{"id":"https://openalex.org/W2114551916","doi":"https://doi.org/10.1142/s0218127407017355","title":"SUPPRESSION OF CELLULAR ALTERNANS IN GUINEA PIG VENTRICULAR MYOCYTES WITH LQT2: INSIGHTS FROM THE LUO\u2013RUDY MODEL","display_name":"SUPPRESSION OF CELLULAR ALTERNANS IN GUINEA PIG VENTRICULAR MYOCYTES WITH LQT2: INSIGHTS FROM THE LUO\u2013RUDY MODEL","publication_year":2007,"publication_date":"2007-02-01","ids":{"openalex":"https://openalex.org/W2114551916","doi":"https://doi.org/10.1142/s0218127407017355","mag":"2114551916"},"language":"en","primary_location":{"id":"doi:10.1142/s0218127407017355","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127407017355","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005670100","display_name":"Vladimir E. Bondarenko","orcid":"https://orcid.org/0000-0003-4356-4669"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"VLADIMIR E. BONDARENKO","raw_affiliation_strings":["Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 124 Sherman Hall, 3435 Main Street, Buffalo, NY 14214-3078, USA"],"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 124 Sherman Hall, 3435 Main Street, Buffalo, NY 14214-3078, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109115329","display_name":"Randall L. Rasmusson","orcid":null},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RANDALL L. RASMUSSON","raw_affiliation_strings":["Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 124 Sherman Hall, 3435 Main Street, Buffalo, NY 14214-3078, USA"],"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 124 Sherman Hall, 3435 Main Street, Buffalo, NY 14214-3078, USA","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005670100"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":null,"apc_paid":null,"fwci":0.5904,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72744334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"02","first_page":"381","last_page":"425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.904699981212616,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.7489104270935059},{"id":"https://openalex.org/keywords/herg","display_name":"hERG","score":0.6059914827346802},{"id":"https://openalex.org/keywords/myocyte","display_name":"Myocyte","score":0.4914957284927368},{"id":"https://openalex.org/keywords/heart-block","display_name":"Heart block","score":0.4797733724117279},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4646463096141815},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"Long QT syndrome","score":0.43380555510520935},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"Ventricular fibrillation","score":0.4243849515914917},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.419746458530426},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3965870440006256},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31117212772369385},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.25756335258483887},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.2568392753601074},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.219832181930542},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.1743718385696411}],"concepts":[{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.7489104270935059},{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.6059914827346802},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4914957284927368},{"id":"https://openalex.org/C2776661526","wikidata":"https://www.wikidata.org/wiki/Q1361515","display_name":"Heart block","level":3,"score":0.4797733724117279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4646463096141815},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.43380555510520935},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.4243849515914917},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.419746458530426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3965870440006256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31117212772369385},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.25756335258483887},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.2568392753601074},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.219832181930542},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.1743718385696411}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0218127407017355","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127407017355","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":166,"referenced_works":["https://openalex.org/W22184475","https://openalex.org/W34774160","https://openalex.org/W70460126","https://openalex.org/W156394551","https://openalex.org/W220488953","https://openalex.org/W1478261329","https://openalex.org/W1489387013","https://openalex.org/W1521731378","https://openalex.org/W1632776070","https://openalex.org/W1964007908","https://openalex.org/W1964047030","https://openalex.org/W1966730613","https://openalex.org/W1967658895","https://openalex.org/W1968098810","https://openalex.org/W1971144028","https://openalex.org/W1972786555","https://openalex.org/W1976086141","https://openalex.org/W1976588153","https://openalex.org/W1982883262","https://openalex.org/W1984621339","https://openalex.org/W1986023817","https://openalex.org/W1988727934","https://openalex.org/W1988998632","https://openalex.org/W1989442233","https://openalex.org/W1989775219","https://openalex.org/W1991425961","https://openalex.org/W1991662012","https://openalex.org/W1994666309","https://openalex.org/W1995005951","https://openalex.org/W1995033447","https://openalex.org/W1995109939","https://openalex.org/W2001326386","https://openalex.org/W2002475547","https://openalex.org/W2002854419","https://openalex.org/W2003085731","https://openalex.org/W2003394756","https://openalex.org/W2004875888","https://openalex.org/W2007933379","https://openalex.org/W2008082177","https://openalex.org/W2009775227","https://openalex.org/W2013157031","https://openalex.org/W2017095658","https://openalex.org/W2019028325","https://openalex.org/W2019417284","https://openalex.org/W2019973925","https://openalex.org/W2020859911","https://openalex.org/W2021921746","https://openalex.org/W2021963728","https://openalex.org/W2022138433","https://openalex.org/W2023912703","https://openalex.org/W2025498083","https://openalex.org/W2025653513","https://openalex.org/W2028146834","https://openalex.org/W2028521745","https://openalex.org/W2031053544","https://openalex.org/W2032752149","https://openalex.org/W2033349029","https://openalex.org/W2034214746","https://openalex.org/W2035766144","https://openalex.org/W2037462241","https://openalex.org/W2038131479","https://openalex.org/W2039663129","https://openalex.org/W2040694429","https://openalex.org/W2044569996","https://openalex.org/W2045548568","https://openalex.org/W2046358687","https://openalex.org/W2047275378","https://openalex.org/W2050590316","https://openalex.org/W2051673088","https://openalex.org/W2051685732","https://openalex.org/W2052011489","https://openalex.org/W2054905500","https://openalex.org/W2057396267","https://openalex.org/W2057636417","https://openalex.org/W2058667675","https://openalex.org/W2058716064","https://openalex.org/W2059142008","https://openalex.org/W2060903567","https://openalex.org/W2062017475","https://openalex.org/W2065246793","https://openalex.org/W2065507922","https://openalex.org/W2067105882","https://openalex.org/W2069489777","https://openalex.org/W2070247169","https://openalex.org/W2070452180","https://openalex.org/W2070779934","https://openalex.org/W2072468148","https://openalex.org/W2073026156","https://openalex.org/W2074705578","https://openalex.org/W2075209232","https://openalex.org/W2077129671","https://openalex.org/W2081524260","https://openalex.org/W2082967245","https://openalex.org/W2084087354","https://openalex.org/W2084756418","https://openalex.org/W2085111748","https://openalex.org/W2086244276","https://openalex.org/W2086414114","https://openalex.org/W2088020365","https://openalex.org/W2088529499","https://openalex.org/W2089353550","https://openalex.org/W2093214695","https://openalex.org/W2094058963","https://openalex.org/W2094109994","https://openalex.org/W2094886506","https://openalex.org/W2097719530","https://openalex.org/W2098623700","https://openalex.org/W2100477955","https://openalex.org/W2104714866","https://openalex.org/W2108766809","https://openalex.org/W2111174244","https://openalex.org/W2112091653","https://openalex.org/W2112713043","https://openalex.org/W2115870475","https://openalex.org/W2115928923","https://openalex.org/W2116581628","https://openalex.org/W2119277805","https://openalex.org/W2119653736","https://openalex.org/W2120263248","https://openalex.org/W2121217634","https://openalex.org/W2121793138","https://openalex.org/W2127154973","https://openalex.org/W2128728321","https://openalex.org/W2129393568","https://openalex.org/W2131308754","https://openalex.org/W2132561989","https://openalex.org/W2132793029","https://openalex.org/W2134831745","https://openalex.org/W2135454160","https://openalex.org/W2135771733","https://openalex.org/W2137296128","https://openalex.org/W2138773108","https://openalex.org/W2139510409","https://openalex.org/W2139625233","https://openalex.org/W2144567173","https://openalex.org/W2146915062","https://openalex.org/W2148734617","https://openalex.org/W2150075279","https://openalex.org/W2150181546","https://openalex.org/W2150263819","https://openalex.org/W2150962221","https://openalex.org/W2151973555","https://openalex.org/W2156291625","https://openalex.org/W2156937709","https://openalex.org/W2157788198","https://openalex.org/W2159419580","https://openalex.org/W2161424604","https://openalex.org/W2162826334","https://openalex.org/W2166325927","https://openalex.org/W2170014849","https://openalex.org/W2171878126","https://openalex.org/W2329306090","https://openalex.org/W2334859129","https://openalex.org/W2395425468","https://openalex.org/W2406117726","https://openalex.org/W2408268551","https://openalex.org/W2442822067","https://openalex.org/W2463417997","https://openalex.org/W2580747944","https://openalex.org/W2616249537","https://openalex.org/W3105710497","https://openalex.org/W4248666415","https://openalex.org/W4251811303","https://openalex.org/W4293179290","https://openalex.org/W4390541499","https://openalex.org/W6611470503"],"related_works":["https://openalex.org/W2040918531","https://openalex.org/W2369460048","https://openalex.org/W1997071795","https://openalex.org/W3215962282","https://openalex.org/W2169618136","https://openalex.org/W2029811900","https://openalex.org/W2375901818","https://openalex.org/W2166609040","https://openalex.org/W2362307279","https://openalex.org/W2074705578"],"abstract_inverted_index":{"Genetic":[0],"and":[1,26,41,70,128,139,236],"drug-induced":[2],"abnormalities":[3],"of":[4,20,37,43,51,59,61,82,90,95,105,122,137,146,155,163,171,181,189,200,228,253,262,271],"cardiac":[5],"repolarization":[6,52],"have":[7],"been":[8],"linked":[9],"to":[10,102,125,149],"fatal":[11],"arrhythmias.":[12],"These":[13],"arrhythmias":[14],"result":[15],"from":[16],"a":[17,85,161,172,251],"complex":[18,135,152],"interaction":[19],"the":[21,62,74,80,116,120,144,156,224,260],"remaining":[22],"currents":[23,148,231],"during":[24,53],"excitation":[25],"repolarization.":[27],"In":[28],"this":[29,151],"review,":[30],"we":[31],"examine":[32],"recent":[33],"advancement":[34],"in":[35,244],"investigations":[36],"genetic":[38],"heart":[39],"diseases":[40],"mechanisms":[42,257],"arrhythmia":[44],"generation.":[45],"We":[46,142,255],"also":[47],"present":[48],"our":[49],"simulation":[50],"rapid":[54,63],"pacing":[55,242],"for":[56,119,129,158,269],"different":[57],"levels":[58,94],"block":[60,98,170,180],"delayed":[64],"rectifier":[65],"current,":[66,209,217],"I":[67,96,113],"Kr":[68,97,114],",":[69],"pharmacological":[71],"interventions":[72],"using":[73],"Luo\u2013Rudy":[75],"model.":[76],"Control":[77],"simulations":[78],"showed":[79,133],"development":[81,261],"alternans":[83,123,263],"at":[84,240],"basic":[86],"cycle":[87,131],"length":[88],"(BCL)":[89],"131":[91],"ms.":[92],"Two":[93],"were":[99],"simulated":[100],"corresponding":[101],"type":[103],"2":[104],"familial":[106],"long":[107],"QT":[108],"syndrome,":[109],"LQT2.":[110,274],"At":[111],"100%":[112,169],"block,":[115],"threshold":[117,157,225],"BCL":[118,164],"appearance":[121],"increased":[124,205,223],"145":[126],"ms":[127],"shorter":[130],"lengths":[132],"increasingly":[134],"patterns":[136],"periodic":[138],"chaotic":[140,237],"behavior.":[141,153],"examined":[143],"potential":[145],"other":[147,230],"correct":[150],"Improvement":[154],"bifurcation":[159],"as":[160],"function":[162],"was":[165],"achieved":[166],"by:":[167],"(1)":[168],"nonspecific":[173],"Ca":[174,183,207],"2+":[175,184,208],"-activated":[176],"current;":[177,185,196],"(2)":[178],"15%":[179],"L-type":[182,206],"(3)":[186],"20%":[187],"increase":[188,199],"Na":[190,211],"+":[191,194,212,215],"/":[192,213],"K":[193,214],"pump":[195,202,216,221],"(4)":[197],"50%":[198],"SERCA2":[201,220],"activity.":[203],"Conversely,":[204],"decreased":[210,219],"or":[218],"activity":[222,238],"BCL.":[226],"Modification":[227],"several":[229],"had":[232],"little":[233],"effect.":[234],"Alternans":[235],"develop":[239],"fast":[241],"rates":[243],"model":[245],"guinea":[246],"pig":[247],"ventricular":[248],"myocytes":[249],"through":[250],"sequence":[252],"bifurcations.":[254],"elucidated":[256],"that":[258],"modify":[259],"which":[264],"may":[265],"provide":[266],"novel":[267],"targets":[268],"treatment":[270],"patients":[272],"with":[273]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
