{"id":"https://openalex.org/W1973388222","doi":"https://doi.org/10.1142/s0218127413501381","title":"STABILITY OF REGULATORY PROTEIN GRADIENTS INDUCED BY MORPHOGEN DPP IN <i>DROSOPHILA</i> WING DISC","display_name":"STABILITY OF REGULATORY PROTEIN GRADIENTS INDUCED BY MORPHOGEN DPP IN <i>DROSOPHILA</i> WING DISC","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W1973388222","doi":"https://doi.org/10.1142/s0218127413501381","mag":"1973388222"},"language":"en","primary_location":{"id":"doi:10.1142/s0218127413501381","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127413501381","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030656446","display_name":"Hongwei Yin","orcid":"https://orcid.org/0000-0001-6647-1153"},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"HONGWEI YIN","raw_affiliation_strings":["School of Science, Nanchang University, Nanchang 330031, P. R. China","School of Science, Nanchang University, Nanchang 330031, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Science, Nanchang University, Nanchang 330031, P. R. China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"School of Science, Nanchang University, Nanchang 330031, P.R. China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087779662","display_name":"Xiao\u2010Yong Xiao","orcid":"https://orcid.org/0000-0003-2506-269X"},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIAOYONG XIAO","raw_affiliation_strings":["School of Science, Nanchang University, Nanchang 330031, P. R. China","School of Science, Nanchang University, Nanchang 330031, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Science, Nanchang University, Nanchang 330031, P. R. China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"School of Science, Nanchang University, Nanchang 330031, P.R. China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101468301","display_name":"Xiaoqing Wen","orcid":"https://orcid.org/0000-0001-7448-7104"},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIAOQING WEN","raw_affiliation_strings":["School of Science, Nanchang University, Nanchang 330031, P. R. China","School of Science, Nanchang University, Nanchang 330031, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Science, Nanchang University, Nanchang 330031, P. R. China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"School of Science, Nanchang University, Nanchang 330031, P.R. China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039634984","display_name":"Tianshou Zhou","orcid":"https://orcid.org/0000-0002-0797-0531"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"TIANSHOU ZHOU","raw_affiliation_strings":["School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, P. R. China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030656446"],"corresponding_institution_ids":["https://openalex.org/I141649914"],"apc_list":null,"apc_paid":null,"fwci":0.2754,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.51686282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"23","issue":"08","first_page":"1350138","last_page":"1350138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphogen","display_name":"Morphogen","score":0.9786306619644165},{"id":"https://openalex.org/keywords/wing","display_name":"Wing","score":0.84113609790802},{"id":"https://openalex.org/keywords/decapentaplegic","display_name":"Decapentaplegic","score":0.6278723478317261},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.584148645401001},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5570731163024902},{"id":"https://openalex.org/keywords/gap-gene","display_name":"Gap gene","score":0.4957045316696167},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.48927924036979675},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.48393017053604126},{"id":"https://openalex.org/keywords/regulator-gene","display_name":"Regulator gene","score":0.48093289136886597},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila (subgenus)","score":0.45825257897377014},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.43582743406295776},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.36332476139068604},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.36113062500953674},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3286161422729492},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29348239302635193},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20768463611602783},{"id":"https://openalex.org/keywords/imaginal-disc","display_name":"Imaginal disc","score":0.1413687765598297},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1346653401851654},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.11118555068969727}],"concepts":[{"id":"https://openalex.org/C2778386714","wikidata":"https://www.wikidata.org/wiki/Q417084","display_name":"Morphogen","level":3,"score":0.9786306619644165},{"id":"https://openalex.org/C97257150","wikidata":"https://www.wikidata.org/wiki/Q161358","display_name":"Wing","level":2,"score":0.84113609790802},{"id":"https://openalex.org/C2776735322","wikidata":"https://www.wikidata.org/wiki/Q976767","display_name":"Decapentaplegic","level":5,"score":0.6278723478317261},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.584148645401001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5570731163024902},{"id":"https://openalex.org/C184937244","wikidata":"https://www.wikidata.org/wiki/Q410820","display_name":"Gap gene","level":4,"score":0.4957045316696167},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.48927924036979675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48393017053604126},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.48093289136886597},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.45825257897377014},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.43582743406295776},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.36332476139068604},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.36113062500953674},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3286161422729492},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29348239302635193},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20768463611602783},{"id":"https://openalex.org/C91986751","wikidata":"https://www.wikidata.org/wiki/Q996011","display_name":"Imaginal disc","level":4,"score":0.1413687765598297},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1346653401851654},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.11118555068969727},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0218127413501381","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127413501381","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1720193968","https://openalex.org/W1964350862","https://openalex.org/W1965558704","https://openalex.org/W1971127837","https://openalex.org/W1982169021","https://openalex.org/W1993217285","https://openalex.org/W1994606684","https://openalex.org/W1994844861","https://openalex.org/W1998746265","https://openalex.org/W2000163865","https://openalex.org/W2012794478","https://openalex.org/W2018857251","https://openalex.org/W2022620053","https://openalex.org/W2026334398","https://openalex.org/W2037921918","https://openalex.org/W2038981297","https://openalex.org/W2041892053","https://openalex.org/W2044341058","https://openalex.org/W2046145946","https://openalex.org/W2049529576","https://openalex.org/W2055541363","https://openalex.org/W2071199204","https://openalex.org/W2079385876","https://openalex.org/W2082844529","https://openalex.org/W2084318376","https://openalex.org/W2084435116","https://openalex.org/W2085476962","https://openalex.org/W2089171051","https://openalex.org/W2089460976","https://openalex.org/W2108193392","https://openalex.org/W2122407134","https://openalex.org/W2125307802","https://openalex.org/W2127940208","https://openalex.org/W2128584428","https://openalex.org/W2149921245","https://openalex.org/W2163569157","https://openalex.org/W2166968747","https://openalex.org/W2167657345","https://openalex.org/W2170106551"],"related_works":["https://openalex.org/W1997341464","https://openalex.org/W2092728011","https://openalex.org/W4252172641","https://openalex.org/W4205466919","https://openalex.org/W2022620053","https://openalex.org/W4251124705","https://openalex.org/W2071532459","https://openalex.org/W2585976138","https://openalex.org/W2049977953","https://openalex.org/W1973388222"],"abstract_inverted_index":{"In":[0,96],"the":[1,37,58,61,70,74,78,99,106,116],"development":[2],"of":[3,60,64,73,81,109,115,118],"Drosophila":[4],"wing":[5,75],"disc,":[6],"morphogen":[7],"Dpp,":[8],"which":[9,49],"is":[10,102],"a":[11,15,27],"signaling":[12,54],"molecule":[13],"from":[14],"local":[16],"region":[17],"and":[18,22,43,45,56,68,87,93],"disperses":[19],"into":[20],"anterior":[21],"posterior":[23],"compartments,":[24],"builds":[25],"up":[26],"gradient":[28],"with":[29,90,133],"precise":[30],"pattern":[31,72],"information.":[32],"Experiments":[33],"have":[34],"demonstrated":[35],"that":[36,128],"key":[38,111],"genes":[39,83],"(brk,":[40],"dad,":[41],"omb":[42],"sal)":[44],"phosphorylated":[46],"protein":[47],"(pMad),":[48],"are":[50,84,122,131],"activated":[51],"by":[52],"Dpp":[53],"molecules":[55],"form":[57],"gradients":[59,117,130],"corresponding":[62,120],"proteins":[63,121],"these":[65,82,110,119,129],"genes,":[66],"direct":[67],"control":[69],"spatial":[71],"disc.":[76],"However,":[77],"regulatory":[79,107,142],"network":[80],"in":[85,140],"complex":[86],"nonlinear":[88],"interaction":[89],"upstream":[91],"regulators":[92],"downstream":[94],"targets.":[95],"this":[97,141],"paper,":[98],"mathematical":[100],"model":[101],"built":[103],"according":[104],"to":[105,135],"relationships":[108],"genes.":[112],"The":[113],"stabilities":[114],"investigated.":[123],"Furthermore,":[124],"numerical":[125],"simulations":[126],"show":[127],"robust":[132],"respect":[134],"some":[136],"major":[137],"reaction":[138],"rates":[139],"network.":[143]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}