{"id":"https://openalex.org/W2119102216","doi":"https://doi.org/10.1142/s0218126609005745","title":"MINING PROTEIN REGULATORY RELATIONSHIPS USING NEURAL NETWORK METHODS FOR EARLY PREDICTION OF SARS","display_name":"MINING PROTEIN REGULATORY RELATIONSHIPS USING NEURAL NETWORK METHODS FOR EARLY PREDICTION OF SARS","publication_year":2009,"publication_date":"2009-11-30","ids":{"openalex":"https://openalex.org/W2119102216","doi":"https://doi.org/10.1142/s0218126609005745","mag":"2119102216"},"language":"en","primary_location":{"id":"doi:10.1142/s0218126609005745","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218126609005745","pdf_url":null,"source":{"id":"https://openalex.org/S167602672","display_name":"Journal of Circuits Systems and Computers","issn_l":"0218-1266","issn":["0218-1266","1793-6454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Circuits, Systems and Computers","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100757644","display_name":"Hongqiang Wang","orcid":"https://orcid.org/0000-0003-0610-8445"},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]},{"id":"https://openalex.org/I4210099079","display_name":"Institute of Intelligent Machines","ror":"https://ror.org/00w0qep84","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667","https://openalex.org/I4210099079"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"HONG-QIANG WANG","raw_affiliation_strings":["Intelligent Computing Lab, Hefei Institute of Intelligent Machines, Chinese Academy of Science, Hefei, China","Research Institute of Innovative Products and Technologies, The Hong Kong Polytechnic University, Hung Hom, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intelligent Computing Lab, Hefei Institute of Intelligent Machines, Chinese Academy of Science, Hefei, China","institution_ids":["https://openalex.org/I4210099079"]},{"raw_affiliation_string":"Research Institute of Innovative Products and Technologies, The Hong Kong Polytechnic University, Hung Hom, Hong Kong","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103540849","display_name":"Hai Long Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"HAI LONG ZHU","raw_affiliation_strings":["Research Institute of Innovative Products and Technologies, The Hong Kong Polytechnic University, Hung Hom, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Innovative Products and Technologies, The Hong Kong Polytechnic University, Hung Hom, Hong Kong","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064185915","display_name":"Chun-Hou Zheng","orcid":"https://orcid.org/0000-0002-2695-1926"},"institutions":[{"id":"https://openalex.org/I4210099079","display_name":"Institute of Intelligent Machines","ror":"https://ror.org/00w0qep84","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667","https://openalex.org/I4210099079"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHUNHOU ZHENG","raw_affiliation_strings":["Intelligent Computing Lab, Hefei Institute of Intelligent Machines, Chinese Academy of Science, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intelligent Computing Lab, Hefei Institute of Intelligent Machines, Chinese Academy of Science, Hefei, China","institution_ids":["https://openalex.org/I4210099079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109215748","display_name":"Timothy T. C. Yip","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166598","display_name":"Queen Elizabeth Hospital","ror":"https://ror.org/05ee2qy47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210166598"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"TIMOTHY T. C. YIP","raw_affiliation_strings":["Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong","institution_ids":["https://openalex.org/I4210166598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049313911","display_name":"William C. Cho","orcid":"https://orcid.org/0000-0003-4174-4586"},"institutions":[{"id":"https://openalex.org/I4210166598","display_name":"Queen Elizabeth Hospital","ror":"https://ror.org/05ee2qy47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210166598"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WILLIAM C. S. CHO","raw_affiliation_strings":["Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong","institution_ids":["https://openalex.org/I4210166598"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111970363","display_name":"Stephen C.K. Law","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166598","display_name":"Queen Elizabeth Hospital","ror":"https://ror.org/05ee2qy47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210166598"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"STEPHEN C. K. LAW","raw_affiliation_strings":["Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong","institution_ids":["https://openalex.org/I4210166598"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.16090329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"08","first_page":"1397","last_page":"1407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sigmoid-function","display_name":"Sigmoid function","score":0.8108286261558533},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.631976306438446},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.6295584440231323},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5247842669487},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5072988867759705},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5070886611938477},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.42945578694343567},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4235490560531616},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08325913548469543}],"concepts":[{"id":"https://openalex.org/C81388566","wikidata":"https://www.wikidata.org/wiki/Q526668","display_name":"Sigmoid function","level":3,"score":0.8108286261558533},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.631976306438446},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.6295584440231323},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5247842669487},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5072988867759705},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5070886611938477},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.42945578694343567},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4235490560531616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08325913548469543},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1142/s0218126609005745","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0218126609005745","pdf_url":null,"source":{"id":"https://openalex.org/S167602672","display_name":"Journal of Circuits Systems and Computers","issn_l":"0218-1266","issn":["0218-1266","1793-6454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Circuits, Systems and Computers","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.603.4981","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.603.4981","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.intelengine.cn/doc/2009-2010/MINING PROTEIN REGULATORY RELATIONSHIPS.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W580164068","https://openalex.org/W1601740268","https://openalex.org/W2039729161","https://openalex.org/W2055522016","https://openalex.org/W2103561630","https://openalex.org/W2107177647","https://openalex.org/W2108579152","https://openalex.org/W2112326288","https://openalex.org/W2129542667","https://openalex.org/W2130446255","https://openalex.org/W2148462634","https://openalex.org/W2151276622","https://openalex.org/W2159605359","https://openalex.org/W2170112109","https://openalex.org/W4302042276"],"related_works":["https://openalex.org/W4385957115","https://openalex.org/W2061372042","https://openalex.org/W3047779762","https://openalex.org/W1520030019","https://openalex.org/W2071654592","https://openalex.org/W3104477175","https://openalex.org/W2088157920","https://openalex.org/W4283785902","https://openalex.org/W4313324256","https://openalex.org/W3170224572"],"abstract_inverted_index":{"This":[0],"paper":[1],"proposes":[2],"to":[3,24],"model":[4],"protein":[5],"regulation":[6],"networks":[7],"associated":[8,87],"with":[9,88],"severe":[10],"acute":[11],"respiratory":[12],"syndrome":[13],"(SARS)":[14],"for":[15],"early":[16,93],"prediction":[17,94],"of":[18,53,60,66,95],"SARS.":[19,96],"In":[20],"the":[21,56,61,67,80],"approach,":[22],"specific":[23],"a":[25,28,34,43,51,73],"patient":[26],"group,":[27],"regulatory":[29,85],"network":[30,37,68],"is":[31,39,48,69],"simulated":[32],"using":[33],"fully-connected":[35],"neural":[36],"and":[38,58,90],"optimized":[40],"towards":[41],"minimizing":[42],"novel":[44],"energy":[45],"function":[46],"that":[47,79],"defined":[49],"as":[50],"measure":[52],"disagreement":[54],"between":[55],"input":[57],"output":[59],"network.":[62],"The":[63],"nonlinear":[64],"version":[65],"achieved":[70],"by":[71],"applying":[72],"sigmoid":[74],"function.":[75],"Experimental":[76],"results":[77],"show":[78],"proposed":[81],"approaches":[82],"can":[83],"capture":[84],"patterns":[86],"SARS":[89],"efficiently":[91],"implement":[92]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
