{"id":"https://openalex.org/W2008882415","doi":"https://doi.org/10.1142/s0218127405012636","title":"ROBUST DEPENDENCIES AND STRUCTURES IN STEM CELL DIFFERENTIATION","display_name":"ROBUST DEPENDENCIES AND STRUCTURES IN STEM CELL DIFFERENTIATION","publication_year":2005,"publication_date":"2005-04-01","ids":{"openalex":"https://openalex.org/W2008882415","doi":"https://doi.org/10.1142/s0218127405012636","mag":"2008882415"},"language":"en","primary_location":{"id":"doi:10.1142/s0218127405012636","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127405012636","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074779940","display_name":"Radhakrishnan Nagarajan","orcid":"https://orcid.org/0000-0001-8564-681X"},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RADHAKRISHNAN NAGARAJAN","raw_affiliation_strings":["Center on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021498680","display_name":"Jane E. Aubin","orcid":"https://orcid.org/0000-0002-7268-5235"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"JANE E. AUBIN","raw_affiliation_strings":["Department of Medical Genetics and Microbiology, University of Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics and Microbiology, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088076188","display_name":"Charlotte A. Peterson","orcid":"https://orcid.org/0000-0001-9340-0705"},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHARLOTTE A. PETERSON","raw_affiliation_strings":["Center on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","Central Arkansas Veterans Health Care System, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Central Arkansas Veterans Health Care System, USA","institution_ids":["https://openalex.org/I4210099013"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.080245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"15","issue":"04","first_page":"1503","last_page":"1514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.6860981583595276},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.6780255436897278},{"id":"https://openalex.org/keywords/functional-dependency","display_name":"Functional dependency","score":0.6125869750976562},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5190201997756958},{"id":"https://openalex.org/keywords/observable","display_name":"Observable","score":0.5077356100082397},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.5015914440155029},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.4733286499977112},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.4652456045150757},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.4449288845062256},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4319098889827728},{"id":"https://openalex.org/keywords/transfer-entropy","display_name":"Transfer entropy","score":0.4304627478122711},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.42225754261016846},{"id":"https://openalex.org/keywords/dependency","display_name":"Dependency (UML)","score":0.4182285964488983},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.41664621233940125},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.36435848474502563},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3529123067855835},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.32241642475128174},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3030714988708496},{"id":"https://openalex.org/keywords/principle-of-maximum-entropy","display_name":"Principle of maximum entropy","score":0.2870662212371826},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2586780786514282},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24448928236961365},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18895000219345093},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1674804389476776},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11975300312042236}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.6860981583595276},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.6780255436897278},{"id":"https://openalex.org/C26320393","wikidata":"https://www.wikidata.org/wiki/Q597053","display_name":"Functional dependency","level":3,"score":0.6125869750976562},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5190201997756958},{"id":"https://openalex.org/C32848918","wikidata":"https://www.wikidata.org/wiki/Q845789","display_name":"Observable","level":2,"score":0.5077356100082397},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.5015914440155029},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.4733286499977112},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.4652456045150757},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.4449288845062256},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4319098889827728},{"id":"https://openalex.org/C182049051","wikidata":"https://www.wikidata.org/wiki/Q17147155","display_name":"Transfer entropy","level":3,"score":0.4304627478122711},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.42225754261016846},{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.4182285964488983},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.41664621233940125},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.36435848474502563},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3529123067855835},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.32241642475128174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3030714988708496},{"id":"https://openalex.org/C9679016","wikidata":"https://www.wikidata.org/wiki/Q1417473","display_name":"Principle of maximum entropy","level":2,"score":0.2870662212371826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2586780786514282},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24448928236961365},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18895000219345093},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1674804389476776},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11975300312042236},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C5655090","wikidata":"https://www.wikidata.org/wiki/Q192588","display_name":"Relational database","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0218127405012636","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127405012636","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1506809288","https://openalex.org/W1582633447","https://openalex.org/W1746680969","https://openalex.org/W1968856189","https://openalex.org/W1976135752","https://openalex.org/W1978319180","https://openalex.org/W1989914718","https://openalex.org/W1990019150","https://openalex.org/W1995875735","https://openalex.org/W1995945562","https://openalex.org/W2030029305","https://openalex.org/W2035088664","https://openalex.org/W2040704490","https://openalex.org/W2082293106","https://openalex.org/W2085009317","https://openalex.org/W2094425445","https://openalex.org/W2097637456","https://openalex.org/W2114948431","https://openalex.org/W2118674424","https://openalex.org/W2130721915","https://openalex.org/W2905482938","https://openalex.org/W4247967931","https://openalex.org/W4302423442","https://openalex.org/W4388252848"],"related_works":["https://openalex.org/W1512401680","https://openalex.org/W2466816617","https://openalex.org/W73317730","https://openalex.org/W1970834875","https://openalex.org/W3174028392","https://openalex.org/W2116767780","https://openalex.org/W2000517284","https://openalex.org/W2349909726","https://openalex.org/W4313422465","https://openalex.org/W4367681419"],"abstract_inverted_index":{"Cell":[0],"differentiation":[1],"is":[2,54,79,103,130,133],"a":[3,15,45,51,70],"complex":[4],"process":[5],"governed":[6],"by":[7,135],"the":[8,58,85,115,118],"timely":[9],"activation":[10],"of":[11,60,72,114,124],"genes":[12,37],"resulting":[13],"in":[14,27,144],"specific":[16],"phenotype":[17],"or":[18],"observable":[19],"physical":[20],"change.":[21],"Recent":[22],"reports":[23],"have":[24],"indicated":[25],"heterogeneity":[26],"gene":[28],"expression":[29],"even":[30],"amongst":[31],"identical":[32],"colonies":[33,125],"(clones).":[34],"While":[35],"some":[36],"are":[38,42,93,142],"always":[39],"expressed,":[40],"others":[41],"expressed":[43],"with":[44],"finite":[46],"probability.":[47],"In":[48],"this":[49],"report,":[50],"mathematical":[52],"framework":[53],"provided":[55],"to":[56,81,105,121,150],"understand":[57],"mechanism":[59],"osteoblast":[61],"(bone":[62],"forming":[63],"cell)":[64],"differentiation.":[65],"A":[66],"systematic":[67],"approach":[68,78],"using":[69,95],"combination":[71],"entropy,":[73],"pair-wise":[74],"dependency":[75],"and":[76,87,98,117,128,146],"Bayesian":[77],"used":[80],"gain":[82],"insight":[83],"into":[84],"dependencies":[86,92,116],"underlying":[88],"network":[89,119],"structure.":[90],"Pairwise":[91],"estimated":[94],"linear":[96],"correlation":[97],"mutual":[99,109],"information.":[100],"An":[101],"algorithm":[102],"proposed":[104],"identify":[106],"statistically":[107],"significant":[108],"information":[110],"estimates.":[111],"The":[112,139],"robustness":[113],"structure":[120],"decreasing":[122],"number":[123],"(colony":[126],"size)":[127],"perturbation":[129],"investigated.":[131],"Perturbation":[132],"achieved":[134],"generating":[136],"bootstrap":[137],"samples.":[138],"methods":[140],"discussed":[141],"generic":[143],"nature":[145],"can":[147],"be":[148],"extended":[149],"similar":[151],"experimental":[152],"paradigms.":[153]},"counts_by_year":[{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
