{"id":"https://openalex.org/W2111191787","doi":"https://doi.org/10.1142/s0218127403008806","title":"ELECTRICAL ACTIVITY AND REENTRY DURING ACUTE REGIONAL MYOCARDIAL ISCHEMIA: INSIGHTS FROM SIMULATIONS","display_name":"ELECTRICAL ACTIVITY AND REENTRY DURING ACUTE REGIONAL MYOCARDIAL ISCHEMIA: INSIGHTS FROM SIMULATIONS","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2111191787","doi":"https://doi.org/10.1142/s0218127403008806","mag":"2111191787"},"language":"en","primary_location":{"id":"doi:10.1142/s0218127403008806","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127403008806","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070750789","display_name":"J.M. Ferrero","orcid":"https://orcid.org/0000-0003-4200-9225"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JOS\u00c9 M. FERRERO","raw_affiliation_strings":["Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s/n, 46020 Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s/n, 46020 Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070863677","display_name":"Beatriz Tr\u00e9nor","orcid":"https://orcid.org/0000-0001-9166-6112"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"BEATRIZ TR\u00c9NOR","raw_affiliation_strings":["Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s/n, 46020 Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s/n, 46020 Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067810825","display_name":"Blanca Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-6361-3339"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"BLANCA RODR\u00cdGUEZ","raw_affiliation_strings":["Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s/n, 46020 Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s/n, 46020 Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063676325","display_name":"Javier S\u00e1iz","orcid":"https://orcid.org/0000-0002-9850-0825"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JAVIER S\u00c1IZ","raw_affiliation_strings":["Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s/n, 46020 Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n e  Innovaci\u00f3n en Bioingenier\u00eda, Departamento de Ingenier\u00eda Electr\u00f3nica, Universidad Polit\u00e9cnica de Valencia, Camino de Vera s/n, 46020 Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2425,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.82812283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"12","first_page":"3703","last_page":"3715"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reentry","display_name":"Reentry","score":0.9721384048461914},{"id":"https://openalex.org/keywords/ischemia","display_name":"Ischemia","score":0.5763610601425171},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"Ventricular fibrillation","score":0.5700555443763733},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5104712247848511},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"Myocardial ischemia","score":0.4713137745857239},{"id":"https://openalex.org/keywords/ventricular-action-potential","display_name":"Ventricular action potential","score":0.4581003487110138},{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.4502333402633667},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4277368187904358},{"id":"https://openalex.org/keywords/fibrillation","display_name":"Fibrillation","score":0.4143986403942108},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3712655305862427},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.32960474491119385},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.22675871849060059},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.22639477252960205},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.106374591588974}],"concepts":[{"id":"https://openalex.org/C2777720157","wikidata":"https://www.wikidata.org/wiki/Q7306947","display_name":"Reentry","level":2,"score":0.9721384048461914},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5763610601425171},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.5700555443763733},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5104712247848511},{"id":"https://openalex.org/C3017461755","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Myocardial ischemia","level":3,"score":0.4713137745857239},{"id":"https://openalex.org/C47423411","wikidata":"https://www.wikidata.org/wiki/Q7920311","display_name":"Ventricular action potential","level":4,"score":0.4581003487110138},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.4502333402633667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4277368187904358},{"id":"https://openalex.org/C2777356233","wikidata":"https://www.wikidata.org/wiki/Q1001150","display_name":"Fibrillation","level":3,"score":0.4143986403942108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3712655305862427},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32960474491119385},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.22675871849060059},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.22639477252960205},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.106374591588974},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1142/s0218127403008806","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127403008806","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:b5dc66a1-0a06-4874-a8c6-87b57f53f064","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:b5dc66a1-0a06-4874-a8c6-87b57f53f064","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Computer Science","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323737","display_name":"Ministerio de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/034900433"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W140167789","https://openalex.org/W583020534","https://openalex.org/W1792544443","https://openalex.org/W1832821713","https://openalex.org/W1966638935","https://openalex.org/W1979884480","https://openalex.org/W1980350443","https://openalex.org/W1989157701","https://openalex.org/W2004492086","https://openalex.org/W2013137073","https://openalex.org/W2017549822","https://openalex.org/W2017792863","https://openalex.org/W2024954146","https://openalex.org/W2033923794","https://openalex.org/W2035823879","https://openalex.org/W2040212723","https://openalex.org/W2047794637","https://openalex.org/W2048591406","https://openalex.org/W2049229245","https://openalex.org/W2056367990","https://openalex.org/W2059306254","https://openalex.org/W2061285290","https://openalex.org/W2061352839","https://openalex.org/W2070434571","https://openalex.org/W2073521043","https://openalex.org/W2086276000","https://openalex.org/W2089620684","https://openalex.org/W2090696765","https://openalex.org/W2091235483","https://openalex.org/W2105870814","https://openalex.org/W2106649982","https://openalex.org/W2106904077","https://openalex.org/W2107130972","https://openalex.org/W2121217634","https://openalex.org/W2127318338","https://openalex.org/W2130680932","https://openalex.org/W2132561989","https://openalex.org/W2132603512","https://openalex.org/W2134561203","https://openalex.org/W2141571561","https://openalex.org/W2145459243","https://openalex.org/W2150990549","https://openalex.org/W2153027133","https://openalex.org/W2165006299","https://openalex.org/W2279919334","https://openalex.org/W2338532550"],"related_works":["https://openalex.org/W2058114572","https://openalex.org/W2112471274","https://openalex.org/W1522893685","https://openalex.org/W1734002048","https://openalex.org/W2102884991","https://openalex.org/W4239045977","https://openalex.org/W2028575086","https://openalex.org/W2133744831","https://openalex.org/W2128285589","https://openalex.org/W2471363944"],"abstract_inverted_index":{"In":[0],"this":[1,37],"work,":[2],"the":[3,11,43,48,63,85,99,118,126,133,150,160],"authors":[4],"use":[5],"computer":[6],"modeling":[7],"to":[8,29,135,156],"theoretically":[9],"investigate":[10],"mechanisms":[12,161],"involved":[13,162],"in":[14,132,143,163],"figure-of-eight":[15,108],"reentry":[16,119,136],"during":[17],"acute":[18,90],"regional":[19],"myocardial":[20],"ischemia,":[21],"a":[22,39,59,102],"pattern":[23],"of":[24,42,62,94,96,101,125,128,152],"excitation":[25,97],"which":[26,116],"may":[27],"lead":[28],"ventricular":[30],"fibrillation":[31],"and":[32,51,74,82,112,148,158],"sudden":[33],"cardiac":[34],"death.":[35],"For":[36],"purpose,":[38],"modified":[40],"version":[41],"Luo\u2013Rudy":[44],"dynamic":[45],"model":[46,61],"for":[47,79],"action":[49],"potential":[50],"ionic":[52,114],"currents":[53,115],"has":[54],"been":[55],"used,":[56],"together":[57],"with":[58,145],"two-dimensional":[60],"regionally":[64],"ischemic":[65,164],"ventricle.":[66],"The":[67,123,140],"virtual":[68],"tissue":[69],"comprises":[70],"several":[71],"realistically":[72],"dimensioned":[73],"located":[75],"transitional":[76],"border":[77],"zones":[78],"hyperkalemia,":[80],"hypoxia":[81],"acidosis,":[83],"simulating":[84],"substrate":[86],"heterogeneity":[87],"created":[88],"by":[89],"ischemia.":[91],"Different":[92],"types":[93],"patterns":[95],"following":[98],"delivery":[100],"premature":[103],"stimulus":[104],"were":[105],"obtained,":[106],"including":[107],"reentry.":[109,165],"Action":[110],"potentials":[111],"selected":[113],"explain":[117,159],"process":[120],"are":[121,142],"analyzed.":[122],"effect":[124],"degree":[127],"ATP-sensitive":[129],"current":[130],"activation":[131],"vulnerability":[134],"is":[137],"also":[138],"studied.":[139],"results":[141],"accordance":[144],"experimental":[146],"observations,":[147],"demonstrate":[149],"ability":[151],"second-generation":[153],"mathematical":[154],"models":[155],"analyze":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}