesize":[20],"that":[21],"the":[22,27,55,102,107,116,118,132,135,152,156,168,172,176,180],"higher":[23],"NO":[24,66,96,177,199],"production":[25],"microvessels":[28,114],"of":[29,49,76,106,113],"these":[30],"attracts":[32],"more":[33],"tumor":[34],"cells":[35,51],"(TCs)":[36],"to":[37,47,61,94,129,146,166,171,194,203],"adhere":[38],"accomplish":[40],"their":[41],"metastases.":[42],"Since":[43],"there":[44],"are":[45],"tens":[46],"hundreds":[48],"(ECs)":[52],"forming":[53],"on":[54,151],"microvessel":[56,133,153,173],"walls,":[57],"it":[58],"is":[59,164],"unsustainable":[60],"let":[62],"human":[63,206],"operators":[64],"measure":[65],"intensity":[67,97],"levels":[68],"by":[69,205],"correlating":[70],"TC":[71,169,185],"maps":[72],"with":[73,182],"a":[74,122,160,188],"multitude":[75],"microphotographs":[77,99],"via":[78],"manual":[79],"labor":[80],"eyeballing.":[82],"To":[83],"achieve":[84],"effective":[85],"scalable":[87],"quantifications,":[88],"we":[89],"developed":[90],"an":[91],"automatic":[92],"algorithm":[93,197],"quantify":[95],"for":[98],"taken":[100],"from":[101,134,155,192],"experiments.":[103],"Taking":[104],"account":[105],"special":[108],"visual":[109],"geometric":[111],"properties":[112],"study,":[117],"first":[119],"step":[120,139],"performs":[121],"novel":[123],"Markov":[124],"integrated":[125],"dynamic":[126],"programming":[127],"procedure":[128,163],"single":[130],"out":[131],"microphotograph.":[136],"The":[137],"next":[138],"applies":[140],"image":[141],"processing":[142,189],"morphological":[144],"operations":[145],"identify":[147],"ECs":[148,181],"TCs":[150],"detected":[154],"prior":[157],"step.":[158],"Finally,":[159],"normalized":[161],"cross-correlation":[162],"applied":[165],"register":[167],"map":[170],"evaluate":[175],"ratios":[178,200],"without":[184],"adhesions.":[186],"With":[187],"time":[190],"reduced":[191],"hours":[193],"seconds,":[195],"this":[196],"evaluates":[198],"exceedingly":[201],"similar":[202],"those":[204],"operators.":[207]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}