{"id":"https://openalex.org/W2048908304","doi":"https://doi.org/10.1142/s0218213012500273","title":"GAPPI: IDENTIFYING IMPORTANT PROTEIN MODULES THROUGH PROTEIN-PROTEIN INTERACTION GRAPHS","display_name":"GAPPI: IDENTIFYING IMPORTANT PROTEIN MODULES THROUGH PROTEIN-PROTEIN INTERACTION GRAPHS","publication_year":2012,"publication_date":"2012-05-03","ids":{"openalex":"https://openalex.org/W2048908304","doi":"https://doi.org/10.1142/s0218213012500273","mag":"2048908304"},"language":"en","primary_location":{"id":"doi:10.1142/s0218213012500273","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218213012500273","pdf_url":null,"source":{"id":"https://openalex.org/S178780388","display_name":"International Journal of Artificial Intelligence Tools","issn_l":"0218-2130","issn":["0218-2130","1793-6349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal on Artificial Intelligence Tools","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021432827","display_name":"Charalampos Moschopoulos","orcid":null},"institutions":[{"id":"https://openalex.org/I206127235","display_name":"Academy of Athens","ror":"https://ror.org/00qsdn986","country_code":"GR","type":"education","lineage":["https://openalex.org/I206127235"]},{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"CHARALAMPOS MOSCHOPOULOS","raw_affiliation_strings":["Bioinformatics & Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens GR-11527, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics & Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens GR-11527, Greece","institution_ids":["https://openalex.org/I206127235","https://openalex.org/I4210093138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041427787","display_name":"MARIOS FYTROS","orcid":null},"institutions":[{"id":"https://openalex.org/I122380217","display_name":"Technological Educational Institute of Piraeus","ror":"https://ror.org/00ks0ea23","country_code":"GR","type":"education","lineage":["https://openalex.org/I122380217"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"MARIOS FYTROS","raw_affiliation_strings":["Computer System Department, Technological Institution of Piraeus, Petrou Ralli & Thivon 250, Aigaleo, Piraeus GR-11244, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer System Department, Technological Institution of Piraeus, Petrou Ralli & Thivon 250, Aigaleo, Piraeus GR-11244, Greece","institution_ids":["https://openalex.org/I122380217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025072987","display_name":"Stamatis Alatsathianos","orcid":null},"institutions":[{"id":"https://openalex.org/I122380217","display_name":"Technological Educational Institute of Piraeus","ror":"https://ror.org/00ks0ea23","country_code":"GR","type":"education","lineage":["https://openalex.org/I122380217"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"STAMATIS ALATSATHIANOS","raw_affiliation_strings":["Computer System Department, Technological Institution of Piraeus, Petrou Ralli & Thivon 250, Aigaleo, Piraeus GR-11244, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer System Department, Technological Institution of Piraeus, Petrou Ralli & Thivon 250, Aigaleo, Piraeus GR-11244, Greece","institution_ids":["https://openalex.org/I122380217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023124482","display_name":"Spiridon Likothanassis","orcid":"https://orcid.org/0000-0002-6212-6632"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"SPIRIDON LIKOTHANASSIS","raw_affiliation_strings":["Department of Computer Engineering & Informatics, University of Patras, Rio GR-26500, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering & Informatics, University of Patras, Rio GR-26500, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052164166","display_name":"\u03a3\u03bf\u03c6\u03af\u03b1 \u039a\u03bf\u03c3\u03c3\u03af\u03b4\u03b1","orcid":"https://orcid.org/0000-0002-8841-2864"},"institutions":[{"id":"https://openalex.org/I206127235","display_name":"Academy of Athens","ror":"https://ror.org/00qsdn986","country_code":"GR","type":"education","lineage":["https://openalex.org/I206127235"]},{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"SOPHIA KOSSIDA","raw_affiliation_strings":["Bioinformatics & Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens GR-11527, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics & Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens GR-11527, Greece","institution_ids":["https://openalex.org/I206127235","https://openalex.org/I4210093138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1324,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51678623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"21","issue":"06","first_page":"1250027","last_page":"1250027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9835000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.9033137559890747},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6189520359039307},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.44220975041389465},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4366236925125122},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.4148402810096741},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3178460896015167},{"id":"https://openalex.org/keywords/parallel-computing","display_name":"Parallel computing","score":0.10507377982139587}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.9033137559890747},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6189520359039307},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.44220975041389465},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4366236925125122},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4148402810096741},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3178460896015167},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.10507377982139587},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0218213012500273","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218213012500273","pdf_url":null,"source":{"id":"https://openalex.org/S178780388","display_name":"International Journal of Artificial Intelligence Tools","issn_l":"0218-2130","issn":["0218-2130","1793-6349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal on Artificial Intelligence Tools","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W156213059","https://openalex.org/W1519734172","https://openalex.org/W1635771532","https://openalex.org/W1978690156","https://openalex.org/W2012852001","https://openalex.org/W2047693963","https://openalex.org/W2050721857","https://openalex.org/W2075900721","https://openalex.org/W2078389146","https://openalex.org/W2084619201","https://openalex.org/W2095177499","https://openalex.org/W2106876741","https://openalex.org/W2116117181","https://openalex.org/W2121507105","https://openalex.org/W2124166542","https://openalex.org/W2138003801","https://openalex.org/W2152495216","https://openalex.org/W2155320925","https://openalex.org/W2158534713","https://openalex.org/W2167869241","https://openalex.org/W3100336949"],"related_works":["https://openalex.org/W2804364458","https://openalex.org/W4298130764","https://openalex.org/W2132641928","https://openalex.org/W4310225030","https://openalex.org/W2090259340","https://openalex.org/W2393816671","https://openalex.org/W2158836806","https://openalex.org/W2083665254","https://openalex.org/W1926736923","https://openalex.org/W2942177010"],"abstract_inverted_index":{"In":[0],"this":[1],"paper":[2],"a":[3,100],"new":[4],"Genetic":[5],"Algorithm":[6],"is":[7,84],"proposed,":[8],"called":[9],"GAppi,":[10],"which":[11],"performs":[12],"clustering":[13],"in":[14,50],"protein-protein":[15],"interaction":[16,35],"networks":[17],"to":[18,52,70,77],"identify":[19],"protein":[20,34],"complexes.":[21],"The":[22],"algorithm":[23],"has":[24,42,104],"been":[25,43,105],"tested":[26],"exhaustively":[27],"with":[28,45],"experimental":[29],"datasets":[30],"coming":[31],"from":[32,74],"online":[33],"databases":[36],"and":[37,40,56,65],"individual":[38],"experiments":[39],"it":[41,83,86],"compared":[44,69],"five":[46],"other":[47,71],"effective":[48],"techniques":[49],"order":[51],"demonstrate":[53],"its":[54,78],"efficiency":[55],"superior":[57],"performance.":[58],"Results":[59],"showed":[60],"that":[61,107],"GAppi":[62],"produces":[63],"feasible":[64],"very":[66],"efficient":[67],"solutions":[68],"techniques.":[72],"Except":[73],"that,":[75],"due":[76],"adaptive":[79],"behavior,":[80],"each":[81,97],"time":[82],"used":[85],"can":[87],"satisfy":[88],"different":[89,94],"constraints,":[90],"thus":[91],"meeting":[92],"the":[93,109],"needs":[95],"of":[96],"user.":[98],"Furthermore,":[99],"user":[101],"friendly":[102],"interface":[103],"implemented":[106],"hosts":[108],"proposed":[110],"algorithmic":[111],"strategy.":[112]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}