{"id":"https://openalex.org/W2283777338","doi":"https://doi.org/10.1142/s0218127416500164","title":"Characteristics of Promoter Architecture-Dependent Expression Noise and Bursting Kinetics","display_name":"Characteristics of Promoter Architecture-Dependent Expression Noise and Bursting Kinetics","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2283777338","doi":"https://doi.org/10.1142/s0218127416500164","mag":"2283777338"},"language":"en","primary_location":{"id":"doi:10.1142/s0218127416500164","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127416500164","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055248633","display_name":"Heli Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Heli Tan","raw_affiliation_strings":["School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109591222","display_name":"Zhanjiang Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhanjiang Yuan","raw_affiliation_strings":["School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319576","display_name":"Jiajun Zhang","orcid":"https://orcid.org/0000-0001-7107-4814"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajun Zhang","raw_affiliation_strings":["School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039634984","display_name":"Tianshou Zhou","orcid":"https://orcid.org/0000-0002-0797-0531"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianshou Zhou","raw_affiliation_strings":["School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055248633"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00446974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"01","first_page":"1650016","last_page":"1650016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9739999771118164,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bursting","display_name":"Bursting","score":0.9574733972549438},{"id":"https://openalex.org/keywords/counterintuitive","display_name":"Counterintuitive","score":0.6634979844093323},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.5436049103736877},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5317396521568298},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5124986171722412},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4993877410888672},{"id":"https://openalex.org/keywords/kinetics","display_name":"Kinetics","score":0.496695339679718},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4870944023132324},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.4587900638580322},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4575878381729126},{"id":"https://openalex.org/keywords/master-regulator","display_name":"Master regulator","score":0.45182886719703674},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.4443700313568115},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.401904433965683},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4004228115081787},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35626357793807983},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.34372156858444214},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.27203571796417236},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1647227704524994},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.16212454438209534},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.0830305814743042},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.07553631067276001}],"concepts":[{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.9574733972549438},{"id":"https://openalex.org/C101097943","wikidata":"https://www.wikidata.org/wiki/Q5176983","display_name":"Counterintuitive","level":2,"score":0.6634979844093323},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5436049103736877},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5317396521568298},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5124986171722412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4993877410888672},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.496695339679718},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4870944023132324},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4587900638580322},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4575878381729126},{"id":"https://openalex.org/C3017607883","wikidata":"https://www.wikidata.org/wiki/Q25325354","display_name":"Master regulator","level":4,"score":0.45182886719703674},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4443700313568115},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.401904433965683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4004228115081787},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35626357793807983},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.34372156858444214},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.27203571796417236},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1647227704524994},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16212454438209534},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0830305814743042},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.07553631067276001},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0218127416500164","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127416500164","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/11","display_name":"Sustainable cities and communities"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1531414226","https://openalex.org/W1964261044","https://openalex.org/W1970970926","https://openalex.org/W1984429906","https://openalex.org/W1988791304","https://openalex.org/W2003499939","https://openalex.org/W2014731896","https://openalex.org/W2016780506","https://openalex.org/W2016897864","https://openalex.org/W2018317221","https://openalex.org/W2031822229","https://openalex.org/W2037685552","https://openalex.org/W2039569152","https://openalex.org/W2040889971","https://openalex.org/W2042194987","https://openalex.org/W2043487490","https://openalex.org/W2043562679","https://openalex.org/W2044692345","https://openalex.org/W2054331129","https://openalex.org/W2063177229","https://openalex.org/W2066415979","https://openalex.org/W2067432938","https://openalex.org/W2077046573","https://openalex.org/W2080252570","https://openalex.org/W2080722161","https://openalex.org/W2081382181","https://openalex.org/W2081434722","https://openalex.org/W2089904810","https://openalex.org/W2091198609","https://openalex.org/W2103354991","https://openalex.org/W2104223513","https://openalex.org/W2109936378","https://openalex.org/W2110612987","https://openalex.org/W2110690451","https://openalex.org/W2113324803","https://openalex.org/W2114870653","https://openalex.org/W2118274513","https://openalex.org/W2120510361","https://openalex.org/W2124055046","https://openalex.org/W2127013070","https://openalex.org/W2132471558","https://openalex.org/W2141688036","https://openalex.org/W2148323109","https://openalex.org/W2149242848","https://openalex.org/W2151294425","https://openalex.org/W2154249152","https://openalex.org/W2155418451","https://openalex.org/W2167244112","https://openalex.org/W2171425427","https://openalex.org/W2171769276","https://openalex.org/W2330395334","https://openalex.org/W2787895155","https://openalex.org/W2964322029"],"related_works":["https://openalex.org/W2612276045","https://openalex.org/W1515479003","https://openalex.org/W4361820636","https://openalex.org/W4313379347","https://openalex.org/W3036794625","https://openalex.org/W4367848389","https://openalex.org/W2392679852","https://openalex.org/W2363047424","https://openalex.org/W2142077462","https://openalex.org/W2120231674"],"abstract_inverted_index":{"Genes":[0],"are":[1,79,148],"expressed":[2],"often":[3],"in":[4,12,82,91,121,131,140,169],"a":[5,56],"bursting":[6,32,119],"manner,":[7],"leading":[8],"to":[9,26,123],"stochastic":[10],"fluctuations":[11],"mRNA":[13],"and":[14,21,31,41,49,64,74,99],"protein":[15],"abundances,":[16],"but":[17,85],"how":[18,177],"the":[19,46,50,76,83,88,92,97,124,129,132,145,157],"binding":[20],"unbinding":[22],"of":[23,115,160,166],"transcriptional":[24],"factors":[25,179],"DNA":[27],"affect":[28],"expression":[29,116,182],"noise":[30,117],"kinetics":[33,120],"remains":[34],"not":[35],"fully":[36],"understood.":[37],"Here,":[38],"we":[39],"compare":[40],"analyze":[42],"two":[43,65,73,109],"representative":[44],"cases:":[45],"(E)":[47,133],"model":[48,134],"(M)":[51,141],"model,":[52,142],"each":[53],"assuming":[54],"that":[55,75,96,139,144],"gene":[57,105,181],"has":[58],"three":[59],"activity":[60],"states":[61,78],"(one":[62],"active":[63,89],"inactive":[66,77],"states)":[67],"with":[68,118],"dual":[69],"transitions":[70],"between":[71],"every":[72],"directly":[80],"linked":[81],"former":[84],"separated":[86],"by":[87],"state":[90],"latter.":[93],"We":[94],"find":[95],"activation":[98],"inactivation":[100],"rates":[101,110],"can":[102,111],"significantly":[103],"impact":[104],"expression.":[106],"First,":[107],"these":[108],"induce":[112],"counterintuitive":[113,146],"correlations":[114],"contrast":[122],"common":[125],"two-state":[126],"model.":[127],"Second,":[128],"correlation":[130],"is":[135],"fundamentally":[136],"different":[137],"from":[138],"implying":[143],"phenomena":[147],"regulator-specific.":[149],"Our":[150],"investigation":[151],"primarily":[152],"gives":[153],"us":[154],"insight":[155],"into":[156,176],"design":[158],"principles":[159],"promoter":[161],"architecture":[162],"(a":[163],"major":[164],"source":[165],"cell-to-cell":[167],"variability":[168],"genetically":[170],"identical":[171],"cells)":[172],"as":[173,175],"well":[174],"transcription":[178],"influence":[180],"through":[183],"regulating":[184],"transition":[185],"rates.":[186]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}