{"id":"https://openalex.org/W4400837379","doi":"https://doi.org/10.1142/s0218213024500039","title":"A Systematic Review on Drug-to-Drug Interaction Prediction and Cryptographic Mechanism for Secure Drug Discovery Using AI Techniques","display_name":"A Systematic Review on Drug-to-Drug Interaction Prediction and Cryptographic Mechanism for Secure Drug Discovery Using AI Techniques","publication_year":2024,"publication_date":"2024-07-19","ids":{"openalex":"https://openalex.org/W4400837379","doi":"https://doi.org/10.1142/s0218213024500039"},"language":"en","primary_location":{"id":"doi:10.1142/s0218213024500039","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218213024500039","pdf_url":null,"source":{"id":"https://openalex.org/S178780388","display_name":"International Journal of Artificial Intelligence Tools","issn_l":"0218-2130","issn":["0218-2130","1793-6349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal on Artificial Intelligence Tools","raw_type":"journal-article"},"type":"review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040129803","display_name":"K. Soni Sharmila","orcid":"https://orcid.org/0000-0002-7386-0963"},"institutions":[{"id":"https://openalex.org/I145286018","display_name":"SRM Institute of Science and Technology","ror":"https://ror.org/050113w36","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. Soni Sharmila","raw_affiliation_strings":["School of Computing, SRM Institute of Science and Technology, Kattankulathur 603203, India"],"raw_orcid":"https://orcid.org/0000-0002-7386-0963","affiliations":[{"raw_affiliation_string":"School of Computing, SRM Institute of Science and Technology, Kattankulathur 603203, India","institution_ids":["https://openalex.org/I145286018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101851024","display_name":"S. Thanga Revathi","orcid":null},"institutions":[{"id":"https://openalex.org/I145286018","display_name":"SRM Institute of Science and Technology","ror":"https://ror.org/050113w36","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. Thanga Revathi","raw_affiliation_strings":["School of Computing, SRM Institute of Science and Technology, Kattankulathur 603203, India"],"raw_orcid":"https://orcid.org/0000-0003-1518-006X","affiliations":[{"raw_affiliation_string":"School of Computing, SRM Institute of Science and Technology, Kattankulathur 603203, India","institution_ids":["https://openalex.org/I145286018"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036404059","display_name":"Kiran Sree Pokkuluri","orcid":"https://orcid.org/0000-0001-8601-4304"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pokkuluri Kiran Sree","raw_affiliation_strings":["Department of Computer Science & Engineering, Shri Vishnu Engineering College for Women, Bhimavaram, Andhra Pradesh 534202, India"],"raw_orcid":"https://orcid.org/0000-0001-8601-4304","affiliations":[{"raw_affiliation_string":"Department of Computer Science & Engineering, Shri Vishnu Engineering College for Women, Bhimavaram, Andhra Pradesh 534202, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9432,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.77382664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"33","issue":"08","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9420999884605408,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9420999884605408,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.8554636240005493},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5654871463775635},{"id":"https://openalex.org/keywords/cryptography","display_name":"Cryptography","score":0.5563743710517883},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5465667843818665},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5026609897613525},{"id":"https://openalex.org/keywords/drug-drug-interaction","display_name":"Drug-drug interaction","score":0.41286394000053406},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.3367313742637634},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.23385873436927795},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1295352578163147},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.10975968837738037}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8554636240005493},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5654871463775635},{"id":"https://openalex.org/C178489894","wikidata":"https://www.wikidata.org/wiki/Q8789","display_name":"Cryptography","level":2,"score":0.5563743710517883},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5465667843818665},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5026609897613525},{"id":"https://openalex.org/C2910466267","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug-drug interaction","level":3,"score":0.41286394000053406},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.3367313742637634},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23385873436927795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1295352578163147},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10975968837738037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0218213024500039","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218213024500039","pdf_url":null,"source":{"id":"https://openalex.org/S178780388","display_name":"International Journal of Artificial Intelligence Tools","issn_l":"0218-2130","issn":["0218-2130","1793-6349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal on Artificial Intelligence Tools","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1873975405","https://openalex.org/W1916407220","https://openalex.org/W1991833417","https://openalex.org/W2170786724","https://openalex.org/W2284826680","https://openalex.org/W2397757171","https://openalex.org/W2485374661","https://openalex.org/W2497965792","https://openalex.org/W2528213836","https://openalex.org/W2565076951","https://openalex.org/W2753588101","https://openalex.org/W2767891136","https://openalex.org/W2775773698","https://openalex.org/W2786016794","https://openalex.org/W2792587241","https://openalex.org/W2807280045","https://openalex.org/W2826750344","https://openalex.org/W2835216631","https://openalex.org/W2888696412","https://openalex.org/W2898784679","https://openalex.org/W2904228646","https://openalex.org/W2904451610","https://openalex.org/W2910406387","https://openalex.org/W2911593829","https://openalex.org/W2912247484","https://openalex.org/W2922229918","https://openalex.org/W2947182475","https://openalex.org/W2965042294","https://openalex.org/W2974658886","https://openalex.org/W2975881542","https://openalex.org/W2979781394","https://openalex.org/W2995738274","https://openalex.org/W3014023159","https://openalex.org/W3014482292","https://openalex.org/W3019826089","https://openalex.org/W3024894285","https://openalex.org/W3025257690","https://openalex.org/W3081201079","https://openalex.org/W3095775920","https://openalex.org/W3110140615","https://openalex.org/W3110933132","https://openalex.org/W3126807607","https://openalex.org/W3127950502","https://openalex.org/W3129168016","https://openalex.org/W3136021864","https://openalex.org/W3153939186","https://openalex.org/W3160208619","https://openalex.org/W3164864805","https://openalex.org/W3172835972","https://openalex.org/W3175801695","https://openalex.org/W3193719766","https://openalex.org/W3195617298","https://openalex.org/W3208102118","https://openalex.org/W3213871890","https://openalex.org/W3214855587","https://openalex.org/W4200565005","https://openalex.org/W4206247747","https://openalex.org/W4233069070","https://openalex.org/W4281850946","https://openalex.org/W4285008608","https://openalex.org/W4291465187","https://openalex.org/W4295969306","https://openalex.org/W4296044817","https://openalex.org/W4309928706","https://openalex.org/W4310014465","https://openalex.org/W4312210475","https://openalex.org/W4313395417","https://openalex.org/W4313558164","https://openalex.org/W4317608999"],"related_works":["https://openalex.org/W3082755771","https://openalex.org/W2395332729","https://openalex.org/W2407625558","https://openalex.org/W2485789143","https://openalex.org/W2415873281","https://openalex.org/W2040338448","https://openalex.org/W2463344692","https://openalex.org/W4248267070","https://openalex.org/W2341529717","https://openalex.org/W4251539487"],"abstract_inverted_index":{"Recently,":[0],"poly-pharmacy":[1],"persistence":[2],"has":[3,61],"greatly":[4],"improved":[5],"in":[6,47,89,167,180,208,226,233,251,263],"treating":[7],"multiple":[8],"diseases":[9],"effectively.":[10,211],"However,":[11],"determining":[12],"potential":[13],"drug\u2013drug":[14],"interaction":[15],"(DDIs)":[16],"during":[17,29],"the":[18,25,33,49,73,134,146,152,183,187,195,204,217,227,243,247,252,264],"drug":[19,28,55],"design":[20],"is":[21,159,230],"critical":[22,153],"for":[23,39,53,148,186,194,206],"controlling":[24],"target":[26],"clinical":[27],"secure":[30],"testing.":[31],"In":[32],"medical":[34,228],"field,":[35],"DDIs":[36,67],"are":[37,137,177,198,220],"significant":[38],"disease":[40],"diagnosis":[41],"and":[42,97,116,124,133,161,174,201,223],"treatment,":[43],"mainly":[44],"aiding":[45,80],"researchers":[46,64,244],"predicting":[48],"link":[50],"between":[51],"biomolecules":[52],"efficient":[54],"discovery":[56],"(DD).":[57],"Artificial":[58],"intelligence":[59],"(AI)":[60],"recently":[62],"witnessed":[63],"accurately":[65],"predict":[66],"at":[68],"minimum":[69],"time":[70],"consumption.":[71],"Although":[72],"AI":[74,108],"models":[75],"show":[76],"accurate":[77],"results":[78],"by":[79,216],"physicians":[81],"to":[82,93,102,120,156,163,182,245],"determine":[83],"poly-pharmacy,":[84],"several":[85],"unresolvable":[86],"issues":[87,165,249],"remain":[88],"promoting":[90],"reliability":[91],"due":[92],"high":[94],"error,":[95],"complexity":[96],"cost-effectiveness.":[98],"This":[99],"paper":[100],"aims":[101],"provide":[103],"a":[104,142,257],"comprehensive":[105],"review":[106,235,238],"using":[107],"techniques":[109,119,197,210],"(machine":[110],"learning":[111,113],"(ML)\u2013deep":[112],"(DL)":[114],"models)":[115],"security":[117,135,184],"enhancement":[118],"improve":[121],"DDI":[122,131],"prediction":[123,132],"DD,":[125],"respectively.":[126],"The":[127,212,237],"recent":[128],"state":[129],"of":[130,239],"concerns":[136],"presented":[138],"initially,":[139],"along":[140],"with":[141],"short":[143],"discussion":[144],"about":[145],"need":[147,205],"effective":[149],"techniques.":[150],"Then,":[151],"evaluation":[154],"related":[155],"existing":[157,169,218],"studies":[158,219],"analyzed":[160],"compared":[162],"current":[164],"faced":[166,250],"those":[168],"studies.":[170,266],"Various":[171],"pharmaceutical":[172,253],"drugs":[173],"their":[175,224],"pros":[176],"also":[178,199,221,231],"surveyed":[179,196],"addition":[181],"analysis":[185],"newly":[188],"invented":[189],"drugs.":[190],"Several":[191],"assessment":[192],"measures":[193],"conquered":[200],"put":[202],"forth":[203],"advancements":[207],"future":[209],"performance":[213],"variations":[214],"produced":[215],"surveyed,":[222],"use":[225],"industry":[229,254],"provided":[232],"this":[234,240],"study.":[236],"research":[241],"encourages":[242],"analyze":[246],"various":[248],"so":[255],"that":[256],"novel":[258],"technique":[259],"can":[260],"be":[261],"introduced":[262],"upcoming":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-23T13:55:30.953635","created_date":"2025-10-10T00:00:00"}