{"id":"https://openalex.org/W2016103819","doi":"https://doi.org/10.1142/s0218213010000182","title":"ON THE DESIGN OF OPTIMIZATION ALGORITHMS FOR PREDICTION OF MOLECULAR INTERACTIONS","display_name":"ON THE DESIGN OF OPTIMIZATION ALGORITHMS FOR PREDICTION OF MOLECULAR INTERACTIONS","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W2016103819","doi":"https://doi.org/10.1142/s0218213010000182","mag":"2016103819"},"language":"en","primary_location":{"id":"doi:10.1142/s0218213010000182","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218213010000182","pdf_url":null,"source":{"id":"https://openalex.org/S178780388","display_name":"International Journal of Artificial Intelligence Tools","issn_l":"0218-2130","issn":["0218-2130","1793-6349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal on Artificial Intelligence Tools","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059145234","display_name":"Darby Tien-Hao Chang","orcid":"https://orcid.org/0000-0001-9119-4231"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"DARBY TIEN-HAO CHANG","raw_affiliation_strings":["Department of Electrical Engineering, National Cheng Kung University, Tainan, 70101, Taiwan","Department of Electrical Engineering, National Cheng Kung University, Tainan 70101, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, National Cheng Kung University, Tainan, 70101, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Electrical Engineering, National Cheng Kung University, Tainan 70101, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075779650","display_name":"Jung\u2010Hsin Lin","orcid":"https://orcid.org/0000-0002-6712-4994"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"JUNG-HSIN LIN","raw_affiliation_strings":["Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, Taipei 115, Taiwan","School of Pharmacy, College of Medicine, National Taiwan University, Taipei 106, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I84653119"]},{"raw_affiliation_string":"School of Pharmacy, College of Medicine, National Taiwan University, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111660668","display_name":"Chih-Hung Hsieh","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"CHIH-HUNG HSIEH","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan","Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan,","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000658840","display_name":"YEN-JENG OYANG","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"YEN-JENG OYANG","raw_affiliation_strings":["Center for Systems Biology and Bioinformatics, National Taiwan University, Taipei 106, Taiwan","Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan","Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan","Graduate Institute of Networking and Multimedia, National Taiwan University, Taipei 106, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology and Bioinformatics, National Taiwan University, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Networking and Multimedia, National Taiwan University, Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3324,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.67741358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"03","first_page":"267","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.8054100275039673},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.5804688334465027},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.48933809995651245},{"id":"https://openalex.org/keywords/optimization-algorithm","display_name":"Optimization algorithm","score":0.48375391960144043},{"id":"https://openalex.org/keywords/optimization-problem","display_name":"Optimization problem","score":0.47809645533561707},{"id":"https://openalex.org/keywords/evolutionary-algorithm","display_name":"Evolutionary algorithm","score":0.4325951635837555},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.4283609092235565},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3223855495452881},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2651384174823761},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.24363964796066284},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09080874919891357}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8054100275039673},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.5804688334465027},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.48933809995651245},{"id":"https://openalex.org/C2987595161","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Optimization algorithm","level":2,"score":0.48375391960144043},{"id":"https://openalex.org/C137836250","wikidata":"https://www.wikidata.org/wiki/Q984063","display_name":"Optimization problem","level":2,"score":0.47809645533561707},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.4325951635837555},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.4283609092235565},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3223855495452881},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2651384174823761},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.24363964796066284},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09080874919891357}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0218213010000182","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218213010000182","pdf_url":null,"source":{"id":"https://openalex.org/S178780388","display_name":"International Journal of Artificial Intelligence Tools","issn_l":"0218-2130","issn":["0218-2130","1793-6349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal on Artificial Intelligence Tools","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1659842140","https://openalex.org/W1986240377","https://openalex.org/W2009297402","https://openalex.org/W2014461019","https://openalex.org/W2072759559","https://openalex.org/W2091734240","https://openalex.org/W2094795801","https://openalex.org/W2111796195","https://openalex.org/W2121895929","https://openalex.org/W2144729032","https://openalex.org/W2145010489","https://openalex.org/W2145682943","https://openalex.org/W2158534713","https://openalex.org/W3023540311"],"related_works":["https://openalex.org/W4296209631","https://openalex.org/W2561617217","https://openalex.org/W2382364780","https://openalex.org/W2073248645","https://openalex.org/W2022485595","https://openalex.org/W2362147779","https://openalex.org/W3212179065","https://openalex.org/W2184070258","https://openalex.org/W3087997050","https://openalex.org/W2348923905"],"abstract_inverted_index":{"This":[0,97,163],"article":[1,164],"presents":[2],"a":[3,11,29,77,129],"comprehensive":[4],"study":[5,98],"on":[6],"the":[7,39,59,64,68,73,103,106,124,137,151,159,171,174,186],"main":[8],"characteristics":[9],"of":[10,19,24,47,63,72,118,142,150,173],"novel":[12],"optimization":[13,25,79,112,126],"algorithm":[14,113,139,153,188],"specifically":[15,114],"designed":[16,85,115],"for":[17,37,116,184],"simulation":[18,46,117],"protein-ligand":[20,48,119],"interactions.":[21],"Though":[22],"design":[23],"algorithms":[26,80,127],"has":[27,99,121],"been":[28,100],"research":[30],"issue":[31],"extensively":[32],"studied":[33],"by":[34,102,128],"computer":[35],"scientists":[36],"decades,":[38],"emerging":[40],"applications":[41],"in":[42,154,158],"bioinformatics":[43],"such":[44],"as":[45],"interactions":[49],"and":[50,66],"protein":[51],"folding":[52],"introduce":[53],"additional":[54],"challenges":[55,90],"due":[56],"to":[57,86,93,146,169,193],"(1)":[58],"high":[60],"dimensionality":[61],"nature":[62],"problem":[65],"(2)":[67],"highly":[69],"rugged":[70],"landscape":[71],"energy":[74],"function.":[75],"As":[76],"result,":[78],"that":[81,105,136],"are":[82],"not":[83],"carefully":[84],"tackle":[87,194],"these":[88],"two":[89],"may":[91],"fail":[92],"deliver":[94],"satisfactory":[95],"performance.":[96],"motivated":[101],"observation":[104],"RAME":[107,138],"(Rank-based":[108],"Adaptive":[109],"Mutation":[110],"Evolutionary)":[111],"docking":[120],"consistently":[122],"outperformed":[123],"conventional":[125],"significant":[130],"degree.":[131],"The":[132,178],"experimental":[133],"results":[134],"reveal":[135],"is":[140],"capable":[141],"delivering":[143],"superior":[144],"performance":[145,176],"several":[147],"alternative":[148],"versions":[149],"genetic":[152],"handling":[155],"highly-rugged":[156],"functions":[157],"high-dimensional":[160],"vector":[161],"space.":[162],"also":[165],"reports":[166],"experiments":[167],"conducted":[168],"analyze":[170],"causes":[172],"observed":[175],"difference.":[177],"experiences":[179],"learned":[180],"provide":[181],"valuable":[182],"clues":[183],"how":[185],"proposed":[187],"can":[189],"be":[190],"effectively":[191],"exploited":[192],"other":[195],"computational":[196],"biology":[197],"problems.":[198]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}