{"id":"https://openalex.org/W2062340020","doi":"https://doi.org/10.1142/s0219265911002964","title":"METABOLIC NETWORKS ROBUSTNESS: THEORY, SIMULATIONS AND RESULTS","display_name":"METABOLIC NETWORKS ROBUSTNESS: THEORY, SIMULATIONS AND RESULTS","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2062340020","doi":"https://doi.org/10.1142/s0219265911002964","mag":"2062340020"},"language":"en","primary_location":{"id":"doi:10.1142/s0219265911002964","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219265911002964","pdf_url":null,"source":{"id":"https://openalex.org/S63112013","display_name":"Journal of Interconnection Networks","issn_l":"0219-2659","issn":["0219-2659","1793-6713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interconnection Networks","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016477001","display_name":"Salvatore Vitabile","orcid":"https://orcid.org/0000-0002-2673-8551"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SALVATORE VITABILE","raw_affiliation_strings":["Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, via del Vespro, Palermo, 90127, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, via del Vespro, Palermo, 90127, Italia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057228633","display_name":"Vincenzo Conti","orcid":"https://orcid.org/0000-0002-8718-111X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VINCENZO CONTI","raw_affiliation_strings":["Facolt\u00e0 di Ingegneria e Architettura e delle Scienze Motorie, Cittadella Universitaria, Enna, 94100, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facolt\u00e0 di Ingegneria e Architettura e delle Scienze Motorie, Cittadella Universitaria, Enna, 94100, Italia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059445778","display_name":"Barbara Lanza","orcid":"https://orcid.org/0000-0002-9588-793X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BARBARA LANZA","raw_affiliation_strings":["Dipartimento di Ingegneria Chimica, Gestionale, Informatica, Meccanica, viale delle Scienze Palermo, 90128, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Ingegneria Chimica, Gestionale, Informatica, Meccanica, viale delle Scienze Palermo, 90128, Italia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017161550","display_name":"Domenico Cusumano","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DOMENICO CUSUMANO","raw_affiliation_strings":["Dipartimento di Ingegneria Chimica, Gestionale, Informatica, Meccanica, viale delle Scienze Palermo, 90128, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Ingegneria Chimica, Gestionale, Informatica, Meccanica, viale delle Scienze Palermo, 90128, Italia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113621241","display_name":"FLIPPO SORBELLO","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FLIPPO SORBELLO","raw_affiliation_strings":["Dipartimento di Ingegneria Chimica, Gestionale, Informatica, Meccanica, viale delle Scienze Palermo, 90128, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Ingegneria Chimica, Gestionale, Informatica, Meccanica, viale delle Scienze Palermo, 90128, Italia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1311,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.52609055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"03","first_page":"221","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.868557870388031},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.7755026817321777},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7144418954849243},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.4942770004272461},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"Cellular metabolism","score":0.48444464802742004},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.47076061367988586},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.4616561830043793},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.458133727312088},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.3722667098045349},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.2722238302230835},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22305065393447876},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.16478708386421204},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08881458640098572},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07568410038948059}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.868557870388031},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.7755026817321777},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7144418954849243},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.4942770004272461},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.48444464802742004},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.47076061367988586},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4616561830043793},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.458133727312088},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.3722667098045349},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2722238302230835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22305065393447876},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.16478708386421204},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08881458640098572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07568410038948059},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1142/s0219265911002964","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0219265911002964","pdf_url":null,"source":{"id":"https://openalex.org/S63112013","display_name":"Journal of Interconnection Networks","issn_l":"0219-2659","issn":["0219-2659","1793-6713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interconnection Networks","raw_type":"journal-article"},{"id":"pmh:oai:iris.unipa.it:10447/74079","is_oa":false,"landing_page_url":"http://hdl.handle.net/10447/74079","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W7653879","https://openalex.org/W1654393620","https://openalex.org/W1947595544","https://openalex.org/W1965518203","https://openalex.org/W1978486653","https://openalex.org/W1980911621","https://openalex.org/W1983202741","https://openalex.org/W2011401040","https://openalex.org/W2017987256","https://openalex.org/W2018045523","https://openalex.org/W2024665458","https://openalex.org/W2026089579","https://openalex.org/W2032074709","https://openalex.org/W2037614307","https://openalex.org/W2038195874","https://openalex.org/W2065769502","https://openalex.org/W2103170157","https://openalex.org/W2112090702","https://openalex.org/W2117364474","https://openalex.org/W2124637492","https://openalex.org/W2136489450","https://openalex.org/W2142522788","https://openalex.org/W2144885342","https://openalex.org/W2146685645","https://openalex.org/W2153020710","https://openalex.org/W2163480486","https://openalex.org/W2401635999","https://openalex.org/W3103071483","https://openalex.org/W3103786587","https://openalex.org/W3146956997","https://openalex.org/W4291733759","https://openalex.org/W4312512934"],"related_works":["https://openalex.org/W2029483977","https://openalex.org/W2063475537","https://openalex.org/W2341681417","https://openalex.org/W1961707331","https://openalex.org/W2012938657","https://openalex.org/W1578136679","https://openalex.org/W2950614386","https://openalex.org/W2096004952","https://openalex.org/W2093241068","https://openalex.org/W2037614307"],"abstract_inverted_index":{"Metabolic":[0],"networks":[1,49,69,123,158],"are":[2,50,136],"composed":[3],"of":[4,17,32,166],"several":[5],"functional":[6,113,134],"modules,":[7],"reproducing":[8],"metabolic":[9,39,48,68,89,122,141,157],"pathways":[10],"and":[11,36,78,133,148],"describing":[12],"the":[13,21,30,72,95,105,108,164,167],"entire":[14],"cellular":[15],"metabolism":[16],"an":[18,24,118],"organism.":[19],"In":[20,115],"last":[22],"decade,":[23],"enormous":[25],"interest":[26],"has":[27],"grown":[28],"for":[29,121],"study":[31],"tolerance":[33],"to":[34,52,57,139,162],"errors":[35],"attacks":[37,59,83,99],"in":[38],"networks.":[40],"Studies":[41],"on":[42,67],"their":[43],"robustness":[44,124],"have":[45,159],"suggested":[46],"that":[47,71],"tolerant":[51],"errors,":[53],"but":[54],"very":[55],"vulnerable":[56],"targeted":[58,152],"against":[60],"highly":[61],"connected":[62],"nodes.":[63],"However,":[64],"many":[65],"findings":[66],"suggest":[70],"above":[73],"classification":[74],"is":[75,107,126],"too":[76],"simple":[77],"imprecise,":[79],"since":[80],"hub":[81],"node":[82,106],"can":[84,91,100],"be":[85,92],"by-passed":[86],"if":[87],"alternative":[88],"paths":[90],"exploited.":[93],"On":[94],"contrary,":[96],"non-hub":[97],"nodes":[98],"affect":[101],"cell":[102],"survival":[103],"when":[104],"only":[109],"path":[110],"within":[111],"a":[112],"module.":[114],"this":[116],"paper":[117],"integrated":[119],"approach":[120],"analysis":[125,135],"presented.":[127],"With":[128],"more":[129],"details,":[130],"statistical,":[131],"topological,":[132],"used":[137,161],"together":[138],"evaluate":[140],"network":[142],"behavior":[143],"under":[144,149],"normal":[145],"operation":[146],"conditions":[147],"random":[150],"or":[151],"attacks.":[153],"Two":[154],"real":[155],"biological":[156],"been":[160],"test":[163],"effectiveness":[165],"proposed":[168],"approach.":[169]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
