{"id":"https://openalex.org/W1996181924","doi":"https://doi.org/10.1142/s0218127403008776","title":"A SIMPLE MODEL FOR INTERACTION OF VOLTAGE AND CALCIUM DYNAMICS IN VIRTUAL VENTRICULAR TISSUE","display_name":"A SIMPLE MODEL FOR INTERACTION OF VOLTAGE AND CALCIUM DYNAMICS IN VIRTUAL VENTRICULAR TISSUE","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W1996181924","doi":"https://doi.org/10.1142/s0218127403008776","mag":"1996181924"},"language":"en","primary_location":{"id":"doi:10.1142/s0218127403008776","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127403008776","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084556958","display_name":"Oleg Aslanidi","orcid":"https://orcid.org/0000-0003-4813-7682"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I4210155801","display_name":"Institute of Cell Biophysics","ror":"https://ror.org/05gbnpz65","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210155801"]}],"countries":["GB","RU"],"is_corresponding":false,"raw_author_name":"O. V. ASLANIDI","raw_affiliation_strings":["Institute of Cell Biophysics, Pushchino,  142290, Russia","School of Biomedical Sciences, University of Leeds,  Leeds, LS2 9JT, UK","School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biophysics, Pushchino,  142290, Russia","institution_ids":["https://openalex.org/I4210155801"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Leeds,  Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028087836","display_name":"Arun V. Holden","orcid":"https://orcid.org/0000-0003-3731-2561"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. V. HOLDEN","raw_affiliation_strings":["School of Biomedical Sciences, University of Leeds,  Leeds, LS2 9JT, UK","School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, University of Leeds,  Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK,","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10103536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"12","first_page":"3873","last_page":"3886"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.7530039548873901},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.7338398694992065},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6248038411140442},{"id":"https://openalex.org/keywords/calcium-in-biology","display_name":"Calcium in biology","score":0.6145695447921753},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5315579771995544},{"id":"https://openalex.org/keywords/afterdepolarization","display_name":"Afterdepolarization","score":0.46384623646736145},{"id":"https://openalex.org/keywords/bursting","display_name":"Bursting","score":0.44585585594177246},{"id":"https://openalex.org/keywords/cell-membrane","display_name":"Cell membrane","score":0.4418303370475769},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.41426512598991394},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.3559836745262146},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.29539328813552856},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2710611820220947},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.21133431792259216},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.16988572478294373},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15260741114616394},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09520509839057922},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.09423485398292542},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.07447421550750732}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7530039548873901},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7338398694992065},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6248038411140442},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.6145695447921753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5315579771995544},{"id":"https://openalex.org/C155730078","wikidata":"https://www.wikidata.org/wiki/Q2898697","display_name":"Afterdepolarization","level":4,"score":0.46384623646736145},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.44585585594177246},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.4418303370475769},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.41426512598991394},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3559836745262146},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29539328813552856},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2710611820220947},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.21133431792259216},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16988572478294373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15260741114616394},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09520509839057922},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.09423485398292542},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.07447421550750732},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1142/s0218127403008776","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218127403008776","pdf_url":null,"source":{"id":"https://openalex.org/S81011612","display_name":"International Journal of Bifurcation and Chaos","issn_l":"0218-1274","issn":["0218-1274","1793-6551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bifurcation and Chaos","raw_type":"journal-article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/43834dbb-96de-4570-a6b3-4b8b3ab5e0b5","is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/43834dbb-96de-4570-a6b3-4b8b3ab5e0b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aslanidi, O & Holden, A V 2003, 'A simple model for interaction of voltage and calcium dynamics in virtual ventricular tissue', International Journal of Birfurcation and Chaos, vol. 13, no. 12, N/A, pp. 3873-3886. https://doi.org/10.1142/S0218127403008776","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1969014709","https://openalex.org/W1972135582","https://openalex.org/W1975522766","https://openalex.org/W1985940938","https://openalex.org/W1986783128","https://openalex.org/W1988107511","https://openalex.org/W1995058121","https://openalex.org/W1998890882","https://openalex.org/W2005865511","https://openalex.org/W2026032576","https://openalex.org/W2027813072","https://openalex.org/W2028467165","https://openalex.org/W2030295605","https://openalex.org/W2031053544","https://openalex.org/W2070993655","https://openalex.org/W2081547734","https://openalex.org/W2089089225","https://openalex.org/W2102074106","https://openalex.org/W2116945297","https://openalex.org/W2122714328","https://openalex.org/W2132561989","https://openalex.org/W2135771733","https://openalex.org/W2140477475","https://openalex.org/W2142180505","https://openalex.org/W2147528853","https://openalex.org/W2169084988","https://openalex.org/W2171159339","https://openalex.org/W2204633041"],"related_works":["https://openalex.org/W2029826786","https://openalex.org/W2392114838","https://openalex.org/W2057327025","https://openalex.org/W2070874188","https://openalex.org/W2088175708","https://openalex.org/W2378376661","https://openalex.org/W2350292833","https://openalex.org/W2056970011","https://openalex.org/W4250189773","https://openalex.org/W2007411156"],"abstract_inverted_index":{"A":[0],"simple":[1],"two-variable":[2],"model":[3],"is":[4,123],"used":[5],"to":[6,28,70,204],"replace":[7],"the":[8,14,38,44,52,59,85,94,100,106,118,126,143,151,160,186,189,199,212],"formulation":[9],"of":[10,58,117,142,153,166,170,177,198,206],"calcium":[11,65,81,121,130],"dynamics":[12,50],"in":[13,37,51,147,150],"Luo\u2013Rudy":[15],"ventricular":[16,20],"cell":[17,21,54,86,95,108],"model.":[18,40],"Virtual":[19],"and":[22,26,32,47,55,75,99],"tissue":[23,61,120],"are":[24,62],"developed":[25],"validated":[27],"reproduce":[29],"restitution":[30],"properties":[31],"calcium-dependent":[33],"voltage":[34,98],"patterns":[35,104],"present":[36],"original":[39,213],"Basic":[41],"interactions":[42],"between":[43],"membrane":[45],"potential":[46],"Ca":[48,102,180,201],"2+":[49,103,181,202],"virtual":[53,60,119],"a":[56,114,164,171,175],"strand":[57,116],"studied.":[63],"Intracellular":[64],"waves":[66],"can":[67,88,109,132,158],"be":[68,110,133],"linked":[69],"both":[71],"action":[72],"potentials":[73],"(APs)":[74],"delayed":[76],"afterdepolarizations":[77],"(DADs).":[78],"An":[79],"intracellular":[80,101,179,200],"wave":[82],"propagating":[83,149,156,172,214],"from":[84],"interior":[87],"induce":[89],"an":[90,207],"AP":[91,127,173],"upon":[92,135],"reaching":[93],"membrane.":[96],"The":[97],"within":[105],"same":[107],"highly":[111],"desynchronized.":[112],"In":[113],"one-dimensional":[115],"motion":[122],"driven":[124],"by":[125],"propagation.":[128],"However,":[129],"release":[131],"induced":[134],"certain":[136],"conditions":[137],"(e.g.":[138],"Na":[139,193],"+":[140,194],"overload":[141,195],"cells),":[144],"which":[145,210],"results":[146],"DADs":[148,157],"wake":[152],"AP.":[154,215],"Such":[155],"reach":[159],"excitation":[161],"threshold,":[162],"generating":[163],"pair":[165],"extrasystolic":[167,208],"APs.":[168],"Collision":[169],"with":[174],"site":[176],"elevated":[178],"concentration":[182],"does":[183],"not":[184],"affect":[185],"propagation":[187],"under":[188],"normal":[190],"conditions.":[191],"Under":[192],"local":[196],"elevation":[197],"leads":[203],"generation":[205],"AP,":[209],"destroys":[211]},"counts_by_year":[],"updated_date":"2026-08-14T07:06:38.338062","created_date":"2025-10-10T00:00:00"}